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Cat. No.: HY-184146

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AD05

AD05 is a SARS-CoV-2 main protease (M^pro) inhibitor with an IC₅₀ of 306.5 nM. AD05 exhibits antiviral activity against wild-type SARS-CoV-2 in host cells without inducing significant cytotoxicity. AD05 can be used in studies related to SARS-CoV-2 infection.

For research use only. We do not sell to patients.

Formula: C₁₇H₂₃ClN₄O₄S
Molecular Weight:414.91

Storage:

Please store the product under the recommended conditions in the Certificate of Analysis.

AD05 Chemical Structure

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Top Publications Citing

Use of MCE Products

Fluorescent Dye

Strong Fluorescence Signal / Multi-Disciplinary Applications / High Fluorescence Specificity

Biological Activity
- Description
- In Vitro
Chemical Information
Purity & Documentation
References
Calculators
Help & FAQs
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Bioz

Biological Activity

Description

In Vitro

AD05 inhibits wild-type SARS-CoV-2 replication in Vero E6 cells with an EC₅₀ of 3.22 μM^[1].
AD05 shows no significant cytotoxicity in Vero E6 cells, with a CC₅₀ > 100 μM^[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Chemical Information

Molecular Weight 414.91
Formula C₁₇H₂₃ClN₄O₄S
SMILES

CC(C[C@@H](C(N[C@@H](C[C@@H]1CCNC1=O)C=O)=O)NC(C2=CSC(Cl)=N2)=O)C
Shipping

Room temperature in continental US; may vary elsewhere.
Storage

Please store the product under the recommended conditions in the Certificate of Analysis.

Purity & Documentation

Handling Instructions (2659 KB)

References

[1]. Yin W, et al. Design, Synthesis, and Evaluation of Novel Thiazole-Based Peptidomimetic Compounds as Potent SARS-CoV-2 Main Protease Covalent Inhibitors. ACS Infect Dis. 2026 Jun 12;12(6):1915-1923.
[Content Brief]

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Help & FAQs

How should lyophilized recombinant proteins be reconstituted and stored?

1. Before opening the cap, centrifuge the vial at 13000 rpm for 20-30 seconds. This step will ensure that any lyophilized powder that may have adhered to the cap or walls is collected at the bottom of the vial, minimizing the risk of product loss.

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100 mg

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