Vps29 Protein, Human

The Vps29 protein is an important component of the reverse transcriptase cargo-selective complex (CSC), which prevents mispairing of transmembrane cargo proteins leading to lysosomal degradation. It coordinates retrograde transport from endosomes to the trans-Golgi network through distinct pathways involving the SNX-BAR, SNX3, and SNX27 retrosome complexes. Vps29 Protein, Human is the recombinant human-derived Vps29 protein, expressed by E. coli , with tag free. The total length of Vps29 Protein, Human is 182 a.a., .

Vps29 acts as a pivotal component of the retromer cargo-selective complex (CSC), playing a crucial role in preventing the missorting of selected transmembrane cargo proteins into the lysosomal degradation pathway. The CSC, acting as a recruitment hub, coordinates the retrograde transport of cargo proteins from endosomes to the trans-Golgi network (TGN) through distinct retromer pathways mediated by SNX-BAR, SNX3, and SNX27 retromer complexes. Vps29 is integral to the regulation of transcytosis, exemplified by its involvement in the retrieval and recycling of the polymeric immunoglobulin receptor (pIgR-pIgA). Additionally, Vps29 is a key component of the retriever complex, which functions independently of retromer in retrieving and recycling diverse cargos, including integrin alpha-5/beta-1 (ITGA5:ITGB1) and NxxY-motif-containing cargo proteins. The retriever complex's recruitment to endosomal membranes involves CCC and WASH complexes. Vps29 is implicated in GLUT1 endosome-to-plasma membrane trafficking, dependent on its association with ANKRD27. Notably, in the context of microbial infection, the retromer CSC mediates the exit of human papillomavirus from early endosomes and facilitates delivery to the Golgi apparatus.

Human

E. coli

Tag Free

Q9UBQ0 (M1-P182)

51699

Greater than 90% as determined by reducing SDS-PAGE.

<1 EU/μg, determined by LAL method.