SLC19A1 Protein, Human (HEK293, His-MBP, Flag)
The SLC19A1 protein acts as an antiporter, importing reduced folate and cyclic dinucleotides by exporting organic anions. It acts as a secondary active transporter, exporting intracellular organic anions to facilitate substrate uptake. SLC19A1 Protein, Human (HEK293, His-MBP, Flag) is the recombinant human-derived SLC19A1 protein, expressed by HEK293 , with N-8*His, C-Flag, N-MBP labeled tag.
- Species: Human
- Source: HEK293
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Storage:Stored at -80°C for 1 year from date of receipt. It is stable at -20°C for 3 months after opening. It is recommended to freeze aliquots at -80°C for extended storage. Avoid repeated freeze-thaw cycles.
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Biological Activity
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Technical Parameters
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Product Properties
- Documentation
- Help & FAQs
Biological Activity
The SLC19A1 protein acts as an antiporter, importing reduced folate and cyclic dinucleotides by exporting organic anions. It acts as a secondary active transporter, exporting intracellular organic anions to facilitate substrate uptake. SLC19A1 Protein, Human (HEK293, His-MBP, Flag) is the recombinant human-derived SLC19A1 protein, expressed by HEK293 , with N-8*His, C-Flag, N-MBP labeled tag.
The SLC19A1 protein operates as an antiporter, facilitating the import of reduced folates or a subset of cyclic dinucleotides through a mechanism driven by the export of organic anions. Functioning as a secondary active transporter, it exports intracellular organic anions down their concentration gradients to facilitate the uptake of its substrates. The protein exhibits high affinity for N5-methyltetrahydrofolate, the predominant circulating form of folate, and can mediate the import of the antifolate drug methotrexate. Additionally, it serves as an importer for immunoreactive cyclic dinucleotides, including cyclic GMP-AMP (2'-3'-cGAMP), an immune messenger produced in response to DNA viruses in the cytosol, and its linkage isomer 3'-3'-cGAMP, playing a role in triggering larger immune responses. Furthermore, the organic anion 5-amino-4-imidazolecarboxamide riboside (AICAR), when phosphorylated to AICAR monophosphate, serves as a substrate for the antiporter activity of SLC19A1.
Technical Parameters
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Species Human
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Source HEK293
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Tag N-8*His;C-Flag;N-MBP
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Accession
P41440 (V2-Q591)
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Gene ID6573
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Molecular Construction
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N-term
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8*His-MBP
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SLC19A1 (V2-Q591)
Accession # P41440 -
Flag
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C-term
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Protein Length
Partial
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Synonyms
SLC19A1; Cyclic Dinucleotide:Anion Antiporter SLC19A1; Solute Carrier Family 19 Member 1; Reduced Folate Carrier Protein; IFC-1; Placental Folate Transporter; RFT-1; Reduced Folate Carrier 1; FOLT; Folate Transporter 1; RFC1; HSLC19A1; HRFC; SLC19A1 Prote
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AA Sequence
VPSSPAVEKQVPVEPGPDPELRSWRHLVCYLCFYGFMAQIRPGESFITPYLLGPDKNFTREQVTNEITPVLSYSYLAVLVPVFLLTDYLRYTPVLLLQGLSFVSVWLLLLLGHSVAHMQLMELFYSVTMAARIAYSSYIFSLVRPARYQRVAGYSRAAVLLGVFTSSVLGQLLVTVGRVSFSTLNYISLAFLTFSVVLALFLKRPKRSLFFNRDDRGRCETSASELERMNPGPGGKLGHALRVACGDSVLARMLRELGDSLRRPQLRLWSLWWVFNSAGYYLVVYYVHILWNEVDPTTNSARVYNGAADAASTLLGAITSFAAGFVKIRWARWSKLLIAGVTATQAGLVFLLAHTRHPSSIWLCYAAFVLFRGSYQFLVPIATFQIASSLSKELCALVFGVNTFFATIVKTIITFIVSDVRGLGLPVRKQFQLYSVYFLILSIIYFLGAMLDGLRHCQRGHHPRQPPAQGLRSAAEEKAAQALSVQDKGLGGLQPAQSPPLSPEDSLGAVGPASLEQRQSDPYLAQAPAPQAAEFLSPVTTPSPCTLCSAQASGPEAADETCPQLAVHPPGVSKLGLQCLPSDGVQNVNQ
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Predicted Molecular Mass
108.6 kDa
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Purity
≥ 90%, as determined by reducing SDS-PAGE.
Product Properties
Solution.
<1 EU/μg, determined by LAL method.
Please use rapid thawing with running water to thaw the protein.
Stored at -80°C for 1 year from date of receipt. It is stable at -20°C for 3 months after opening. It is recommended to freeze aliquots at -80°C for extended storage. Avoid repeated freeze-thaw cycles.
Shipping with dry ice.
Documentation
Calculators
Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
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