SARS-CoV-2 3CLpro-IN-39
SARS-CoV-2 3CLpro-IN-39 (compound 7c) is a broad-spectrum antiviral agent and 3CLpro inhibitor that inhibits SARS-CoV-2, HCoV-OC43, HCoV-HKU1 and HCoV-NL63 3CLpro with IC50 values of 20, 710, 22 and 470 nM, respectively. SARS-CoV-2 3CLpro-IN-39 functionally inhibits the 3CLpro enzymatic activity of different coronaviruses. SARS-CoV-2 3CLpro-IN-39 exhibits anti-SARS-CoV-2 and anti-HCoV-NL63 activities. SARS-CoV-2 3CLpro-IN-39 can be used in the research of coronavirus infections.
For research use only. We do not sell to patients.
- Formula: C26H26F3N3O4
- Molecular Weight:501.50
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Storage:
Please store the product under the recommended conditions in the Certificate of Analysis.
To place orders, for customer services and technical support, please contact: MedChemExpress USA
Tel: 609-228-6898 E-mail: [email protected] [email protected]
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Biological Activity
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Chemical Information
- Purity & Documentation
- References
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Help & FAQs
Biological Activity
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SARS-CoV-2 3CLpro 20 nM (IC50) |
HCoV-OC43 3CLpro 710 nM (IC50) |
HCoV-HKU1 3CLpro 22 nM (IC50) |
HCoV-NL63 3CLpro 470 nM (IC50) |
SARS-CoV-2 3CLpro-IN-39 (compound 7c) (5 min) potently inhibits 3CLpro of SARS-CoV-2, HCoV-OC43, HCoV-HKU1 and HCoV-NL63, with IC50 values of 20 nM, 710 nM, 22 nM and 470 nM, respectively. This compound exhibits comparable activity to Leritrelvir against β-coronavirus 3CLpro, and shows superior activity against 3CLpro of α-coronavirus HCoV-NL63[1].
SARS-CoV-2 3CLpro-IN-39 (pretreated for 1 h, incubated for 24 h/72 h) exhibits broad-spectrum antiviral activity against SARS-CoV-2 Omicron BA5 (EC50 = 410 nM in Vero E6 cells), HCoV-OC43 (EC50 = 110 nM in RD cells) and HCoV-NL63 (EC50 = 270 nM in LLC-MK2 cells). Its anti-SARS-CoV-2 activity is comparable to that of Leritrelvir (HY-153121), and its anti-HCoV-NL63 activity is superior. Moreover, it shows no cytotoxicity to RD cells at concentrations up to 200 μM[1].
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
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Cell Line:Vero E6 cells, RD cells, LLC-MK2 cells
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Concentration:serial dilutions
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Incubation Time:1 h (pre-treatment); 24 h (SARS-CoV-2, HCoV-OC43); 72 h (HCoV-NL63)
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Result:Exhibited anti-SARS-CoV-2 Omicron BA.5 activity with an EC50 of 410 nM, comparable to Leritrelvir (EC50 = 430 nM).
Exhibited anti-HCoV-OC43 activity with an EC50 of 110 nM.
Exhibited anti-HCoV-NL63 activity with an EC50 of 270 nM, more potent than Leritrelvir (EC50 = 380 nM).
Showed no cytotoxicity to RD cells at concentrations up to 200 μM (CC50 > 200 μM).
Chemical Information
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Molecular Weight 501.50
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Formula C26H26F3N3O4
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SMILES
O=C(N1C[C@H](C2=CC=CC=C2)C[C@H]1C(N[C@H](C=O)C[C@@H]3CCNC3=O)=O)C4=CC=CC(C(F)(F)F)=C4
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Shipping
Room temperature in continental US; may vary elsewhere.
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Storage
Please store the product under the recommended conditions in the Certificate of Analysis.
Purity & Documentation
References
Calculators
Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
SARS-CoV-2 3CLpro-IN-39 Related Classifications
HY-184687 Related Classifications
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