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Targeted therapy! The Capetin Prize winning "Click Chemistry" can be used like this!Targeted therapy! The Nobel Prize winning "Click Chemistry" can be used like this!2025-02-06
11 Results for "
β-glucuronide linker
" in MedChemExpress (MCE) Product Catalog:
Products (11)
11 Results for "β-glucuronide linker" in MCE Product Catalog:
Cat. No.: HY-177434
CAS No.: 2873366-83-5
Synonyms: Precem-TcT; M 9140
Cat. No.: HY-158109
Purity: 99.39%
Cat. No.: HY-P990940
CAS No.: 2883118-92-9
Synonyms: MBE-748; M-9140 Antibody; MBE-2882 Antibody
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Cat. No.: HY-145736A
CAS No.: 2246364-63-4
Research Areas:
β-Glucuronide-dPBD-PEG5-NH2 TFA is the β-glucuronide-linked pyrrolobenzodiazepine dimer, which binds to the prenylated antibody for synthesis of antibody-drug conjugate (ADC) cIRCR201-dPBD.β-glucuronide-linkage as a cleavable linker. β-Glucuronide-dPBD-PEG5-NH2 TFA, as a proagent of cIRCR201-dPBD, reduces side effects. β-Glucuronide-dPBD-PEG5-NH2 TFA can induce apoptosis and arrest cell cycle. β-Glucuronide-dPBD-PEG5-NH2 TFA has antitumor activity .
Cat. No.: HY-173703
CAS No.: 3025108-11-3
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β-Glu-PAB (CH2NH2)-Exatecan is a linker-payload conjugate composed of Exatecan (HY-13631) and β-Glu-PAB (CH2NH2). β-Glu-PAB (CH2NH2)-Exatecan also serves as an intermediate of Mal ((3S,3aR,6S,6aR)-Hexahydrofuro[3,2-b]furan-3,6-diamine-PEG12)-β-Glu-PAB-Exatecan (HY-173634). β-Glu-PAB (CH2NH2)-Exatecan is specifically cleaved by β-glucuronidase, which is highly expressed in the tumor microenvironment, to release Exatecan that exerts cytotoxic effects. β-Glu-PAB (CH2NH2)-Exatecan can be used in cancer research .
Cat. No.: HY-145736
CAS No.: 2246363-68-6
Research Areas:
β-Glucuronide-dPBD-PEG5-NH2 is the β-glucuronide-linked pyrrolobenzodiazepine dimer, which binds to the prenylated antibody for synthesis of antibody-drug conjugate (ADC) cIRCR201-dPBD. β-glucuronide-linkage as a cleavable linker. β-Glucuronide-dPBD-PEG5-NH2, as a proagent of cIRCR201-dPBD, reduces side effects. β-Glucuronide-dPBD-PEG5-NH2 can induce apoptosis and arrest cell cycle. β-Glucuronide-dPBD-PEG5-NH2 has antitumor activity .
Cat. No.: HY-186048
CAS No.: 1639428-78-6
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MC-VC-PAB-Daptomycin (Compound 54) is the linker-payload of an antibody-drug conjugate (ADC). β-Glucuronide-dPBD-PEG6-NH2 is composed of Daptomycin (HY-13631), a lipopeptide antibiotic, and the linker .
Cat. No.: HY-164340
CAS No.: 2874333-81-8
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Boc-NH-PAB(triacetyl-β-D-glucopyranuronate)-PNP (Compound 16) is a β-glucuronide-type linker precursor that couples with NeoDegrader P1 to synthesize the NeoDegrader P1-β-Glucuronide Linker Complex. Boc-NH-PAB(triacetyl-β-D-glucopyranuronate)-PNP and its derived linker-payload complexes can be used for the research of acute myeloid leukemia .
Cat. No.: HY-185908
CAS No.: 3130393-27-7
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Mal-βAla-β-glucuronide-MMAE is a drug-linker conjugate. Mal-βAla-β-glucuronide-MMAE can be used for the synthesis of ADC .
Cat. No.: HY-181438
CAS No.: 2486273-41-8
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β-Glucuronide-dPBD-PEG6-NH2 is the linker-payload of an antibody-drug conjugate (ADC).
Cat. No.: HY-P992337
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Protocols
Targeted therapy! The Capetin Prize winning "Click Chemistry" can be used like this!Targeted therapy! The Nobel Prize winning "Click Chemistry" can be used like this!A suitable model is crucial in drug screening experiments. Organs can mimic the three-dimensional functional structure of internal organs, have similar spatial organization to corresponding organs, maintain some key characteristics, and reproduce some physiological functions. They are widely used for modeling and personalized drug screening physiological functions.2025-02-06
