Antibacterial agent 361
Antibacterial agent 361 is an antibacterial agent as well as a membrane-permeable prodrug. Antibacterial agent 361 binds to subsite I of the linear motif binding pocket of the Escherichia coli sliding clamp, disrupts the interaction between the sliding clamp and its chaperone protein, and inhibits sliding clamp-dependent in vitro DNA replication. Antibacterial agent 361 can be used in the research of bacterial infections.
For research use only. We do not sell to patients.
- CAS No.: 874968-47-5
- Formula: C15H16ClNO2
- Molecular Weight:277.75
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Storage:
Please store the product under the recommended conditions in the Certificate of Analysis.
To place orders, for customer services and technical support, please contact: MedChemExpress USA
Tel: 609-228-6898 E-mail: [email protected] [email protected]
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Biological Activity
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Chemical Information
- Purity & Documentation
- References
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Help & FAQs
Biological Activity
Antibacterial agent 361 (compound 10) inhibits the interaction between the Escherichia coli sliding clamp and the consensus linear motif peptide, with a Ki of approximately 499 μM and an IC50 of approximately 899 μM[1].
Antibacterial agent 361 is a prodrug of compound 8[1].
Antibacterial agent 361 (24 h) inhibits the growth of E. coli DH5α, B. subtilis SU5 and S. aureus NCTC8325 with an MIC of 22 μg/mL; it exhibits an MIC of 43 μg/mL against A. baylyi ADP1[1].
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
Chemical Information
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CAS No. 874968-47-5
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Molecular Weight 277.75
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Formula C15H16ClNO2
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SMILES
O=C(OCC)C1CC=2C=3C=C(Cl)C=CC3NC2CC1
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Shipping
Room temperature in continental US; may vary elsewhere.
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Storage
Please store the product under the recommended conditions in the Certificate of Analysis.
Purity & Documentation
References
Calculators
Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
Antibacterial agent 361 Related Classifications
HY-187106 Related Classifications
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- Antibacterial agent 361
- 874968-47-5
- Antibacterial agent361
- Antibacterial agent-361
- Bacterial
- Drug Intermediate
- B. subtilis SU5
- S. aureus NCTC8325
- Gram-positive bacterial species
- subsite I
- E. coli DH5α
- DNA replication
- Gram-negative bacterial species
- E. coli sliding clamp
- linear-motif-binding pocket
- clamp-partner protein interactions
- Inhibitor
- inhibitor
- inhibit