SARS-CoV-2 Mpro-IN-47
SARS-CoV-2 Mpro-IN-47 is an orally active SARS-CoV-2 Mpro reversible covalent Inhibitor. SARS-CoV-2 Mpro-IN-47 shows potent antiviral activity against several clinical variants of SARS-CoV-2. SARS-CoV-2 Mpro-IN-47 can be used for the research of infection, such as SARS-CoV-2.
For research use only. We do not sell to patients.
- Formula: C33H52N4O6
- Molecular Weight:600.79
-
Storage:
Please store the product under the recommended conditions in the Certificate of Analysis.
-
Biological Activity
-
Chemical Information
- Purity & Documentation
- References
-
Help & FAQs
Biological Activity
SARS-CoV-2 Mpro-IN-47 (Compound 18) shows inhibitory activities against SARS-CoV-2, 229E and MERS virus with IC50 values of 0.008, 0.01 and 0.11 μM[1].
SARS-CoV-2 Mpro-IN-47 shows antiviral activity against USA-WA1/2020, alpha, beta, delta, and omicron variants with EC50 ranging from 0.003 to 0.15μM[1].
SARS-CoV-2 Mpro-IN-47 does not inhibit (IC50 > 10 μM) host cell proteases, including various cysteine proteases, serine proteases, and aspartyl proteases[1].
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
| Species | Dose | Route | CL | F | Cmax | AUCinf | AUC | T1/2 |
|---|---|---|---|---|---|---|---|---|
| Dog[1] | 1 mg/kg | i.v. | 3.41 mL/min/kg | 16.0 % | / | / | / | / |
| Dog[1] | 5 mg/kg | p.o. | / | / | 2437 ng/mL | 6298 ng·h/mL | / | / |
| Mice[1] | 10 mg/kg | p.o. | 2.97 L/h/kg | 27 % | 1361.6 ng/mL | / | 917.5 ng·h/mL | / |
| Mice[1] | 5 mg/kg | i.v. | / | / | / | / | / | 0.87 h |
| Rat[1] | 10 mg/kg | p.o. | 0.81 L/h/kg | >100 % | 5189.48 ng/mL | / | 14375.6 ng·h/mL | / |
| Rat[1] | 5 mg/kg | i.v. | / | / | / | / | / | 2.87 h |
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
-
Animal Model:SARS-CoV-2-infected mice models[1]
-
Dosage:75 150 and 300 mg/kg
-
Administration:Orally administration, twice a day for 4 days
-
Result:Dose-dependently reduced lung virus titers.
Reduced the lung weights.
Chemical Information
-
Molecular Weight 600.79
-
Formula C33H52N4O6
-
SMILES
O=C(N[C@H](C(C(NC1CC1)=O)=O)C[C@H]2C(NCCC2)=O)[C@H](CC3CCC3)C(C)C([C@@H](C4CCCC4)NC(C(C)(C)C)=O)=O
-
Shipping
Room temperature in continental US; may vary elsewhere.
-
Storage
Please store the product under the recommended conditions in the Certificate of Analysis.
Purity & Documentation
References
Calculators
Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
Powered by Bioz