SRP54 Protein, Human (sf9, His)

SRP54, an essential component of the signal recognition particle (SRP) complex, contributes to the cotranslational targeting of secretory and membrane proteins to the endoplasmic reticulum (ER). Within the SRP complex, SRP54 associates with the SRP receptor (SR) component SRPRA to facilitate the targeting of secretory proteins to the ER membrane. Functioning at the forefront of this process, SRP54 binds to the signal sequence of presecretory proteins as they emerge from the ribosomes. Notably, SRP54 exhibits basal GTPase activity and collaborates in the reciprocal GTPase activation of the SR subunit SRPRA, forming a GTP-dependent complex crucial for SRP-mediated cotranslational protein translocation into the ER. The presence of SRP9/SRP14 and/or SRP19 is required for the stable interaction of SRP54 with RNA. Beyond its role in protein translocation, SRP54 plays a significant part in diverse cellular processes, including the regulation of granulocytic cell proliferation, neutrophil migration capacity, and the development of the exocrine pancreas.