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1642147-15-6

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1 Results for "1642147-15-6" in MCE Product Catalog:

Cat. No.: HY-160969
CAS No.: 1642147-15-6
Research Areas:  

Cancer

Spiro-duocarmycin is a DNA minor groove N3-adenine alkylating agent. Spiro-duocarmycin exerts cytotoxic effects via DNA alkylation. Spiro-duocarmycin is the active spirocyclized form of seco-DUBA, which is incorporated as an inactive prodrug into the linker-drug construct of antibody-drug conjugates (ADCs). DUBA serves as an ADC payload that can be conjugated with monoclonal antibodies to synthesize antibody-drug conjugates (ADCs) .
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