1 Result for "

3056647-52-7

" in MedChemExpress (MCE) Product Catalog:
Products (1)

1 Results for "3056647-52-7" in MCE Product Catalog:

Cat. No.: HY-168135
CAS No.: 3056647-52-7
Target:  

PROTACs c-Met/HGFR

Research Areas:  

Cancer

PROTAC c-Met degrader-1 is a selective and orally active c-Met PROTAC degrader with a DC50 of 6.21 nM against c-Met. PROTAC c-Met degrader-1 induces CRBN-dependent ubiquitination and proteasomal degradation of c-Met. PROTAC c-Met degrader-1 induces G0/G1 phase arrest in c-Met-dependent cancer cells. PROTAC c-Met degrader-1 kills c-Met-dependent cancer cells. PROTAC c-Met degrader-1 inhibits tumor growth in animal models. PROTAC c-Met degrader-1 can be used for the research of gastric cancer .
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