SMG6 Protein, Human (His, Strep)
SMG6 Protein, Human (His, Strep) is the recombinant human-derived SMG6, expressed by E. coli , with Strep, His labeled tag. ,
- Species: Human
- Source: E. coli
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Storage:Stored at -80°C for 1 year from date of receipt. It is stable at -20°C for 3 months after opening. It is recommended to freeze aliquots at -80°C for extended storage. Avoid repeated freeze-thaw cycles.
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Biological Activity
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Technical Parameters
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Product Properties
- Documentation
- Help & FAQs
Biological Activity
Description
SMG6 Protein, Human (His, Strep) is the recombinant human-derived SMG6, expressed by E. coli , with Strep, His labeled tag. ,
Background
SMG6 is a component of the telomerase ribonucleoprotein (RNP) complex, essential for chromosome terminus replication. It may play a general role in telomere regulation and enhances TERT's ability to elongate telomeres in vitro. Overexpression induces telomere uncapping and chromosomal end-to-end fusions (with telomeric DNA persisting at fusion points) without disrupting TRF2 telomeric localization. SMG6 binds single-stranded 5'-(GTGTGG)(4)GTGT-3' telomeric DNA but not the telomerase RNA template component (TER). by similar: These functions were consistently observed across multiple studies.
Technical Parameters
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Species Human
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Source E. coli
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Tag Strep;His
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Accession
Q86US8-1 (E580-E1166)
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Gene ID23293
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Protein Length
Partial
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Synonyms
SMG6; Smg-6 Homolog, Nonsense Mediated MRNA Decay Factor (C. Elegans); Prev. C17orf31; Smg-6 Homolog, Nonsense Mediated MRNA Decay Factor; EST1A; SMG6, Nonsense Mediated MRNA Decay Factor; KIAA0732; Chromosome 17 Open Reading Frame 31; SMG-6; EST1 Telomer
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AA Sequence
ELHRLLRVADNQELQLSNLLSRDRISPEGLEKMAQLRAELLQLYERCILLDIEFSDNQNVDQILWKNAFYQVIEKFRQLVKDPNVENPEQIRNRLLELLDEGSDFFDSLLQKLQVTYKFKLEDYMDGLAIRSKPLRKTVKYALISAQRCMICQGDIARYREQASDTANYGKARSWYLKAQHIAPKNGRPYNQLALLAVYTRRKLDAVYYYMRSLAASNPILTAKESLMSLFEETKRKAEQMEKKQHEEFDLSPDQWRKGKKSTFRHVGDDTTRLEIWIHPSHPRSSQGTESGKDSEQENGLGSLSPSDLNKRFILSFLHAHGKLFTRIGMETFPAVAEKVLKEFQVLLQHSPSPIGSTRMLQLMTINMFAVHNSQLKDCFSEECRSVIQEQAAALGLAMFSLLVRRCTCLLKESAKAQLSSPEDQDDQDDIKVSSFVPDLKELLPSVKVWSDWMLGYPDTWNPPPTSLDLPSHVAVDVWSTLADFCNILTAVNQSEVPLYKDPDDDLTLLILEEDRLLSGFVPLLAAPQDPCYVEKTSDKVIAADCKRVTVLKYFLEALCGQEEPLLAFKGGKYVSVAPVPDTMGKE
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Predicted Molecular Mass
70.2 kDa
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Purity
≥ 90%, as determined by reducing SDS-PAGE.
Product Properties
Solution.
<1 EU/μg, determined by LAL method.
Please use rapid thawing with running water to thaw the protein.
Stored at -80°C for 1 year from date of receipt. It is stable at -20°C for 3 months after opening. It is recommended to freeze aliquots at -80°C for extended storage. Avoid repeated freeze-thaw cycles.
Shipping with dry ice.
Documentation
Calculators
Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
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