3049658-41-2
3049658-41-2
Chemical Structure
MERS-CoV-IN-2
- CAS No.: 3049658-41-2
- Formula:C26H35ClN4O6
- Molecular Weight:535.03
InChIKey: QGNQEKJDMJPWOT-QESAQDPVSA-N
SMILES: O=C(N[C@H](C(N[C@H](C=O)C[C@H]1C(NCC1)=O)=O)CC(C)C)OC[C@@H](N2CC3=CC=CC(Cl)=C3)CCC2=O
Biological Activity: MERS-CoV-IN-2 (compound 3c) is a MERS-CoV 3CLpro inhibitor (IC50=17nM). MERS-CoV-IN-2 inhibits the activity of the 3CLpro enzyme by binding to the active site of the enzyme, specifically the S4 subsite, thereby exhibiting antiviral activity against SARS-CoV-2 and MERS-CoV[1].
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MERS-CoV-IN-2 | MERS-CoV-IN-2 (compound 3c) is a MERS-CoV 3CLpro inhibitor (IC50=17nM). MERS-CoV-IN-2 inhibits the activity of the 3CLpro enzyme by binding to the active site of the enzyme, specifically the S4 subsite, thereby exhibiting antiviral activity against SARS-CoV-2 and MERS-CoV. | |||||||||||||||||||||
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References
Keywords
