SLC22A12 Protein, Human (HEK293)

SLC22A12 Protein, Human (HEK293) is the recombinant human-derived SLC22A12, expressed by HEK293 , with tag Free labeled tag. ,

SLC22A12 is an electroneutral antiporter that translocates urate across the apical membrane of proximal tubular cells in exchange for monovalent organic or inorganic anions. It is involved in the renal reabsorption of urate and helps maintain blood levels of uric acid. This protein mediates urate uptake by exchanging with organic anions such as (S)-lactate and nicotinate, as well as inorganic anion Cl(-). Other inorganic anions like Br(-), I(-), and NO3(-) may also act as counteranions for urate exchange. Additionally, SLC22A12 mediates orotate tubular uptake coupled with nicotinate efflux and, to a lesser extent, lactate efflux, suggesting a potential role in orotate renal reabsorption. Orotate transport is Cl(-)-dependent. by similar

Human

HEK293

Tag Free

Q96S37-1 (A2-F553) with several site mutations

116085

Partial

Approximately 60.7 kDa

≥ 85%, as determined by reducing SDS-PAGE.

Solution.

Supplied as a 0.22 μm filtered solution of 50 mM HEPES , pH 7.5, 150 mM NaCl, 0.003% (w/v) LMNG, 0.0003% (w/v) CHS.

<1 EU/μg, determined by LAL method.

Please use rapid thawing with running water to thaw the protein.

Stored at -80°C for 1 year from date of receipt. It is stable at -20°C for 3 months after opening. It is recommended to freeze aliquots at -80°C for extended storage. Avoid repeated freeze-thaw cycles.

Shipping with dry ice.