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Cat. No.: HY-170886

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SARS-CoV-2 Mpro-IN-36

SARS-CoV-2 Mpro-IN-36 (Compound 6d) is an inhibitor of SARS-CoV-2 M^pro with an IC₅₀ of 110 nM. SARS-CoV-2 Mpro-IN-36 exhibits antiviral activity with an EC₅₀ of 1.6 μM.

For research use only. We do not sell to patients.

Formula: C₂₅H₃₄FN₅O₇
Molecular Weight:535.57

Storage:

Please store the product under the recommended conditions in the Certificate of Analysis.

Data Sheet (274 KB)

SARS-CoV-2 Mpro-IN-36 Chemical Structure

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Use of MCE Products

Strong Fluorescence Signal / Multi-Disciplinary Applications / High Fluorescence Specificity

Biological Activity

Description

SARS-CoV-2 Mpro-IN-36 (Compound 6d) is an inhibitor of SARS-CoV-2 M^pro with an IC₅₀ of 110 nM. SARS-CoV-2 Mpro-IN-36 exhibits antiviral activity with an EC₅₀ of 1.6 μM^[1].

Chemical Information

Molecular Weight 535.57
Formula C₂₅H₃₄FN₅O₇
SMILES

O=C(OC(C)(C)C)NC1=CC(F)=CN([C@@H](CC2CC2)C(N[C@H](C(C(NC)=O)=O)C[C@H]3C(NCC3)=O)=O)C1=O
Shipping

Room temperature in continental US; may vary elsewhere.
Storage

Please store the product under the recommended conditions in the Certificate of Analysis.

Purity & Documentation

Select Batch:

Purity: 99.98%

Assay: 99.98%

ee.: 99.98%

Data Sheet (274 KB)
COA (2659 KB)
Elemental Analysis Report (2659 KB)
HNMR (2659 KB)
CNMR (2659 KB)
RP-HPLC (2659 KB)
NP-HPLC (2659 KB)
MS (2659 KB)
LCMS (2659 KB)
IR (2659 KB)
GC (2659 KB)
OR (2659 KB)
SDS-PAGE (2659 KB)
SEC-HPLC (2659 KB)
Other Report (2659 KB)
Handling Instructions (2659 KB)

References

[1]. Akula RK, et al. Structure-Based Optimization of Pyridone α-Ketoamides as Inhibitors of the SARS-CoV-2 Main Protease. J Med Chem. 2025 Feb 13;68(3):2920-2941. [Content Brief]

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Help & FAQs

How should lyophilized recombinant proteins be reconstituted and stored?

1. Before opening the cap, centrifuge the vial at 13000 rpm for 20-30 seconds. This step will ensure that any lyophilized powder that may have adhered to the cap or walls is collected at the bottom of the vial, minimizing the risk of product loss.

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100 mg

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