Serpin F1 Protein, Mouse (375a.a)

Serpin F1 is a neurotrophin that significantly induces extensive neuronal differentiation of retinoblastoma cells and exhibits potent anti-angiogenic effects.Its unique conformation lacks the S (stress) to R (relaxation) transition typical of active serpins, resulting in a lack of serpin activity.Serpin F1 Protein, Mouse is the recombinant mouse-derived Serpin F1 protein, expressed by E.coli , with tag free.

Serpin F1, a neurotrophic protein, emerges as a key inducer of extensive neuronal differentiation in retinoblastoma cells. Notably, it exerts a potent inhibitory effect on angiogenesis. Distinguished by its unique conformational characteristics, Serpin F1 does not undergo the S (stressed) to R (relaxed) transition typical of active serpins, resulting in the absence of serine protease inhibitory activity. Furthermore, its interaction with PNPLA2 serves to stimulate the phospholipase A2 activity of PNPLA2, underscoring the multifaceted roles of Serpin F1 in cellular processes.

Measured by its ability to enhance the adhesion of Saos-2 human osteosarcoma cells to bovine Collagen I coated plate. The ED₅₀ for this effect is 0.4644 μg/mL, corresponding to a specific activity is 2.153×10³ units/mg.

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  Measured by its ability to enhance the adhesion of Saos-2 human osteosarcoma cells to bovine Collagen I coated plate. The ED₅₀ for this effect is 0.4644 μg/mL, corresponding to a specific activity is 2.153×10³ units/mg.

Mouse

E. coli

Tag Free

P97298 (D43-T417)

20317  [NCBI]

Partial

DPFFKVPVNKLAAAVSNFGYDLYRLRSSASPTGNVLLSPLSVATALSALSLGAEHRTESVIHRALYYDLITNPDIHSTYKELLASVTAPEKNLKSASRIVFERKLRVKSSFVAPLEKSYGTRPRILTGNPRVDLQEINNWVQAQMKGKIARSTREMPSALSILLLGVAYFKGQWVTKFDSRKTTLQDFHLDEDRTVRVPMMSDPKAILRYGLDSDLNCKIAQLPLTGSMSIIFFLPLTVTQNLTMIEESLTSEFIHDIDRELKTIQAVLTVPKLKLSFEGELTKSLQDMKLQSLFESPDFSKITGKPVKLTQVEHRAAFEWNEEGAGSSPSPGLQPVRLTFPLDYHLNQPFLFVLRDTDTGALLFIGRILDPSST

Approximately 40.0 kDa

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  ≥ 95%, as determined by reducing SDS-PAGE.

Solution.

Supplied as a 0.22 μm filtered solution of PBS, pH 7.4.

<1 EU/μg, determined by LAL method.

N/A.

Stored at -80°C for 1 year from date of receipt. It is stable at -20°C for 3 months after opening. It is recommended to freeze aliquots at -80°C for extended storage. Avoid repeated freeze-thaw cycles.

Shipping with dry ice.