1 Result for "

2-Oxokolavenol

" in MedChemExpress (MCE) Product Catalog:
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1 Results for "2-Oxokolavenol" in MCE Product Catalog:

2-Oxokolavenol
2-Oxokolavenol
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Cat. No.: HY-N1749
CAS No.: 130395-82-3
Category:  

Terpenoids Aglaia lawii (Wight) C. J. Saldanha & Ramamorthy Diterpenoids Plants Meliaceae

Target:  

FXR

2-Oxokolavenol is a selective agonist targeting the farnesoid X receptor (FXR), with an EC50 of ~3.7 μM. 2-Oxokolavenol exerts its activity against Acetaminophen (HY-66005)-induced hepatocyte damage in an FXR-dependent manner by binding to the FXR ligand-binding pocket, recruiting co-activators, and inducing FXR transcriptional activity. 2-Oxokolavenol can be naturally extracted from Aglaia spectabilis (a plant of the Aglaia genus in the Meliaceae family) and can be used in research related to liver diseases .
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