SENP7 Protein, Human
SENP7, a versatile protease, positively regulates the cGAS-STING pathway by desumoylating CGAS, enhancing its DNA-binding and activation. Specific to SUMO2 and SUMO3, SENP7 proficiently deconjugates poly-SUMO2 and poly-SUMO3 chains, dynamically regulating protein sumoylation. While less efficient in processing full-length SUMO proteins, SENP7's role in modulating the cGAS-STING pathway highlights its importance in innate immune responses. SENP7 Protein, Human is the recombinant human-derived SENP7 protein, expressed by E. coli , with tag free.
- Species: Human
- Source: E. coli
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Biological Activity
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Product Properties
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Biological Activity
SENP7, a versatile protease, positively regulates the cGAS-STING pathway by desumoylating CGAS, enhancing its DNA-binding and activation. Specific to SUMO2 and SUMO3, SENP7 proficiently deconjugates poly-SUMO2 and poly-SUMO3 chains, dynamically regulating protein sumoylation. While less efficient in processing full-length SUMO proteins, SENP7's role in modulating the cGAS-STING pathway highlights its importance in innate immune responses. SENP7 Protein, Human is the recombinant human-derived SENP7 protein, expressed by E. coli , with tag free.
SENP7, a multifaceted protease, emerges as a positive regulator of the cGAS-STING pathway by facilitating the desumoylation of CGAS. This desumoylation process enhances the DNA-binding activity of CGAS, leading to its oligomerization and subsequent activation. SENP7 exhibits specificity in its desumoylation activity, targeting SUMO2 and SUMO3 but not SUMO1. Furthermore, the enzyme demonstrates proficiency in deconjugating poly-SUMO2 and poly-SUMO3 chains, contributing to the dynamic regulation of protein sumoylation. While SENP7 exhibits comparatively lower efficiency in processing full-length SUMO proteins to their mature forms, its role in modulating the cGAS-STING pathway underscores its significance in innate immune responses.
Technical Parameters
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Species Human
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Source E. coli
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Tag Tag Free
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Accession
Q9BQF6-1 (M695-A864)
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Molecular Construction
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N-term
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SENP7 (M695-A864)
Accession # Q9BQF6-1 -
C-term
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Protein Length
Partial
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Synonyms
SENP7; SUMO1/Sentrin Specific Peptidase 7; SUMO Specific Peptidase 7; SUMO1/Sentrin Specific Protease 7; Sentrin/SUMO-Specific Protease SENP7; KIAA1707; Sentrin-Specific Protease 7; SUSP2; SUMO-1-Specific Protease 2; SSP2
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AA Sequence
MKLKSVSQPSNTDAAKPTYTFLQKQSSGCYSLSITSNPDEEWREVRHTGLVQKLIVYPPPPTKGGLGVTNEDLECLEEGEFLNDVIIDFYLKYLILEKASDELVERSHIFSSFFYKCLTRKENNLTEDNPNLSMAQRRHKRVRTWTRHINIFNKDYIFVPVNESSHWYLA
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Predicted Molecular Mass
19.8 kDa
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Molecular Weight
Approximately 22 kDa, based on SDS-PAGE under reducing conditions.
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Purity
≥ 95%, as determined by reducing SDS-PAGE.
Documentation
Calculators
Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
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