2 Results for "

863971-19-1

" in MedChemExpress (MCE) Product Catalog:
Products (2)

2 Results for "863971-19-1" in MCE Product Catalog:

8
8 Cited Publications
Cat. No.: HY-15578
CAS No.: 863971-19-1
Purity:  99.96%
Synonyms: Maleimidocaproyl monomethylauristatin F
Research Areas:  

Cancer

McMMAF (Maleimidocaproyl monomethylauristatin F) is an active molecule linker for ADC, made by coupling the powerful microtubule inhibitor Monomethyl auristatin F (MMAF) (HY-15579) with the protecting group maleimidocaproyl. McMMAF can be conjugated with anti-BCMA antibodies to form J6M0-mcMMAF, promoting apoptosis and inhibiting tumor growth .
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Cat. No.: HY-15578G
CAS No.: 863971-19-1
Synonyms: Maleimidocaproyl monomethylauristatin F (GMP)
McMMAF GMP is a GMP grade McMMAF (HY-15578). McMMAF is a protective group (maleimidocaproyl)-conjugated MMAF, which is a potent tubulin polymerization inhibitor. McMMAF can be used as a agent-linker for antibody-drug conjugates (ADC). McMMAF is uncleavable, and must be internalized and degraded within a cell, releasing cysteine-McMMAF as the active agent .
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