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75483-04-4

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Cat. No.: HY-124834
CAS No.: 75483-04-4
Target:  

Keap1-Nrf2 Apoptosis

Research Areas:  

Cancer

Nrf2 activator-10 (Compound AI-1) is a PI3K-dependent inducer for antioxidant response element (ARE) (EC50 is 2.7 μM) and an activator for Nrf2. Nrf2 activator-10 modifies Keap1, blocks Cul3-Keap1 ubiquitin ligase complex, activates the transcription of Nrf2. Nrf2 activator-10 protects cells from H2O2-induced apoptosis.
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