PRDM16 Protein, Human
PRDM16 Protein, Human is the recombinant human-derived PRDM16, expressed by E. coli , with tag Free labeled tag. ,
- Species: Human
- Source: E. coli
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Storage:Stored at -80°C for 1 year from date of receipt. It is stable at -20°C for 3 months after opening. It is recommended to freeze aliquots at -80°C for extended storage. Avoid repeated freeze-thaw cycles.
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Biological Activity
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Technical Parameters
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Product Properties
- Documentation
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Biological Activity
Description
PRDM16 Protein, Human is the recombinant human-derived PRDM16, expressed by E. coli , with tag Free labeled tag. ,
Background
PRDM16 is a DNA-binding protein that functions as a transcriptional regulator. It exhibits histone methyltransferase activity and monomethylates histone H3 at Lys-9 (H3K9me1) in vitro (By similarity). PRDM16 likely catalyzes the monomethylation of free histone H3 in the cytoplasm, which is then transported to the nucleus and incorporated into nucleosomes, serving as a substrate for SUV39H methyltransferases to catalyze H3K9 trimethylation (By similarity). It is probably one of the primary histone methyltransferases, along with MECOM/PRDM3, directing cytoplasmic H3K9me1 methylation (By similarity). PRDM16 plays a key role in the differentiation of brown adipose tissue (BAT), which specializes in dissipating chemical energy as heat in response to cold or excess feeding, while white adipose tissue (WAT) stores excess energy and regulates systemic metabolism (By similarity). Together with CEBPB, it regulates the differentiation of myoblastic precursors into brown adipocytes (By similarity). Additionally, PRDM16 functions as a repressor of TGF-beta signaling.
Technical Parameters
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Species Human
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Source E. coli
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Tag Tag Free
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Accession
Q9HAZ2-1 (P79-Y451)
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Gene ID63976
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Protein Length
Partial
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Synonyms
PRDM16; MDS1/EVI1-Like Gene 1; PR/SET Domain 16; PR Domain 16; PFM13; MGC166915; MEL1; [Histone H3]-Lysine(9) N-Methyltransferase; Transcription Factor MEL1; PR-Domain Zinc Finger Protein 16; KIAA1675; PR Domain-Containing Protein 16; KMT8F; Alternative P
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AA Sequence
PIPADFELRESSIPGAGLGVWAKRKMEAGERLGPCVVVPRAAAKETDFGWEQILTDVEVSPQEGCITKISEDLGSEKFCVDANQAGAGSWLKYIRVACSCDDQNLTMCQISEQIYYKVIKDIEPGEELLVHVKEGVYPLGTVPPGLDEEPTFRCDECDELFQSKLDLRRHKKYTCGSVGAALYEGLAEELKPEGLGGGSGQAHECKDCERMFPNKYSLEQHMVIHTEEREYKCDQCPKAFNWKSNLIRHQMSHDSGKRFECENCVKVFTDPSNLQRHIRSQHVGARAHACPDCGKTFATSSGLKQHKHIHSTVKPFICEVCHKSYTQFSNLCRHKRMHADCRTQIKCKDCGQMFSTTSSLNKHRRFCEGKNHY
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Predicted Molecular Mass
42.4 kDa
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Purity
≥ 95%, as determined by reducing SDS-PAGE.
Product Properties
Solution.
<1 EU/μg, determined by LAL method.
Please use rapid thawing with running water to thaw the protein.
Stored at -80°C for 1 year from date of receipt. It is stable at -20°C for 3 months after opening. It is recommended to freeze aliquots at -80°C for extended storage. Avoid repeated freeze-thaw cycles.
Shipping with dry ice.
Documentation
Calculators
Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
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