UPK2 Protein, Human (Cell-Free, His, SUMO)
UPK2 is a key component of the asymmetric unit membrane (AUM), a specialized biofilm made by terminally differentiated urothelial cells. Its presence suggests a potentially critical role in the complex regulation of AUM assembly. UPK2 Protein, Human (Cell-Free, His, SUMO) is the recombinant human-derived UPK2 protein, expressed by E. coli Cell-free , with N-6*His, N-SUMO labeled tag.
- Species: Human
- Source: E. coli Cell-free
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Storage:Stored at -20°C for 2 years from date of receipt. After reconstitution, it is stable at 4°C for 1 week or -20°C for longer (with carrier protein). It is recommended to freeze aliquots at -20°C or -80°C for extended storage.
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Biological Activity
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Technical Parameters
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Product Properties
- Documentation
- Help & FAQs
Biological Activity
Description
UPK2 is a key component of the asymmetric unit membrane (AUM), a specialized biofilm made by terminally differentiated urothelial cells. Its presence suggests a potentially critical role in the complex regulation of AUM assembly. UPK2 Protein, Human (Cell-Free, His, SUMO) is the recombinant human-derived UPK2 protein, expressed by E. coli Cell-free , with N-6*His, N-SUMO labeled tag.
Background
The UPK2 protein serves as a crucial constituent of the asymmetric unit membrane (AUM), a specialized biomembrane intricately developed by fully differentiated urothelial cells. Its potential involvement in regulating AUM assembly underscores its significance in maintaining the structural integrity and specialized functions of urothelial cells. Through its interaction with uroplakin-1a (UPK1A), UPK2 forms part of a molecular network that likely contributes to the unique properties of the AUM. This association highlights the intricate interplay between UPK2 and UPK1A, shedding light on their cooperative roles in the intricate biology of terminally differentiated urothelial cells (By similarity).
Technical Parameters
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Species Human
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Source E. coli Cell-free
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Tag N-6*His;N-SUMO
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Accession
O00526 (E85-K184)
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Gene ID7379
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Molecular Construction
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N-term
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6*His-SUMO
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UPK2 (E85-K184)
Accession # O00526 -
C-term
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Protein Length
Full Length of Mature Protein
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Synonyms
UPK2; Uroplakin 2; UPII; UP2; Uroplakin II; Uroplakin-2; MGC138598
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AA Sequence
ELVSVVDSGAGFTVTRLSAYQVTNLVPGTKFYISYLVKKGTATESSREIPMSTLPRRNMESIGLGMARTGGMVVITVLLSVAMFLLVLGFIIALALGSRK
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Predicted Molecular Mass
23.6 kDa
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Purity
≥ 90%, as determined by reducing SDS-PAGE.
Product Properties
Lyophilized powder.
<1 EU/μg, determined by LAL method.
It is not recommended to reconstitute to a concentration less than 100 μg/mL in ddH2O. For long term storage it is recommended to add 5-50% of glycerol (final concentration). Our default final concentration of glycerol is 50%. Customers could use it as reference.
Stored at -20°C for 2 years from date of receipt. After reconstitution, it is stable at 4°C for 1 week or -20°C for longer (with carrier protein). It is recommended to freeze aliquots at -20°C or -80°C for extended storage.
Room temperature in continental US; may vary elsewhere.
Documentation
Calculators
Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
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