2. Anti-infection
  3. SARS-CoV Virus Protease
  4. AD05

AD05 is a SARS-CoV-2 main protease (Mpro) inhibitor with an IC50 of 306.5 nM. AD05 exhibits antiviral activity against wild-type SARS-CoV-2 in host cells without inducing significant cytotoxicity. AD05 can be used in studies related to SARS-CoV-2 infection.

For research use only. We do not sell to patients.

AD05

AD05 Chemical Structure

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AD05 Related Antibodies

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Description

AD05 is a SARS-CoV-2 main protease (Mpro) inhibitor with an IC50 of 306.5 nM. AD05 exhibits antiviral activity against wild-type SARS-CoV-2 in host cells without inducing significant cytotoxicity. AD05 can be used in studies related to SARS-CoV-2 infection[1].

In Vitro

AD05 inhibits wild-type SARS-CoV-2 replication in Vero E6 cells with an EC50 of 3.22 μM[1].
AD05 shows no significant cytotoxicity in Vero E6 cells, with a CC50 > 100 μM[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

AD05 Related Antibodies
Molecular Weight

414.91

Formula

C17H23ClN4O4S
SMILES

CC(C[C@@H](C(N[C@@H](C[C@@H]1CCNC1=O)C=O)=O)NC(C2=CSC(Cl)=N2)=O)C
Shipping

Room temperature in continental US; may vary elsewhere.
Storage

Please store the product under the recommended conditions in the Certificate of Analysis.
Purity & Documentation
References
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AD05 Related Classifications

  • Molarity Calculator

  • Dilution Calculator

The molarity calculator equation

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

Mass   Concentration   Volume   Molecular Weight *
= × ×

The dilution calculator equation

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

This equation is commonly abbreviated as: C1V1 = C2V2

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
× = ×
C1   V1   C2   V2
Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

AD05AD 05AD-05SARS-CoVVirus ProteaseSARS coronavirusVero E6 cellsS1 subsitesSARS-CoV-2 Mpromammalian cellsCys145S2 subsiteswild-type SARS-CoV-2host cellsS3/4 subsitesSARS-CoV-2 main proteaseInhibitorinhibitorinhibit

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