2246364-63-4
Chemical Structure
β-Glucuronide-dPBD-PEG5-NH2 TFA
- CAS No.: 2246364-63-4
- Formula:C80H102F3N7O37
- Molecular Weight:1810.69
IUPAC Name: (2S,3S,4S,5R,6S)-6-(2-((17-(aminooxy)-3,6,9,12,15-pentaoxaheptadecyl)carbamoyl)-4-((((11aS)-8-((5-(((11aS)-10-(((4-(((2S,3R,4S,5S,6S)-6-carboxy-3,4,5-trihydroxytetrahydro-2H-pyran-2-yl)oxy)-3-((2-methoxyethyl)carbamoyl)benzyl)oxy)carbonyl)-11-hydroxy-7-me
InChIKey: JYLFUHOIJHONJR-ABHUQNIYSA-N
SMILES: NOCCOCCOCCOCCOCCOCCNC(C(C=C1COC(N2C3=CC(OCCCCCOC4=C(OC)C=C(C(N5[C@](CC(C5)=C)([H])C(N6C(OCC7=CC(C(NCCOC)=O)=C(C=C7)O[C@@H]8O[C@@H]([C@H]([C@@H]([C@H]8O)O)O)C(O)=O)=O)O)=O)C6=C4)=C(OC)C=C3C(N9[C@](CC(C9)=C)([H])C2O)=O)=O)=C(C=C1)O[C@@H]%10O[C@@H]([C@H]([C@@H]([C@H]%10O)O)O)C(O)=O)=O.OC(C(F)(F)F)=O
Biological Activity: β-Glucuronide-dPBD-PEG5-NH2 TFA is the β-glucuronide-linked pyrrolobenzodiazepine dimer, which binds to the prenylated antibody for synthesis of antibody-drug conjugate (ADC) cIRCR201-dPBD.β-glucuronide-linkage as a cleavable linker. β-Glucuronide-dPBD-PEG5-NH2 TFA, as a proagent of cIRCR201-dPBD, reduces side effects. β-Glucuronide-dPBD-PEG5-NH2 TFA can induce apoptosis and arrest cell cycle. β-Glucuronide-dPBD-PEG5-NH2 TFA has antitumor activity[1].
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β-Glucuronide-dPBD-PEG5-NH2 TFA | β-Glucuronide-dPBD-PEG5-NH2 TFA is the β-glucuronide-linked pyrrolobenzodiazepine dimer, which binds to the prenylated antibody for synthesis of antibody-drug conjugate (ADC) cIRCR201-dPBD.β-glucuronide-linkage as a cleavable linker. β-Glucuronide-dPBD-PEG5-NH2 TFA, as a proagent of cIRCR201-dPBD, reduces side effects. β-Glucuronide-dPBD-PEG5-NH2 TFA can induce apoptosis and arrest cell cycle. β-Glucuronide-dPBD-PEG5-NH2 TFA has antitumor activity. | |||||||||||||||||||||
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Keywords
