SLP-76 Protein, Human (His-T7)

The SLP-76 protein is critical in T cell antigen receptor-mediated signaling and participates in multiple molecular interactions. Its association with SLA coordinates T cell signaling, whereas its interaction with CBLB emphasizes regulatory effects. SLP-76 Protein, Human (His-T7) is the recombinant human-derived SLP-76 protein, expressed by E. coli , with N-T7, C-6*His labeled tag.

SLP-76 protein is a key player in T-cell antigen receptor-mediated signaling, intricately participating in various molecular interactions. Notably, it interacts with SLA, contributing to the orchestration of T-cell signaling events. Its association with CBLB emphasizes its involvement in regulatory processes. Additionally, SLP-76 engages in crucial interactions with signaling proteins, such as GRB2 and SHB, highlighting its role in signal transduction cascades. Moreover, SLP-76 forms complexes with PRAM1, contributing to the intricate network of protein interactions within T-cell signaling pathways. The binding between SLP-76 and CD6, particularly with the tyrosine-phosphorylated C-terminus of CD6, further underscores its significance in mediating cellular responses. Furthermore, SLP-76 interacts with FYB1 and the phosphorylated form of FYB2, adding another layer of complexity to its regulatory functions in T-cell signaling.

Human

E. coli

N-T7;C-6*His

Q13094 (M1-P533)

3937  [NCBI]

Full Length

MALRNVPFRSEVLGWDPDSLADYFKKLNYKDCEKAVKKYHIDGARFLNLTENDIQKFPKLRVPILSKLSQEINKNEERRSIFTRKPQVPRFPEETESHEEDNGGWSSFEEDDYESPNDDQDGEDDGDYESPNEEEEAPVEDDADYEPPPSNDEEALQNSILPAKPFPNSNSMYIDRPPSGKTPQQPPVPPQRPMAALPPPPAGRNHSPLPPPQTNHEEPSRSRNHKTAKLPAPSIDRSTKPPLDRSLAPFDREPFTLGKKPPFSDKPSIPAGRSLGEHLPKIQKPPLPPTTERHERSSPLPGKKPPVPKHGWGPDRRENDEDDVHQRPLPQPALLPMSSNTFPSRSTKPSPMNPLPSSHMPGAFSESNSSFPQSASLPPYFSQGPSNRPPIRAEGRNFPLPLPNKPRPPSPAEEENSLNEEWYVSYITRPEAEAALRKINQDGTFLVRDSSKKTTTNPYVLMVLYKDKVYNIQIRYQKESQVYLLGTGLRGKEDFLSVSDIIDYFRKMPLLLIDGKNRGSRYQCTLTHAAGYP

Approximately 70.0 kDa

• 
  ≥ 90%, as determined by reducing SDS-PAGE.

Solution.

Supplied as a 0.22 μm filtered solution of 20 mM Tris-HCl, 200 mM NaCl, 20% Glycerol, pH 8.5.
Note: For SPR assay, please replace the buffer. Primary amine components (e.g., Tris, imidazole) can affect protein-coupled chips.

<1 EU/μg, determined by LAL method.

N/A.

Stored at -80°C for 1 year from date of receipt. It is stable at -20°C for 3 months after opening. It is recommended to freeze aliquots at -80°C for extended storage. Avoid repeated freeze-thaw cycles.

Shipping with dry ice.