UBAC1 Protein, Human (GST)
Based on 1 publication(s) in Google Scholar
The UBAC1 protein is a non-catalytic component of the KPC complex and contributes to polyubiquitination, targeting proteins such as CDKN1B and NFKB1. The KPC complex regulates the cell cycle by ubiquitinating and degrading CDKN1B during G1 phase. UBAC1 Protein, Human (GST) is the recombinant human-derived UBAC1 protein, expressed by E. coli , with N-GST labeled tag.
- Species: Human
- Source: E. coli
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Storage:Stored at -20°C for 2 years from date of receipt. After reconstitution, it is stable at 4°C for 1 week or -20°C for longer (with carrier protein). It is recommended to freeze aliquots at -20°C or -80°C for extended storage.
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Biological Activity
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Technical Parameters
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Product Properties
- Documentation
- Help & FAQs
Biological Activity
Description
The UBAC1 protein is a non-catalytic component of the KPC complex and contributes to polyubiquitination, targeting proteins such as CDKN1B and NFKB1. The KPC complex regulates the cell cycle by ubiquitinating and degrading CDKN1B during G1 phase. UBAC1 Protein, Human (GST) is the recombinant human-derived UBAC1 protein, expressed by E. coli , with N-GST labeled tag.
Background
UBAC1 protein serves as a non-catalytic component within the KPC complex, an E3 ubiquitin-protein ligase complex responsible for mediating the polyubiquitination of target proteins, including CDKN1B and NFKB1. The KPC complex plays a crucial role in cell cycle regulation by catalyzing the polyubiquitination and subsequent proteasome-mediated degradation of CDKN1B during the G1 phase. Additionally, it serves as a key regulator of the NF-kappa-B signaling pathway by promoting the maturation of NFKB1 through ubiquitination of its p105 precursor. In the context of the KPC complex, UBAC1 functions as an adapter, facilitating the transfer of polyubiquitinated target proteins, courtesy of RNF123/KPC1, to the 26S proteasome. UBAC1's involvement underscores its contribution to protein modification processes, particularly in the realm of protein ubiquitination.
Publications (1)
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Journal Impact Factor
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Most Recent
Technical Parameters
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Species Human
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Source E. coli
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Tag N-GST
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Accession
Q9BSL1 (M1-T405)
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Molecular Construction
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N-term
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GST
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UBAC1 (M1-T405)
Accession # Q9BSL1 -
C-term
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Protein Length
Full Length
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Synonyms
UBAC1; UBA Domain Containing 1; UBADC1; GBDR1; KPC2; Ubiquitin-Associated Domain-Containing Protein 1; Kip1 Ubiquitination-Promoting Complex Protein 2; Glialblastoma Cell Differentiation-Related Protein 1; Kip1 Ubiquitination-Promoting Complex Subunit 2;
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AA Sequence
MFVQEEKIFAGKVLRLHICASDGAEWLEEATEDTSVEKLKERCLKHCAHGSLEDPKSITHHKLIHAASERVLSDARTILEENIQDQDVLLLIKKRAPSPLPKMADVSAEEKKKQDQKAPDKEAILRATANLPSYNMDRAAVQTNMRDFQTELRKILVSLIEVAQKLLALNPDAVELFKKANAMLDEDEDERVDEAALRQLTEMGFPENRATKALQLNHMSVPQAMEWLIEHAEDPTIDTPLPGQAPPEAEGATAAASEAAAGASATDEEARDELTEIFKKIRRKREFRADARAVISLMEMGFDEKEVIDALRVNNNQQNAACEWLLGDRKPSPEELDKGIDPDSPLFQAILDNPVVQLGLTNPKTLLAFEDMLENPLNSTQWMNDPETGPVMLQISRIFQTLNRT
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Predicted Molecular Mass
72.3 kDa
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Purity
≥ 90%, as determined by reducing SDS-PAGE.
Product Properties
Lyophilized powder.
<1 EU/μg, determined by LAL method.
It is not recommended to reconstitute to a concentration less than 100 μg/mL in ddH2O.
Stored at -20°C for 2 years from date of receipt. After reconstitution, it is stable at 4°C for 1 week or -20°C for longer (with carrier protein). It is recommended to freeze aliquots at -20°C or -80°C for extended storage.
Room temperature in continental US; may vary elsewhere.
Documentation
Calculators
Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
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