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2 Results for "
5-OxoETE methyl ester
" in MedChemExpress (MCE) Product Catalog:
Products (2)
2 Results for "5-OxoETE methyl ester" in MCE Product Catalog:
Cat. No.: HY-141434
CAS No.: 74785-00-5
Research Areas:
5-OxoETE methyl ester is the agonist for oxoeicosanoid receptor 1 (OXER1). 5-OxoETE methyl ester binds to OXER1, and activates downstream signaling pathways β-arrestin recruitment with an EC50 of 1.54 µM .
Cat. No.: HY-184965
CAS No.: 2020058-38-0
Target:
Research Areas:
S-Y048 is an orally active OXE receptor-selective antagonist with picomolar-level IC50 values (0.02-30 nM) and pIC50 values of (10.47-10.81) against human receptors. S-Y048 selectively blocks the 5-oxo-ETE signaling pathway, inhibits actin polymerization, calcium mobilization, leukocyte migration, as well as allergen-induced leukocyte infiltration in skin and lung tissues, and reduces mucin-producing bronchial epithelial cells. S-Y048 undergoes benzyl, N-methyl and α-hydroxylation reactions to form metabolites in monkeys. S-Y048 can be used in research related to asthma, allergic asthma, allergic eosinophilic diseases, atopic dermatitis and allergic rhinitis .
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