3056647-52-7
Chemical Structure
PROTAC c-Met degrader-1
- CAS No.: 3056647-52-7
- Formula:C45H41FN10O5
- Molecular Weight:820.87
InChIKey: YSTQEPBPZJFTEG-UHFFFAOYSA-N
SMILES: FC1=C(C=CC(C(C=N2)=NN3C2=NC=C3CC4=CC5=C(C=C4)N=CC=C5)=C1)C(N6CCC(CN7CCN(C8=CC9=C(C=C8)C(N(C9=O)C(C(N%10)=O)CCC%10=O)=O)CC7)CC6)=O
Biological Activity: PROTAC c-Met degrader-1 is a selective and orally active c-Met PROTAC degrader with a DC50 of 6.21 nM against c-Met. PROTAC c-Met degrader-1 induces CRBN-dependent ubiquitination and proteasomal degradation of c-Met. PROTAC c-Met degrader-1 induces G0/G1 phase arrest in c-Met-dependent cancer cells. PROTAC c-Met degrader-1 kills c-Met-dependent cancer cells. PROTAC c-Met degrader-1 inhibits tumor growth in animal models. PROTAC c-Met degrader-1 can be used for the research of gastric cancer[1].
| Cat. No. | Product Name | Purity | Description | Pricing | |||||||||||||||||||
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
|
|
PROTAC c-Met degrader-1 | 98.48% | PROTAC c-Met degrader-1 is a selective and orally active c-Met PROTAC degrader with a DC50 of 6.21 nM against c-Met. PROTAC c-Met degrader-1 induces CRBN-dependent ubiquitination and proteasomal degradation of c-Met. PROTAC c-Met degrader-1 induces G0/G1 phase arrest in c-Met-dependent cancer cells. PROTAC c-Met degrader-1 kills c-Met-dependent cancer cells. PROTAC c-Met degrader-1 inhibits tumor growth in animal models. PROTAC c-Met degrader-1 can be used for the research of gastric cancer. | ||||||||||||||||||||
|
loading...
/
|
|||||||||||||||||||||||
