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  4. RGM-C Protein, Mouse (HEK293, His)

RGM-C Protein, Mouse (HEK293, His)

Cat. No.: HY-P78029
Handling Instructions

RGM-C Protein, a BMP coreceptor, crucially regulates hepcidin (HAMP) expression, influencing iron homeostasis through enhanced BMP signaling. It forms a molecular network by interacting with BMP2, BMP4, BMP6, BMPR1B, and TMPRSS6, collectively mediating BMP-related signaling pathways and modulating iron regulatory processes. RGM-C Protein, Mouse (HEK293, His) is the recombinant mouse-derived RGM-C protein, expressed by HEK293, with C-His labeled tag. The total length of RGM-C Protein, Mouse (HEK293, His) is 361 a.a., with molecular weight of 55-60 kDa & 36-40 kDa & 20-25 kDa, respectively.

For research use only. We do not sell to patients.

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Description

RGM-C Protein, a BMP coreceptor, crucially regulates hepcidin (HAMP) expression, influencing iron homeostasis through enhanced BMP signaling. It forms a molecular network by interacting with BMP2, BMP4, BMP6, BMPR1B, and TMPRSS6, collectively mediating BMP-related signaling pathways and modulating iron regulatory processes. RGM-C Protein, Mouse (HEK293, His) is the recombinant mouse-derived RGM-C protein, expressed by HEK293, with C-His labeled tag. The total length of RGM-C Protein, Mouse (HEK293, His) is 361 a.a., with molecular weight of 55-60 kDa & 36-40 kDa & 20-25 kDa, respectively.
Background

RGM-C serves as a bone morphogenetic protein (BMP) coreceptor, playing a pivotal role in the regulation of hepcidin (HAMP) expression and influencing iron homeostasis by enhancing BMP signaling. It interacts with BMP2, BMP4, BMP6, BMPR1B, and TMPRSS6, establishing a network of molecular associations that collectively contribute to its role in mediating BMP-related signaling pathways and modulating iron regulatory processes.
Species

Mouse
Source

HEK293
Tag

C-His
Accession

Q7TQ32-1 (G33-A393)
Gene ID

69585  [NCBI]
Molecular Construction
N-term
RGM-C (G33-A393)
Accession # Q7TQ32-1
His
C-term
Synonyms
Hemojuvelin; Rgmc; DL-M; HFE2; HFE2AMGC23953; HJV; JH; RGMC; RGM-C
Molecular Weight

55-60 kDa&36-40 kDa&20-25 kDa
Purity

Greater than 95% as determined by Tris-Bis PAGE.
Endotoxin Level

<1 EU/μg, determined by LAL method.
Documentation
Handling Instructions (2659 KB)

RGM-C Protein, Mouse (HEK293, His) Related Classifications

Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

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The reconstitution calculator equation

Volume (to add to vial) = Mass (in vial) ÷ Desired Reconstitution Concentration

Volume (to add to vial) = Mass (in vial) ÷ Desired Reconstitution Concentration
= ÷

The dilution calculator equation

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

This equation is commonly abbreviated as: C1V1 = C2V2

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
× = ×
C1   V1   C2   V2

The specific activity calculator equation

Specific Activity (Unit/mg) = 106 ÷ Biological Activity (ED50)

Specific Activity (Unit/mg) = 106 ÷ Biological Activity (ED50)
Unit/mg = 106 ÷ ng/mL

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