TRPV2 Protein, Rat (Cell-Free, His)
The TRPV2 protein is a calcium-permeable nonselective cation channel with outward rectification and may be regulated by growth factors such as IGF1, PDGF, and morphogenetic neuropeptide/tau activator. TRPV2 Protein, Rat (Cell-Free, His) is the recombinant rat-derived TRPV2 protein, expressed by E. coli Cell-free, with N-10*His labeled tag.
- Species: Rat
- Source: E. coli Cell-free
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Storage:Stored at -20°C for 2 years from date of receipt. After reconstitution, it is stable at 4°C for 1 week or -20°C for longer (with carrier protein). It is recommended to freeze aliquots at -20°C or -80°C for extended storage.
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Biological Activity
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Technical Parameters
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Product Properties
- Documentation
- Help & FAQs
Biological Activity
Description
The TRPV2 protein is a calcium-permeable nonselective cation channel with outward rectification and may be regulated by growth factors such as IGF1, PDGF, and morphogenetic neuropeptide/tau activator. TRPV2 Protein, Rat (Cell-Free, His) is the recombinant rat-derived TRPV2 protein, expressed by E. coli Cell-free, with N-10*His labeled tag.
Background
TRPV2, a calcium-permeable, non-selective cation channel, exhibits outward rectification and is potentially regulated by growth factors such as IGF1, PDGF, and morphogenetic neuropeptide/head activator. This channel may play a role in transducing physical stimuli in mast cells. It is activated by temperatures exceeding 52 degrees Celsius but remains unresponsive to vanilloids and acidic pH. TRPV2 is likely organized as a homotetramer and interacts with a cAMP-dependent protein kinase type II regulatory subunit (PRKAR2A or PRKAR2B) and ACBD3. Additionally, TRPV2 engages in an interaction with SLC50A1, possibly within intracellular compartments, and this interaction is contingent on TRPV2 N-glycosylation. These molecular interactions suggest a multifaceted regulatory network governing TRPV2 function and responsiveness to various stimuli.
Technical Parameters
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Species Rat
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Source E. coli Cell-free
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Tag N-10*His
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Accession
Q9WUD2 (M1-P761)
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Gene ID29465
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Molecular Construction
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N-term
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10*His
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TRPV2 (M1-P761)
Accession # Q9WUD2 -
C-term
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Protein Length
Full Length
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Synonyms
Transient receptor potential cation channel subfamily V member 2; TrpV2; Osm-9-like TRP channel 2 (OTRPC2); Stretch-activated channel 2B; Vanilloid receptor-like protein 1 (VRL-1); Trpv2; Sac2b; Vrl1
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AA Sequence
MTSASSPPAFRLETSDGDEEGNAEVNKGKQEPPPMESPFQREDRNSSPQIKVNLNFIKRPPKNTSAPSQQEPDRFDRDRLFSVVSRGVPEELTGLLEYLRWNSKYLTDSAYTEGSTGKTCLMKAVLNLQDGVNACIMPLLQIDKDSGNPKLLVNAQCTDEFYQGHSALHIAIEKRSLQCVKLLVENGADVHLRACGRFFQKHQGTCFYFGELPLSLAACTKQWDVVTYLLENPHQPASLEATDSLGNTVLHALVMIADNSPENSALVIHMYDGLLQMGARLCPTVQLEEISNHQGLTPLKLAAKEGKIEIFRHILQREFSGPYQPLSRKFTEWCYGPVRVSLYDLSSVDSWEKNSVLEIIAFHCKSPNRHRMVVLEPLNKLLQEKWDRLVSRFFFNFACYLVYMFIFTVVAYHQPSLDQPAIPSSKATFGESMLLLGHILILLGGIYLLLGQLWYFWRRRLFIWISFMDSYFEILFLLQALLTVLSQVLRFMETEWYLPLLVLSLVLGWLNLLYYTRGFQHTGIYSVMIQKVILRDLLRFLLVYLVFLFGFAVALVSLSREARSPKAPEDNNSTVTEQPTVGQEEEPAPYRSILDASLELFKFTIGMGELAFQEQLRFRGVVLLLLLAYVLLTYVLLLNMLIALMSETVNHVADNSWSIWKLQKAISVLEMENGYWWCRRKKHREGRLLKVGTRGDGTPDERWCFRVEEVNWAAWEKTLPTLSEDPSGPGITGNKKNPTSKPGKNSASEEDHLPLQVLQSP
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Predicted Molecular Mass
88.2 kDa
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Purity
≥ 90%, as determined by reducing SDS-PAGE.
Product Properties
Lyophilized powder.
It is not recommended to reconstitute to a concentration less than 100 μg/mL in ddH2O. For long term storage it is recommended to add 5-50% of glycerol (final concentration). Our default final concentration of glycerol is 50%. Customers could use it as reference.
Stored at -20°C for 2 years from date of receipt. After reconstitution, it is stable at 4°C for 1 week or -20°C for longer (with carrier protein). It is recommended to freeze aliquots at -20°C or -80°C for extended storage.
Room temperature in continental US; may vary elsewhere.
Documentation
Calculators
Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
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