(S)-Ponesimod

Cat. No.: HY-Z0676: Data Sheet Handling Instructions
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(S)-Ponesimod is a drug impurity.

For research use only. We do not sell to patients.

(S)-Ponesimod Chemical Structure

CAS No. : 854111-49-2

Size	Stock	Quantity
5 mg	In-stock	Estimated Time of Arrival: December 31
10 mg	In-stock	Estimated Time of Arrival: December 31
25 mg	In-stock	Estimated Time of Arrival: December 31
50 mg	In-stock	Estimated Time of Arrival: December 31
100 mg	In-stock	Estimated Time of Arrival: December 31
200 mg	Get quote
500 mg	Get quote

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Other Forms of (S)-Ponesimod:

(S)-Ponesimod (Standard) Get quote

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Description

(S)-Ponesimod is a drug impurity.

Cellular Effect

Cell Line	Type	Value	Description	References
CHO	EC₅₀	1108 nM Compound: 8bo, ACT-128800	Agonist activity at human recombinant S1P4 receptor expressed in CHO cells by GTPgammaS binding assay Agonist activity at human recombinant S1P4 receptor expressed in CHO cells by GTPgammaS binding assay	[PMID: 20446681]
CHO	EC₅₀	123 nM Compound: 8bo, ACT-128800	Agonist activity at human recombinant S1P3 receptor expressed in CHO cells by GTPgammaS binding assay Agonist activity at human recombinant S1P3 receptor expressed in CHO cells by GTPgammaS binding assay	[PMID: 20446681]
CHO	EC₅₀	59.1 nM Compound: 8bo, ACT-128800	Agonist activity at human recombinant S1P5 receptor expressed in CHO cells by GTPgammaS binding assay Agonist activity at human recombinant S1P5 receptor expressed in CHO cells by GTPgammaS binding assay	[PMID: 20446681]
CHO	EC₅₀	9.1 nM Compound: 8bo, ACT-128800	Agonist activity at human recombinant S1P1 receptor expressed in CHO cells by GTPgammaS binding assay Agonist activity at human recombinant S1P1 receptor expressed in CHO cells by GTPgammaS binding assay	[PMID: 20446681]
CHO	IC₅₀	142 nM Compound: 8bo, ACT-128800	Displacement of [33P]S1P from human recombinant S1P5 receptor expressed in CHO cells by scintillation counting Displacement of [33P]S1P from human recombinant S1P5 receptor expressed in CHO cells by scintillation counting	[PMID: 20446681]
CHO	IC₅₀	1956 nM Compound: 8bo, ACT-128800	Displacement of [33P]S1P from human recombinant S1P4 receptor expressed in CHO cells by scintillation counting Displacement of [33P]S1P from human recombinant S1P4 receptor expressed in CHO cells by scintillation counting	[PMID: 20446681]
HEK293	EC₅₀	105 nM Compound: 8bo, ACT-128800	Agonist activity at human recombinant S1P3 receptor expressed in HEK cells by GTPgammaS binding assay Agonist activity at human recombinant S1P3 receptor expressed in HEK cells by GTPgammaS binding assay	[PMID: 20446681]
HEK293	EC₅₀	5.7 nM Compound: 8bo, ACT-128800	Agonist activity at human recombinant S1P1 receptor expressed in HEK cells by GTPgammaS binding assay Agonist activity at human recombinant S1P1 receptor expressed in HEK cells by GTPgammaS binding assay	[PMID: 20446681]
HEK293	EC₅₀	> 10000 nM Compound: 8bo, ACT-128800	Agonist activity at human recombinant S1P2 receptor expressed in HEK cells by GTPgammaS binding assay Agonist activity at human recombinant S1P2 receptor expressed in HEK cells by GTPgammaS binding assay	[PMID: 20446681]
HEK293	IC₅₀	2068 nM Compound: 8bo, ACT-128800	Displacement of [33P]S1P from human recombinant S1P3 receptor expressed in HEK cells by scintillation counting Displacement of [33P]S1P from human recombinant S1P3 receptor expressed in HEK cells by scintillation counting	[PMID: 20446681]
HEK293	IC₅₀	6 nM Compound: 8bo, ACT-128800	Displacement of [33P]S1P from human recombinant S1P1 receptor expressed in HEK cells by scintillation counting Displacement of [33P]S1P from human recombinant S1P1 receptor expressed in HEK cells by scintillation counting	[PMID: 20446681]
HEK293	IC₅₀	> 10000 nM Compound: 8bo, ACT-128800	Displacement of [33P]S1P from human recombinant S1P2 receptor expressed in HEK cells by scintillation counting Displacement of [33P]S1P from human recombinant S1P2 receptor expressed in HEK cells by scintillation counting	[PMID: 20446681]

Molecular Weight

460.97

Formula

C₂₃H₂₅ClN₂O₄S

CAS No.

854111-49-2

Appearance

Solid

Color

Off-white to yellow

SMILES

O=C1N(C2=CC=CC=C2C)/C(S/C1=C\C3=CC=C(OC[C@@H](O)CO)C(Cl)=C3)=N/CCC

Shipping

Room temperature in continental US; may vary elsewhere.

Storage

Powder	-20°C	3 years
In solvent	-80°C	6 months
	-20°C	1 month

Purity & Documentation

Handling Instructions (2659 KB)

(S)-Ponesimod Related Classifications

Others

Molarity Calculator
Dilution Calculator

The molarity calculator equation

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

Mass		Concentration		Volume		Molecular Weight *
	=		×		×

The dilution calculator equation

Concentration _(start) × Volume _(start) = Concentration _(final) × Volume _(final)

This equation is commonly abbreviated as: C₁V₁ = C₂V₂

Concentration _(start)	×	Volume _(start)	=	Concentration _(final)	×	Volume _(final)
	×		=		×
C1		V1		C2		V2

Help & FAQs

Do most proteins show cross-species activity?
Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

(S)-Ponesimod854111-49-2Drug IntermediateDrug IintermediateInhibitorinhibitorinhibit

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(S)-Ponesimod

Other Forms of (S)-Ponesimod:

(S)-Ponesimod Related Antibodies

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•Related Small Molecules:

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Biological Activity

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Customer Review

(S)-Ponesimod Related Classifications

Molarity Calculator

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