UBAC1 Protein, Human (GST)

UBAC1 protein, a non-catalytic component of the KPC complex, aids in polyubiquitination, targeting proteins like CDKN1B and NFKB1. The KPC complex regulates the cell cycle by ubiquitinating and degrading CDKN1B during the G1 phase. Additionally, it influences NF-kappa-B signaling by promoting NFKB1 maturation. Within the KPC complex, UBAC1 acts as an adapter, facilitating the transfer of polyubiquitinated proteins to the proteasome, emphasizing its role in protein ubiquitination processes. UBAC1 Protein, Human (GST) is the recombinant human-derived UBAC1 protein, expressed by E. coli, with N-GST labeled tag. The total length of UBAC1 Protein, Human (GST) is 405 a.a., with molecular weight of 72.3 kDa.

UBAC1 protein serves as a non-catalytic component within the KPC complex, an E3 ubiquitin-protein ligase complex responsible for mediating the polyubiquitination of target proteins, including CDKN1B and NFKB1. The KPC complex plays a crucial role in cell cycle regulation by catalyzing the polyubiquitination and subsequent proteasome-mediated degradation of CDKN1B during the G1 phase. Additionally, it serves as a key regulator of the NF-kappa-B signaling pathway by promoting the maturation of NFKB1 through ubiquitination of its p105 precursor. In the context of the KPC complex, UBAC1 functions as an adapter, facilitating the transfer of polyubiquitinated target proteins, courtesy of RNF123/KPC1, to the 26S proteasome. UBAC1's involvement underscores its contribution to protein modification processes, particularly in the realm of protein ubiquitination.

Human

E. coli

N-GST

Q9BSL1 (M1-T405)

10422  [NCBI]

MFVQEEKIFAGKVLRLHICASDGAEWLEEATEDTSVEKLKERCLKHCAHGSLEDPKSITHHKLIHAASERVLSDARTILEENIQDQDVLLLIKKRAPSPLPKMADVSAEEKKKQDQKAPDKEAILRATANLPSYNMDRAAVQTNMRDFQTELRKILVSLIEVAQKLLALNPDAVELFKKANAMLDEDEDERVDEAALRQLTEMGFPENRATKALQLNHMSVPQAMEWLIEHAEDPTIDTPLPGQAPPEAEGATAAASEAAAGASATDEEARDELTEIFKKIRRKREFRADARAVISLMEMGFDEKEVIDALRVNNNQQNAACEWLLGDRKPSPEELDKGIDPDSPLFQAILDNPVVQLGLTNPKTLLAFEDMLENPLNSTQWMNDPETGPVMLQISRIFQTLNRT

72.3 kDa

Greater than 90% as determined by reducing SDS-PAGE.

<1 EU/μg, determined by LAL method.