SLC35A2 Protein, Human (sf9, His, MBP, FLAG)
Based on 1 publication(s) in Google Scholar
SLC35A2 is a key transmembrane protein that acts as an antiporter to transport uridine diphosphate galactose (UDP-galactose) into the Golgi apparatus. The process involves the exchange of UDP-galactose with UMP and exhibits versatility through exchange with AMP and CMP. SLC35A2 Protein, Human (sf9, His, MBP, FLAG) is the recombinant human-derived SLC35A2 protein, expressed by sf9 insect cells , with N-MBP, C-Flag, N-8*His labeled tag.
- Species: Human
- Source: Sf9 insect cells
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Storage:Stored at -80°C for 1 year from date of receipt. It is stable at -20°C for 3 months after opening. It is recommended to freeze aliquots at -80°C for extended storage. Avoid repeated freeze-thaw cycles.
Biological Activity
Description
SLC35A2 is a key transmembrane protein that acts as an antiporter to transport uridine diphosphate galactose (UDP-galactose) into the Golgi apparatus. The process involves the exchange of UDP-galactose with UMP and exhibits versatility through exchange with AMP and CMP. SLC35A2 Protein, Human (sf9, His, MBP, FLAG) is the recombinant human-derived SLC35A2 protein, expressed by sf9 insect cells , with N-MBP, C-Flag, N-8*His labeled tag.
Background
SLC35A2, a pivotal transmembrane protein, operates as an antiporter facilitating the transportation of uridine diphosphate galactose (UDP-galactose) from the cytosol into the Golgi apparatus. This dynamic process involves the exchange of UDP-galactose for UMP and demonstrates versatility by also accommodating the exchange of UDP-galactose for AMP and CMP. Furthermore, SLC35A2 exhibits the ability to transport other nucleotide sugars, including UDP-N-acetylgalactosamine (UDP-GalNAc). Its role as a provider of UDP-galactose to galactosyltransferases within the Golgi apparatus is particularly crucial for the synthesis of globotriaosylceramide/globoside (Gb3Cer) from lactosylceramide, underscoring its significance in glycosphingolipid biosynthesis.
Publications (1)
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Journal Impact Factor
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Most Recent
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Biochem Pharmacol
The regulatory roles of pparα on hepatic drug-metabolizing enzymes in primary sclerosing cholangitis Syrian hamsters. [Abstract]2025 Sep 13;242(Pt 2):117339. PMID: 40953647
Technical Parameters
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Species Human
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Source Sf9 insect cells
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Tag N-MBP;C-Flag;N-8*His
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Accession
P78381 (A2-S396)
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Gene ID7355
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Molecular Construction
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N-term
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8*His-MBP
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SLC35A2 (A2-S396)
Accession # P78381 -
Flag
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C-term
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Protein Length
Full Length
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Synonyms
SLC35A2; UGT2; Prev. UGALT; Solute Carrier Family 35 (UDP-Galactose Transporter), Member 2; UDP-Gal-Tr; CDNA FLJ59970, Highly Similar To UDP-Galactose Translocator; UGTL; CDNA FLJ53300, Highly Similar To UDP-Galactose Translocator; UGT; UDP-Galactose Tran
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AA Sequence
AAVGAGGSTAAPGPGAVSAGALEPGTASAAHRRLKYISLAVLVVQNASLILSIRYARTLPGDRFFATTAVVMAEVLKGLTCLLLLFAQKRGNVKHLVLFLHEAVLVQYVDTLKLAVPSLIYTLQNNLQYVAISNLPAATFQVTYQLKILTTALFSVLMLNRSLSRLQWASLLLLFTGVAIVQAQQAGGGGPRPLDQNPGAGLAAVVASCLSSGFAGVYFEKILKGSSGSVWLRNLQLGLFGTALGLVGLWWAEGTAVATRGFFFGYTPAVWGVVLNQAFGGLLVAVVVKYADNILKGFATSLSIVLSTVASIRLFGFHVDPLFALGAGLVIGAVYLYSLPRGAAKAIASASASASGPCVHQQPPGQPPPPQLSSHRGDLITEPFLPKLLTKVKGS
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Purity
≥ 90%, as determined by reducing SDS-PAGE.
Product Properties
Solution.
<1 EU/μg, determined by LAL method.
Please use rapid thawing with running water to thaw the protein.
Stored at -80°C for 1 year from date of receipt. It is stable at -20°C for 3 months after opening. It is recommended to freeze aliquots at -80°C for extended storage. Avoid repeated freeze-thaw cycles.
Shipping with dry ice.
Documentation
Calculators
Concentration (start) × Volume (start) = Concentration (final) × Volume (final)