2 Results for "

22149-35-5

" in MedChemExpress (MCE) Product Catalog:
Products (2)

2 Results for "22149-35-5" in MCE Product Catalog:

Kaempferol 3-O-gentiobioside
Kaempferol 3-O-gentiobioside
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Cat. No.: HY-N1510
CAS No.: 22149-35-5
Category:  

Flavonols Flavonoids Sauropus spatulifolius Beille Metabolic Disease Phenols Polyphenols Euphorbiaceae Plants Disease Research Fields

Target:  

Glycosidase Notch Toll-like Receptor (TLR) NF-κB Mucin Reactive Oxygen Species (ROS) Bacterial TGF-beta/Smad Anaplastic lymphoma kinase (ALK)

Kaempferol 3-O-gentiobioside is an orally active flavonoid, with a Ka value of 57 µM against human NOTCH1 and an IC50 value of 50 μM against α-glucosidase. Kaempferol 3-O-gentiobioside inhibits the NOTCH signaling pathway. It downregulates the expression of TLR4 and NLRP3, and suppresses the activation and nuclear translocation of NF-κB. Kaempferol 3-O-gentiobioside inhibits the expression of MUC5AC, reduces nitrite and ROS levels, and attenuates excessive mucus secretion. It exhibits antibacterial activity, reducing the formation and growth of MRSA biofilms. Kaempferol 3-O-gentiobioside blocks the TGF-β/ALK5/Smad signaling pathway and inhibits epithelial-mesenchymal transition. It suppresses the proliferation, migration, invasion and metastatic growth of tumor cells. Kaempferol 3-O-gentiobioside alleviates airway inflammation and mucus hypersecretion in mice with allergic asthma . It reduces the volume of ovarian cancer xenografts in mice. Kaempferol 3-O-gentiobioside can be used in research related to allergic asthma, diabetes, MRSA infection, breast cancer, gastric cancer and ovarian cancer .
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Kaempferol 3-O-gentiobioside (Standard)
Kaempferol 3-O-gentiobioside (Standard)
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Cat. No.: HY-N1510R
CAS No.: 22149-35-5
Category:  

Flavonols Flavonoids Sauropus spatulifolius Beille Phenols Polyphenols Euphorbiaceae Plants

Target:  

Reference Standards Glycosidase

Kaempferol 3-O-gentiobioside (Standard) is the analytical standard of Kaempferol 3-O-gentiobioside. This product is intended for research and analytical applications. Kaempferol 3-O-gentiobioside is a flavonoid isolated from C. alata leaves with antidiabetic activity. Kaempferol 3-O-gentiobioside possesses activity against α-glucosidase and displays carbohydrate enzyme inhibitory effect with an IC50 of 50.0 μM .
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