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Cat. No.: HY-Z0676

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(S)-Ponesimod

Name: (S)-Ponesimod
Brand: MedChemExpress
SKU: HY-Z0676
Price: 50.00 USD
Availability: InStock
Rating: 5 (1 reviews)

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(S)-Ponesimod is a drug impurity.

For research use only. We do not sell to patients.

CAS No.: 854111-49-2
Formula: C₂₃H₂₅ClN₂O₄S
Molecular Weight:460.97

Storage:

Powder -20°C, 3 years ; In solvent -80°C, 6 months , -20°C, 1 month

Data Sheet (242 KB)

(S)-Ponesimod Chemical Structure

CAS No.: 854111-49-2

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Top Publications Citing

Use of MCE Products

Fluorescent Dye

Strong Fluorescence Signal / Multi-Disciplinary Applications / High Fluorescence Specificity

Biological Activity
- Description
- Cellular Effect
Chemical Information
Solvent & Solubility
- In Vitro
Purity & Documentation
Help & FAQs
Classifications
Bioz

Biological Activity

Description

(S)-Ponesimod is a drug impurity.

Cellular Effect

Cell Line	Type	Value	Description	References
CHO	EC₅₀	1108 nM Compound: 8bo, ACT-128800	Agonist activity at human recombinant S1P4 receptor expressed in CHO cells by GTPgammaS binding assay Agonist activity at human recombinant S1P4 receptor expressed in CHO cells by GTPgammaS binding assay	[PMID: 20446681]
CHO	EC₅₀	123 nM Compound: 8bo, ACT-128800	Agonist activity at human recombinant S1P3 receptor expressed in CHO cells by GTPgammaS binding assay Agonist activity at human recombinant S1P3 receptor expressed in CHO cells by GTPgammaS binding assay	[PMID: 20446681]
CHO	EC₅₀	59.1 nM Compound: 8bo, ACT-128800	Agonist activity at human recombinant S1P5 receptor expressed in CHO cells by GTPgammaS binding assay Agonist activity at human recombinant S1P5 receptor expressed in CHO cells by GTPgammaS binding assay	[PMID: 20446681]
CHO	EC₅₀	9.1 nM Compound: 8bo, ACT-128800	Agonist activity at human recombinant S1P1 receptor expressed in CHO cells by GTPgammaS binding assay Agonist activity at human recombinant S1P1 receptor expressed in CHO cells by GTPgammaS binding assay	[PMID: 20446681]
CHO	IC₅₀	142 nM Compound: 8bo, ACT-128800	Displacement of [33P]S1P from human recombinant S1P5 receptor expressed in CHO cells by scintillation counting Displacement of [33P]S1P from human recombinant S1P5 receptor expressed in CHO cells by scintillation counting	[PMID: 20446681]
CHO	IC₅₀	1956 nM Compound: 8bo, ACT-128800	Displacement of [33P]S1P from human recombinant S1P4 receptor expressed in CHO cells by scintillation counting Displacement of [33P]S1P from human recombinant S1P4 receptor expressed in CHO cells by scintillation counting	[PMID: 20446681]
HEK293	EC₅₀	>10000 nM Compound: 8bo, ACT-128800	Agonist activity at human recombinant S1P2 receptor expressed in HEK cells by GTPgammaS binding assay Agonist activity at human recombinant S1P2 receptor expressed in HEK cells by GTPgammaS binding assay	[PMID: 20446681]
HEK293	EC₅₀	105 nM Compound: 8bo, ACT-128800	Agonist activity at human recombinant S1P3 receptor expressed in HEK cells by GTPgammaS binding assay Agonist activity at human recombinant S1P3 receptor expressed in HEK cells by GTPgammaS binding assay	[PMID: 20446681]
HEK293	EC₅₀	5.7 nM Compound: 8bo, ACT-128800	Agonist activity at human recombinant S1P1 receptor expressed in HEK cells by GTPgammaS binding assay Agonist activity at human recombinant S1P1 receptor expressed in HEK cells by GTPgammaS binding assay	[PMID: 20446681]
HEK293	IC₅₀	>10000 nM Compound: 8bo, ACT-128800	Displacement of [33P]S1P from human recombinant S1P2 receptor expressed in HEK cells by scintillation counting Displacement of [33P]S1P from human recombinant S1P2 receptor expressed in HEK cells by scintillation counting	[PMID: 20446681]
HEK293	IC₅₀	2068 nM Compound: 8bo, ACT-128800	Displacement of [33P]S1P from human recombinant S1P3 receptor expressed in HEK cells by scintillation counting Displacement of [33P]S1P from human recombinant S1P3 receptor expressed in HEK cells by scintillation counting	[PMID: 20446681]
HEK293	IC₅₀	6 nM Compound: 8bo, ACT-128800	Displacement of [33P]S1P from human recombinant S1P1 receptor expressed in HEK cells by scintillation counting Displacement of [33P]S1P from human recombinant S1P1 receptor expressed in HEK cells by scintillation counting	[PMID: 20446681]

