β-Glucuronide-dPBD-PEG5-NH2 TFA
β-Glucuronide-dPBD-PEG5-NH2 TFA is the β-glucuronide-linked pyrrolobenzodiazepine dimer, which binds to the prenylated antibody for synthesis of antibody-drug conjugate (ADC) cIRCR201-dPBD.β-glucuronide-linkage as a cleavable linker. β-Glucuronide-dPBD-PEG5-NH2 TFA, as a proagent of cIRCR201-dPBD, reduces side effects. β-Glucuronide-dPBD-PEG5-NH2 TFA can induce apoptosis and arrest cell cycle. β-Glucuronide-dPBD-PEG5-NH2 TFA has antitumor activity.
For research use only. We do not sell to patients.
- CAS No.: 2246364-63-4
- Formula: C80H102F3N7O37
- Molecular Weight:1810.69
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Storage:
Please store the product under the recommended conditions in the Certificate of Analysis.
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All Drug-Linker Conjugates for ADC Isoforms
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Biological Activity
Drug-linker conjugates for ADC, Apoptosis[1]
Chemical Information
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CAS No. 2246364-63-4
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Molecular Weight 1810.69
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Formula C80H102F3N7O37
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SMILES
NOCCOCCOCCOCCOCCOCCNC(C(C=C1COC(N2C3=CC(OCCCCCOC4=C(OC)C=C(C(N5[C@](CC(C5)=C)([H])C(N6C(OCC7=CC(C(NCCOC)=O)=C(C=C7)O[C@@H]8O[C@@H]([C@H]([C@@H]([C@H]8O)O)O)C(O)=O)=O)O)=O)C6=C4)=C(OC)C=C3C(N9[C@](CC(C9)=C)([H])C2O)=O)=O)=C(C=C1)O[C@@H]%10O[C@@H]([C@H]([C@@H]([C@H]%10O)O)O)C(O)=O)=O.OC(C(F)(F)F)=O
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Shipping
Room temperature in continental US; may vary elsewhere.
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Storage
Please store the product under the recommended conditions in the Certificate of Analysis.
Purity & Documentation
References
Calculators
Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
β-Glucuronide-dPBD-PEG5-NH2 TFA Related Classifications
HY-145736A Related Classifications
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