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Targeted therapy! The Capetin Prize winning "Click Chemistry" can be used like this!Targeted therapy! The Nobel Prize winning "Click Chemistry" can be used like this!2025-02-06
13 Results for "
ADA Inhibitors
" in MedChemExpress (MCE) Product Catalog:
Products (13)
13 Results for "ADA Inhibitors" in MCE Product Catalog:
5
5 Cited Publications
Research Areas:
Infection Cardiovascular Disease Neurological Disease Cancer
EHNA hydrochloride is a potent and selective dual inhibitor of cyclic nucleotide phosphodiesterase 2 (PDE2)(IC50=4 μM) and adenosine deaminase (ADA). EHNA hydrochloride exerts a concentration inhibition of the cGMP-stimulated PDE II (cGs-PDE)(IC50:0.8 μM (human), 2 μM (porcine myocardium)), but has smaller inhibitory effect on the unstimulated PDE2 activity. EHNA hydrochloride play roles in mediating diverse pharmacological responses, including antiviral, antitumour and antiarrhythmic effects .
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SGF29-IN-1 (Compound Cpd_DC60) is a selective inhibitor for Spt-Ada-Gcn5 acetyltransferase (SAGA)–associated factor 29 (SGF29)-Tudor domain. SGF29-IN-1 exhibits activity against leukemia .
Cat. No.: HY-N7368
CAS No.: 55366-56-8
Category:
Flavonols other families Flavonoids Neurological Disease Phenols Polyphenols Plants Disease Research Fields Inflammation/Immunology
Target:
Cat. No.: HY-17377
CAS No.: 599179-03-0
Synonyms: SCH-417690 maleate; SCH-D maleate
Research Areas:
Vicriviroc maleate (SCH-417690 maleate; SCH-D maleate) is a potent, selective, oral bioavailable and CNS penetrated antagonist of CCR5, with a Ki of 2.5 nM, and also inhibits HIV-1 in PBMC cells, with IC90s of 3.3 nM (JrFL), 2.8 nM (ADA-M), 1.8 nM (301657), 4.9 nM (JV1083) and 10 nM (RU 570).
Cat. No.: HY-117260
CAS No.: 11033-22-0
Category:
Infection Microorganisms Antibiotics Disease Research Antibacterial Anticancer Disease Research Fields Other Antibiotics
Target:
Target:
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1-Deazaadenosine is a potent Adenosine deaminase (ADA) inhibitor with a Ki value of 0.66 μM. 1-Deazaadenosine exhibits anti-cancer activities in vitro and has the potential to be a chemotherapy agent for lymphoproliferative disorders .
Cat. No.: HY-103160B
CAS No.: 51350-19-7
Research Areas:
Infection Cardiovascular Disease Neurological Disease Cancer
EHNA is a potent and selective dual inhibitor of cyclic nucleotide phosphodiesterase 2 (PDE2)(IC50=4 μM) and adenosine deaminase (ADA). EHNA exerts a concentration inhibition of the cGMP-stimulated PDE II (cGs-PDE)(IC50:0.8 μM (human), 2 μM (porcine myocardium)), but has smaller inhibitory effect on the unstimulated PDE2 activity. EHNA play roles in mediating diverse pharmacological responses, including antiviral, antitumour and antiarrhythmic effects .
Cat. No.: HY-19130
CAS No.: 143153-93-9
Target:
Research Areas:
BW-534U87 is an orally active adenosine A1 receptor agonist and competitive adenosine deaminase (ADA) inhibitor (Ki=7 μM). BW-534U87 elevates brain adenosine levels and suppresses epileptiform activity. BW-534U87 demonstrate anticonvulsant efficacy in animal seizure models. BW-534U87 is promising for research of epilepsy and adenosine-related neuropsychiatric disorders .
Research Areas:
Bupirimate is a systemic fungicide that inhibits adenosine deaminase (ADA). Bupirimate is widely used in the cultivation of fruit trees, vegetables, flowers, and other crops to control powdery mildew .
Cat. No.: HY-133216R
CAS No.: 41483-43-6
Research Areas:
Bupirimate (Standard) is the analytical standard of Bupirimate (HY-133216). This product is intended for research and analytical applications. Bupirimate is a systemic fungicide that inhibits adenosine deaminase (ADA). Bupirimate is widely used in the cultivation of fruit trees, vegetables, flowers, and other crops to control powdery mildew .
Cat. No.: HY-N7368R
CAS No.: 55366-56-8
Category:
Flavonols other families Flavonoids Phenols Polyphenols Plants
Cat. No.: HY-103160AR
CAS No.: 58337-38-5
Research Areas:
Infection Cardiovascular Disease Neurological Disease Cancer
EHNA hydrochloride (Standard) is the analytical standard of EHNA hydrochloride (HY-103160A). This product is intended for research and analytical applications. EHNA hydrochloride is a potent and selective dual inhibitor of cyclic nucleotide phosphodiesterase 2 (PDE2)(IC50=4 μM) and adenosine deaminase (ADA). EHNA hydrochloride exerts a concentration inhibition of the cGMP-stimulated PDE II (cGs-PDE)(IC50:0.8 μM (human), 2 μM (porcine myocardium)), but has smaller inhibitory effect on the unstimulated PDE2 activity. EHNA hydrochloride play roles in mediating diverse pharmacological responses, including antiviral, antitumour and antiarrhythmic effects .
Cat. No.: HY-181065
CAS No.: 3099617-79-2
Target:
Research Areas:
LS-170 is a YEATS2 YEATS domain inhibitor with an IC50 of 0.14 μM. LS-170 displays selectivity for the YEATS2 YEATS domain over other YEATS domain family members and other epigenetic 'reader' and 'eraser' proteins. LS-170 reduces chromatin occupancy of the Ada-two-A-containing (ATAC) complex, decreases ATAC-dependent histone acetylation levels, and downregulates expression of ATAC-governed genes. LS-170 suppresses tumor growth in a lung cancer mouse model. LS-170 can be used for the research of non-small cell lung cancer .
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Protocols
Targeted therapy! The Capetin Prize winning "Click Chemistry" can be used like this!Targeted therapy! The Nobel Prize winning "Click Chemistry" can be used like this!A suitable model is crucial in drug screening experiments. Organs can mimic the three-dimensional functional structure of internal organs, have similar spatial organization to corresponding organs, maintain some key characteristics, and reproduce some physiological functions. They are widely used for modeling and personalized drug screening physiological functions.2025-02-06
