(S)-Ponesimod
Based on 1 Customer Validation
(S)-Ponesimod is a drug impurity.
For research use only. We do not sell to patients.
- CAS No.: 854111-49-2
- Formula: C23H25ClN2O4S
- Molecular Weight:460.97
-
Storage:Powder -20°C, 3 years ; In solvent -80°C, 6 months , -20°C, 1 month
Biological Activity
|
Cell Line
|
Type | Value | Description | References |
|---|---|---|---|---|
| CHO | EC50 |
1108 nM
Compound: 8bo, ACT-128800
|
Agonist activity at human recombinant S1P4 receptor expressed in CHO cells by GTPgammaS binding assay
Agonist activity at human recombinant S1P4 receptor expressed in CHO cells by GTPgammaS binding assay
|
[PMID: 20446681] |
| CHO | EC50 |
123 nM
Compound: 8bo, ACT-128800
|
Agonist activity at human recombinant S1P3 receptor expressed in CHO cells by GTPgammaS binding assay
Agonist activity at human recombinant S1P3 receptor expressed in CHO cells by GTPgammaS binding assay
|
[PMID: 20446681] |
| CHO | EC50 |
59.1 nM
Compound: 8bo, ACT-128800
|
Agonist activity at human recombinant S1P5 receptor expressed in CHO cells by GTPgammaS binding assay
Agonist activity at human recombinant S1P5 receptor expressed in CHO cells by GTPgammaS binding assay
|
[PMID: 20446681] |
| CHO | EC50 |
9.1 nM
Compound: 8bo, ACT-128800
|
Agonist activity at human recombinant S1P1 receptor expressed in CHO cells by GTPgammaS binding assay
Agonist activity at human recombinant S1P1 receptor expressed in CHO cells by GTPgammaS binding assay
|
[PMID: 20446681] |
| CHO | IC50 |
142 nM
Compound: 8bo, ACT-128800
|
Displacement of [33P]S1P from human recombinant S1P5 receptor expressed in CHO cells by scintillation counting
Displacement of [33P]S1P from human recombinant S1P5 receptor expressed in CHO cells by scintillation counting
|
[PMID: 20446681] |
| CHO | IC50 |
1956 nM
Compound: 8bo, ACT-128800
|
Displacement of [33P]S1P from human recombinant S1P4 receptor expressed in CHO cells by scintillation counting
Displacement of [33P]S1P from human recombinant S1P4 receptor expressed in CHO cells by scintillation counting
|
[PMID: 20446681] |
| HEK293 | EC50 |
>10000 nM
Compound: 8bo, ACT-128800
|
Agonist activity at human recombinant S1P2 receptor expressed in HEK cells by GTPgammaS binding assay
Agonist activity at human recombinant S1P2 receptor expressed in HEK cells by GTPgammaS binding assay
|
[PMID: 20446681] |
| HEK293 | EC50 |
105 nM
Compound: 8bo, ACT-128800
|
Agonist activity at human recombinant S1P3 receptor expressed in HEK cells by GTPgammaS binding assay
Agonist activity at human recombinant S1P3 receptor expressed in HEK cells by GTPgammaS binding assay
|
[PMID: 20446681] |
| HEK293 | EC50 |
5.7 nM
Compound: 8bo, ACT-128800
|
Agonist activity at human recombinant S1P1 receptor expressed in HEK cells by GTPgammaS binding assay
Agonist activity at human recombinant S1P1 receptor expressed in HEK cells by GTPgammaS binding assay
|
[PMID: 20446681] |
| HEK293 | IC50 |
>10000 nM
Compound: 8bo, ACT-128800
|
Displacement of [33P]S1P from human recombinant S1P2 receptor expressed in HEK cells by scintillation counting
Displacement of [33P]S1P from human recombinant S1P2 receptor expressed in HEK cells by scintillation counting
|
[PMID: 20446681] |
| HEK293 | IC50 |
2068 nM
Compound: 8bo, ACT-128800
|
Displacement of [33P]S1P from human recombinant S1P3 receptor expressed in HEK cells by scintillation counting
Displacement of [33P]S1P from human recombinant S1P3 receptor expressed in HEK cells by scintillation counting
|
[PMID: 20446681] |
| HEK293 | IC50 |
6 nM
Compound: 8bo, ACT-128800
|
Displacement of [33P]S1P from human recombinant S1P1 receptor expressed in HEK cells by scintillation counting
Displacement of [33P]S1P from human recombinant S1P1 receptor expressed in HEK cells by scintillation counting
|
[PMID: 20446681] |
Chemical Information
-
CAS No. 854111-49-2
-
Appearance Solid
-
Molecular Weight 460.97
-
Formula C23H25ClN2O4S
-
Color Off-white to yellow
-
SMILES
O=C1N(C2=CC=CC=C2C)/C(S/C1=C\C3=CC=C(OC[C@@H](O)CO)C(Cl)=C3)=N/CCC
-
Shipping
Room temperature in continental US; may vary elsewhere.
-
Storage
Powder -20°C 3 years In solvent -80°C 6 months -20°C 1 month
Purity & Documentation
Calculators
Concentration (start) × Volume (start) = Concentration (final) × Volume (final)