Chemical Information

CAS No. 854111-49-2
Appearance Solid
Molecular Weight 460.97
Formula C₂₃H₂₅ClN₂O₄S
Color Off-white to yellow
SMILES

O=C1N(C2=CC=CC=C2C)/C(S/C1=C\C3=CC=C(OC[C@@H](O)CO)C(Cl)=C3)=N/CCC
Shipping

Room temperature in continental US; may vary elsewhere.

Storage

Powder	-20°C	3 years
In solvent	-80°C	6 months
	-20°C	1 month

Solvent & Solubility

In Vitro:

DMSO : 100 mg/mL (216.93 mM; Need ultrasonic; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO)

View the Complete Stock Solution Preparation Table

Preparing Stock Solutions

View the Complete Stock Solution Preparation Table

Concentration Solvent Mass

1 mg

5 mg

10 mg

Concentration

Solvent

Mass

1 mM

2.1693 mL

10.8467 mL

21.6934 mL

5 mM

0.4339 mL

2.1693 mL

4.3387 mL

10 mM

0.2169 mL

1.0847 mL

2.1693 mL

Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.

Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

Molarity Calculator

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

Mass Mass

Concentration Concentration

Volume Volume

Molecular Weight Molecular Weight

Dilution Calculator

Concentration _(start) × Volume _(start) = Concentration _(final) × Volume _(final)

Concentration _(start) Concentration _(start)

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Purity & Documentation

Select Batch:

Purity: 99.98%

Assay: 99.98%

ee.: 99.98%

Data Sheet (242 KB)
COA (2659 KB)
Elemental Analysis Report (2659 KB)
HNMR (2659 KB)
CNMR (2659 KB)
RP-HPLC (2659 KB)
NP-HPLC (2659 KB)
MS (2659 KB)
LCMS (2659 KB)
IR (2659 KB)
GC (2659 KB)
OR (2659 KB)
SDS-PAGE (2659 KB)
SEC-HPLC (2659 KB)
Other Report (2659 KB)
Handling Instructions (2659 KB)

Help & FAQs

How should lyophilized recombinant proteins be reconstituted and stored?

1. Before opening the cap, centrifuge the vial at 13000 rpm for 20-30 seconds. This step will ensure that any lyophilized powder that may have adhered to the cap or walls is collected at the bottom of the vial, minimizing the risk of product loss.

Complete Stock Solution Preparation Table

Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

Optional Solvent	Concentration Solvent Mass	1 mg	5 mg	10 mg	25 mg
DMSO	1 mM	2.1693 mL	10.8467 mL	21.6934 mL	54.2335 mL
	5 mM	0.4339 mL	2.1693 mL	4.3387 mL	10.8467 mL
	10 mM	0.2169 mL	1.0847 mL	2.1693 mL	5.4233 mL
	15 mM	0.1446 mL	0.7231 mL	1.4462 mL	3.6156 mL
	20 mM	0.1085 mL	0.5423 mL	1.0847 mL	2.7117 mL
	25 mM	0.0868 mL	0.4339 mL	0.8677 mL	2.1693 mL
	30 mM	0.0723 mL	0.3616 mL	0.7231 mL	1.8078 mL
	40 mM	0.0542 mL	0.2712 mL	0.5423 mL	1.3558 mL
	50 mM	0.0434 mL	0.2169 mL	0.4339 mL	1.0847 mL
	60 mM	0.0362 mL	0.1808 mL	0.3616 mL	0.9039 mL
	80 mM	0.0271 mL	0.1356 mL	0.2712 mL	0.6779 mL
	100 mM	0.0217 mL	0.1085 mL	0.2169 mL	0.5423 mL

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MOQ

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100 mg

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Biological Activity
- Description
Chemical Information
Solvent & Solubility
- In Vitro
Purity & Documentation

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(S)-Ponesimod

Biological Activity

Description

Cellular Effect

Chemical Information

Solvent & Solubility

In Vitro:

Purity & Documentation

Help & FAQs

Complete Stock Solution Preparation Table

(S)-Ponesimod Related Classifications

HY-Z0676 Related Classifications

Bioz

Keywords

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