SGTA Protein, Human (His)

SGTA proteins play a key role in promoting the release of oligosaccharides from the asparagine-linked glycoprotein peptide backbone by specifically targeting the GlcNAc-Asn bond. This enzymatic activity is essential for glycoprotein processing and maturation, contributing to post-translational modifications and protein quality control. SGTA Protein, Human (His) is the recombinant human-derived SGTA protein, expressed by E. coli , with N-6*His labeled tag. The total length of SGTA Protein, Human (His) is 313 a.a., with molecular weight of ~35.0 kDa.

AGA (Aspartylglucosaminidase) is a crucial enzyme that cleaves the GlcNAc-Asn bond, facilitating the release of oligosaccharides from the peptide backbone of asparagine-linked glycoproteins. This enzymatic activity is essential for the processing and maturation of glycoproteins, playing a key role in the intricate mechanisms of post-translational modification and protein quality control. By specifically targeting the GlcNAc-Asn linkage, AGA contributes to the generation of functionally mature glycoproteins, influencing various cellular processes. The precision of this cleavage highlights AGA's significance in maintaining the structural integrity and functionality of glycoproteins within the cellular milieu.

Human

E. coli

N-6*His

O43765 (M1-E313)

6449  [NCBI]

MDNKKRLAYAIIQFLHDQLRHGGLSSDAQESLEVAIQCLETAFGVTVEDSDLALPQTLPEIFEAAATGKEMPQDLRSPARTPPSEEDSAEAERLKTEGNEQMKVENFEAAVHFYGKAIELNPANAVYFCNRAAAYSKLGNYAGAVQDCERAICIDPAYSKAYGRMGLALSSLNKHVEAVAYYKKALELDPDNETYKSNLKIAELKLREAPSPTGGVGSFDIAGLLNNPGFMSMASNLMNNPQIQQLMSGMISGGNNPLGTPGTSPSQNDLASLIQAGQQFAQQMQQQNPELIEQLRSQIRSRTPSASNDDQQE

Approximately 35.0 kDa

Greater than 95% as determined by reducing SDS-PAGE.

<1 EU/μg, determined by LAL method.