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12

Inhibitors & Agonists

2

Natural
Products

Cat. No. Product Name Target Research Areas Chemical Structure
  • HY-139338
    Erlose
    1 Publications Verification

    		 Glycosidase Others
    Erlose is a trisaccharide sucrose derivative and low-calorie sweetener synthesized from glucose and sucrose via an α-glucosidase-mediated transglycosylation reaction. Erlose is often used as a marker to identify whether honey is adulterated with artificial sucrose. Erlose has approximately half the sweetness of sucrose but a similar taste, and it effectively inhibits crystal formation and browning reactions during food heat treatment .
    Erlose
  • HY-15046
    EB-47
    5 Publications Verification

    		 PARP Cardiovascular Disease Inflammation/Immunology
    EB-47, a potent and selective PARP-1/ARTD-1 inhibitor with an IC50 value of 45 nM, shows modest potency against ARTD5 with an IC50 value of 410 nM. EB-47 mimics the substrate NAD + and extends from the nicotinamide to the adenosine subsite .
    EB-47
  • HY-108631
    EB-47 dihydrochloride
    5 Publications Verification

    		 PARP Inflammation/Immunology
    EB-47 dihydrochloride, a potent and selective PARP-1/ARTD-1 inhibitor with an IC50 value of 45 nM, shows modest potency against ARTD5 with an IC50 value of 410 nM. EB-47 mimics the substrate NAD +?and extends from the nicotinamide to the adenosine subsite .
    EB-47 dihydrochloride
  • HY-N8326
    Maltononaose

    		Others Others
    Maltononaose is a linear oligosaccharide consisting of 9 glucose units linked by alpha-1, 4-glucoside bonds. Maltononaose is used as a substrate to study the subsites affinity of glucoamylase. Maltononaose can be used to determine the activity of amylase and to optimize the process of starch hydrolysis .
    Maltononaose
  • HY-139866
    SARS-CoV-2-IN-9

    		SARS-CoV Infection
    SARS-CoV-2-IN-9 is an inhibitor binding to subsites S1 and S2 in SARS-CoV-2 main protease.
    SARS-CoV-2-IN-9
  • HY-162674
    MERS-CoV-IN-2

    		SARS-CoV Infection
    MERS-CoV-IN-2 (compound 3c) is a MERS-CoV 3CLpro inhibitor (IC50=17nM). MERS-CoV-IN-2 inhibits the activity of the 3CLpro enzyme by binding to the active site of the enzyme, specifically the S4 subsite, thereby exhibiting antiviral activity against SARS-CoV-2 and MERS-CoV .
    MERS-CoV-IN-2
  • HY-125494A
    Droxinavir

    SC-55389A free base

    		 HIV HIV Protease Infection
    Droxinavir (SC-55389A free base) is an HIV-1 protease inhibitor. Droxinavir binds to the S2 and S2' subsites of HIV-1 protease, and this interaction is regulated by protease amino acid residue 88, where the N88S mutation confers viral resistance. Droxinavir can be used in studies related to human immunodeficiency virus type 1 infection .
    Droxinavir
  • HY-E70393I
    Bovine Factor IXa Beta

    		Others Others
    Bovine Factor IXa Beta is an inactive and highly specific enzyme, with a minimal extended substrate recognition site and a preference for particular amino acid residues at specific subsites. Bovine Factor IXa Beta plays a role in the blood coagulation cascade .
    Bovine Factor IXa Beta
  • HY-182565
    PSI-112

    		Plasminogen/Plasmin Cancer
    PSI-112 is a YO-class μPlm inhibitor, with IC50 values of 0.38 μM, 1.48 μM and 0.37 μM against the wild-type, F587A mutant and K607A mutant, respectively. PSI-112 shows low affinity for uPA. PSI-112 can be used in cancer research .
    PSI-112
  • HY-183956
    GC813

    		SARS-CoV Infection
    GC813 is a MERS-CoV 3CL protease (3CLpro) and MERS-CoV main protease (Mpro) inhibitor. GC813 can be used for the research of middle east respiratory syndrome .
    GC813
  • HY-108631R
    EB-47 dihydrochloride (Standard)

    		Reference Standards PARP Inflammation/Immunology
    EB-47 dihydrochloride (Standard) is the analytical standard of EB-47 (dihydrochloride) (HY-108631). This product is intended for research and analytical applications. EB-47 dihydrochloride, a potent and selective PARP-1/ARTD-1 inhibitor with an IC50 value of 45 nM, shows modest potency against ARTD5 with an IC50 value of 410 nM. EB-47 mimics the substrate NAD+ and extends from the nicotinamide to the adenosine subsite .
    EB-47 dihydrochloride (Standard)
  • HY-181888
    GRL-142

    		HIV HIV Protease Infection
    GRL-142 is a potent HIV-1 protease inhibitor capable of crossing the blood-brain barrier. GRL-142 exhibits extremely high inhibitory activity against both wild-type and multidrug-resistant strains (IC50=0.0094 nM). GRL-142 acts synergistically with the P2/P2' segments via a unique scaffold binding mechanism, utilizes fluorine-mediated stable interactions to maintain its bioactive conformation, adapts to p51 HIV-1 protease mutants, and maintains the flap-closed state by directly acting on the flap tip residues. GRL-142 disrupts the flap-water hydrogen bond network of wild-type protease, thereby effectively blocking viral replication. GRL-142 can be used to study HIV-1 infection and the associated neurocognitive disorder (HAND) .
    GRL-142

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