SLC2A9 Protein, Human (Cell-Free, His)

SLC2A9 Protein, validated by studies, serves as a high-capacity urate transporter in proximal tubules. Additionally, it exhibits residual glucose and fructose transporter activities. Its rapid urate transport (45- to 60-fold faster than glucose) underscores its pivotal role. Notably, it excludes galactose transport and modestly facilitates adenine uptake, contributing to diverse physiological processes. SLC2A9 Protein, Human (Cell-Free, His) is the recombinant human-derived SLC2A9 protein, expressed by E. coli Cell-free , with N-10*His labeled tag. The total length of SLC2A9 Protein, Human (Cell-Free, His) is 540 a.a., with molecular weight of 60.2 kDa.

SLC2A9 Protein emerges as a high-capacity urate transporter, showcasing its potential involvement in the reabsorption of urate by proximal tubules, as supported by several studies. This versatile transporter may also exhibit residual high-affinity, low-capacity glucose and fructose transporter activities, expanding its functional repertoire. Notably, SLC2A9 transports urate at rates significantly faster (45- to 60-fold) than glucose, underlining its prominence in urate transport processes. Interestingly, it does not transport galactose and may facilitate a modest uptake of adenine while remaining uninvolved in the transport of other nucleobases. This multifaceted transporter thus plays a crucial role in diverse physiological processes related to urate and potentially glucose and fructose transport.

Human

E. coli Cell-free

N-10*His

Q9NRM0 (M1-P540)

56606

MARKQNRNSKELGLVPLTDDTSHAGPPGPGRALLECDHLRSGVPGGRRRKDWSCSLLVASLAGAFGSSFLYGYNLSVVNAPTPYIKAFYNESWERRHGRPIDPDTLTLLWSVTVSIFAIGGLVGTLIVKMIGKVLGRKHTLLANNGFAISAALLMACSLQAGAFEMLIVGRFIMGIDGGVALSVLPMYLSEISPKEIRGSLGQVTAIFICIGVFTGQLLGLPELLGKESTWPYLFGVIVVPAVVQLLSLPFLPDSPRYLLLEKHNEARAVKAFQTFLGKADVSQEVEEVLAESRVQRSIRLVSVLELLRAPYVRWQVVTVIVTMACYQLCGLNAIWFYTNSIFGKAGIPPAKIPYVTLSTGGIETLAAVFSGLVIEHLGRRPLLIGGFGLMGLFFGTLTITLTLQDHAPWVPYLSIVGILAIIASFCSGPGGIPFILTGEFFQQSQRPAAFIIAGTVNWLSNFAVGLLFPFIQKSLDTYCFLVFATICITGAIYLYFVLPETKNRTYAEISQAFSKRNKAYPPEEKIDSAVTDGKINGRP

60.2 kDa

Greater than 90% as determined by reducing SDS-PAGE.

<1 EU/μg, determined by LAL method.