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SLP-76 Protein, Human (His-T7)

Cat. No.: HY-P71320
COA Handling Instructions

The SLP-76 protein is critical in T cell antigen receptor-mediated signaling and participates in multiple molecular interactions. Its association with SLA coordinates T cell signaling, whereas its interaction with CBLB emphasizes regulatory effects. SLP-76 Protein, Human (His-T7) is the recombinant human-derived SLP-76 protein, expressed by E. coli , with N-T7, C-6*His labeled tag. The total length of SLP-76 Protein, Human (His-T7) is 533 a.a., with molecular weight of ~70.0 kDa.

For research use only. We do not sell to patients.

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Description

The SLP-76 protein is critical in T cell antigen receptor-mediated signaling and participates in multiple molecular interactions. Its association with SLA coordinates T cell signaling, whereas its interaction with CBLB emphasizes regulatory effects. SLP-76 Protein, Human (His-T7) is the recombinant human-derived SLP-76 protein, expressed by E. coli , with N-T7, C-6*His labeled tag. The total length of SLP-76 Protein, Human (His-T7) is 533 a.a., with molecular weight of ~70.0 kDa.

Background

SLP-76 protein is a key player in T-cell antigen receptor-mediated signaling, intricately participating in various molecular interactions. Notably, it interacts with SLA, contributing to the orchestration of T-cell signaling events. Its association with CBLB emphasizes its involvement in regulatory processes. Additionally, SLP-76 engages in crucial interactions with signaling proteins, such as GRB2 and SHB, highlighting its role in signal transduction cascades. Moreover, SLP-76 forms complexes with PRAM1, contributing to the intricate network of protein interactions within T-cell signaling pathways. The binding between SLP-76 and CD6, particularly with the tyrosine-phosphorylated C-terminus of CD6, further underscores its significance in mediating cellular responses. Furthermore, SLP-76 interacts with FYB1 and the phosphorylated form of FYB2, adding another layer of complexity to its regulatory functions in T-cell signaling.

Species

Human

Source

E. coli

Tag

N-T7;C-6*His

Accession

Q13094 (M1-P533)

Gene ID
Molecular Construction
N-term
T7
SLP-76 (M1-P533)
Accession # Q13094
6*His
C-term
Synonyms
Lymphocyte cytosolic protein 2; SH2 domain-containing leukocyte protein of 76 kDa; SLP-76 tyrosine phosphoprotein; SLP76; LCP2
AA Sequence

MALRNVPFRSEVLGWDPDSLADYFKKLNYKDCEKAVKKYHIDGARFLNLTENDIQKFPKLRVPILSKLSQEINKNEERRSIFTRKPQVPRFPEETESHEEDNGGWSSFEEDDYESPNDDQDGEDDGDYESPNEEEEAPVEDDADYEPPPSNDEEALQNSILPAKPFPNSNSMYIDRPPSGKTPQQPPVPPQRPMAALPPPPAGRNHSPLPPPQTNHEEPSRSRNHKTAKLPAPSIDRSTKPPLDRSLAPFDREPFTLGKKPPFSDKPSIPAGRSLGEHLPKIQKPPLPPTTERHERSSPLPGKKPPVPKHGWGPDRRENDEDDVHQRPLPQPALLPMSSNTFPSRSTKPSPMNPLPSSHMPGAFSESNSSFPQSASLPPYFSQGPSNRPPIRAEGRNFPLPLPNKPRPPSPAEEENSLNEEWYVSYITRPEAEAALRKINQDGTFLVRDSSKKTTTNPYVLMVLYKDKVYNIQIRYQKESQVYLLGTGLRGKEDFLSVSDIIDYFRKMPLLLIDGKNRGSRYQCTLTHAAGYP

Molecular Weight

Approximately 70.0 kDa

Purity

Greater than 90% as determined by reducing SDS-PAGE.

Appearance

Solution.

Formulation

Supplied as a 0.2 μm filtered solution of 20 mM Tris-HCl, 200 mM NaCl, 20% Glycerol, pH 8.5.

Endotoxin Level

<1 EU/μg, determined by LAL method.

Storage & Stability

Stored at -80°C for 1 year. It is stable at -20°C for 3 months after opening. It is recommended to freeze aliquots at -80°C for extended storage. Avoid repeated freeze-thaw cycles.

Shipping

Shipping with dry ice.

Documentation

SLP-76 Protein, Human (His-T7) Related Classifications

Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

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The reconstitution calculator equation

Volume (to add to vial) = Mass (in vial) ÷ Desired Reconstitution Concentration

Volume (to add to vial) = Mass (in vial) ÷ Desired Reconstitution Concentration
= ÷

The dilution calculator equation

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

This equation is commonly abbreviated as: C1V1 = C2V2

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
× = ×
C1   V1   C2   V2

The specific activity calculator equation

Specific Activity (Unit/mg) = 106 ÷ Biological Activity (ED50)

Specific Activity (Unit/mg) = 106 ÷ Biological Activity (ED50)
Unit/mg = 106 ÷ ng/mL

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SLP-76 Protein, Human (His-T7)
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