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Cat. No.: HY-172943

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PLK1/PRC1-IN-1

PLK1/PRC1-IN-1 (compound B4) is a PLK1/PRC1 protein complex formation inhibitor. PLK1/PRC1-IN-1 can be used in the study of non-small cell lung cancer (NSCLC) .

For research use only. We do not sell to patients.

CAS No.: 2991469-28-2
Formula: C₂₄H₂₂F₃N₃O₄S
Molecular Weight:505.51

Storage:

Please store the product under the recommended conditions in the Certificate of Analysis.

Data Sheet (265 KB)

PLK1/PRC1-IN-1 Chemical Structure

CAS No.: 2991469-28-2

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Biological Activity
- Description
- Cellular Effect
Chemical Information
Purity & Documentation
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Biological Activity

Description

PLK1/PRC1-IN-1 (compound B4) is a PLK1/PRC1 protein complex formation inhibitor. PLK1/PRC1-IN-1 can be used in the study of non-small cell lung cancer (NSCLC) ^[1].

All Polo-like Kinase (PLK) Isoforms :

Cellular Effect

Cell Line	Type	Value	Description	References
MCF7	IC₅₀	6.24 μM Compound: 4Bd	Anticancer activity against human MCF7 cells assessed as inhibition of cell growth incubated for 48 hrs by crystal violet staining based analysis Anticancer activity against human MCF7 cells assessed as inhibition of cell growth incubated for 48 hrs by crystal violet staining based analysis	[PMID: 38657480]
MGC-803	IC₅₀	5.95 μM Compound: 4Bd	Anticancer activity against human MGC-803 cells assessed as inhibition of cell growth incubated for 48 hrs by crystal violet staining based analysis Anticancer activity against human MGC-803 cells assessed as inhibition of cell growth incubated for 48 hrs by crystal violet staining based analysis	[PMID: 38657480]
NCI-H460	IC₅₀	8.28 μM Compound: 4Bd	Anticancer activity against human NCI-H460 cells assessed as inhibition of cell growth incubated for 48 hrs by crystal violet staining based analysis Anticancer activity against human NCI-H460 cells assessed as inhibition of cell growth incubated for 48 hrs by crystal violet staining based analysis	[PMID: 38657480]
SK-OV-3	IC₅₀	7.42 μM Compound: 4Bd	Anticancer activity against human SK-OV-3 cells assessed as inhibition of cell growth incubated for 48 hrs by crystal violet staining based analysis Anticancer activity against human SK-OV-3 cells assessed as inhibition of cell growth incubated for 48 hrs by crystal violet staining based analysis	[PMID: 38657480]
T-24	IC₅₀	2.57 μM Compound: 4Bd	Anticancer activity against human T24 cells assessed as inhibition of cell growth incubated for 48 hrs by crystal violet staining based analysis Anticancer activity against human T24 cells assessed as inhibition of cell growth incubated for 48 hrs by crystal violet staining based analysis	[PMID: 38657480]

Chemical Information

CAS No. 2991469-28-2
Molecular Weight 505.51
Formula C₂₄H₂₂F₃N₃O₄S
SMILES

CN(CCN1C(C2=CC=CC3=C(C=CC(C1=O)=C23)S(=O)(NCC4=CC=C(C=C4)C(F)(F)F)=O)=O)C
Shipping

Room temperature in continental US; may vary elsewhere.
Storage

Please store the product under the recommended conditions in the Certificate of Analysis.

Purity & Documentation

Select Batch:

Purity: 99.98%

Assay: 99.98%

ee.: 99.98%

Data Sheet (265 KB)
COA (2659 KB)
Elemental Analysis Report (2659 KB)
HNMR (2659 KB)
CNMR (2659 KB)
RP-HPLC (2659 KB)
NP-HPLC (2659 KB)
MS (2659 KB)
LCMS (2659 KB)
IR (2659 KB)
GC (2659 KB)
OR (2659 KB)
SDS-PAGE (2659 KB)
SEC-HPLC (2659 KB)
Other Report (2659 KB)
Handling Instructions (2659 KB)

References

[1]. Li P, et al. Pharmacological inhibition of PLK1/PRC1 triggers mitotic catastrophe and sensitizes lung cancers to chemotherapy. Cell Death Dis. 2025 May 12;16(1):374. [Content Brief]

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Help & FAQs

How should lyophilized recombinant proteins be reconstituted and stored?

1. Before opening the cap, centrifuge the vial at 13000 rpm for 20-30 seconds. This step will ensure that any lyophilized powder that may have adhered to the cap or walls is collected at the bottom of the vial, minimizing the risk of product loss.

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Biological Activity
- Description
Chemical Information
Purity & Documentation
References

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PLK1/PRC1-IN-1

All Polo-like Kinase (PLK) Isoforms

Biological Activity

Chemical Information

Purity & Documentation

References

Calculators

Help & FAQs

PLK1/PRC1-IN-1 Related Classifications

HY-172943 Related Classifications