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Acridine

" in MedChemExpress (MCE) Product Catalog:

40

Inhibitors & Agonists

13

Fluorescent Dye

1

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1

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Cat. No. Product Name Target Research Areas Chemical Structure
  • HY-101879
    Acridine Orange hydrochloride
    Maximum Cited Publications
    38 Publications Verification

    		 DNA Stain Parasite Fluorescent Dye Others
    Acridine Orange hydrochloride is a cell-penetrable nucleic acid-selective fluorescent dye. Acridine Orange hydrochloride produces orange fluorescence when it binds to ssDNA or RNA, and green fluorescence when it binds to dsDNA (Ex: 488 nM; Em: green fluorescence at 530 nm, orange fluorescence at 640 nm) .
    Acridine Orange hydrochloride
  • HY-D0993
    Acridine Orange 10-Nonyl Bromide
    4 Publications Verification

    NonylAcridine orange

    		 Fluorescent Dye Others
    Acridine Orange 10-Nonyl Bromide is a fluorescent probe for cardiolipin (λex: 489 nm, λem: 525 nm).
    Acridine Orange 10-Nonyl Bromide
  • HY-D0952
    Acridine Orange base
    Maximum Cited Publications
    38 Publications Verification

    		 Parasite Others
    Acridine Orange base is a cell-permeable fluorescent dye that stains organisms (bacteria, parasites, viruses, etc.) bright orange and, when used under appropriate conditions (pH=3.5, Ex=460 nm), distinguishes human cells in green for detection by fluorescence microscopy. Acridine Orange base fluoresces green when bound to dsDNA (Ex=488, Em=520-524) and red when bound to ssDNA (Ex=457, Em=630-644) or ssRNA (Ex=457, Em=630-644), also can be used in cell cycle assays .
    Acridine Orange base
  • HY-100575
    Acriflavine
    5+ Cited Publications

    Acriflavinium chloride 3,6-Acridinediamine mix

    		 Environmental Pollutants Fluorescent Dye Monocarboxylate Transporter Bacterial Fungal HIF/HIF Prolyl-Hydroxylase SARS-CoV Infection Cancer
    Acriflavine (Acriflavinium chloride) is a fluorescent acridine dye that can be used to label nucleic acid. Acriflavine is an antiseptic agent. Acriflavine is a potent HIF-1 inhibitor that prevents the dimerization of HIF-1α and HIF-1β subunits. Acriflavine inhibits the interaction between monocarboxylate transporter 4 (MCT4) and Basigin. Acriflavine is used in cancer research, such as breast cancer, brain tumor and chronic myeloid leukemia. Acriflavine is a potent papain-like protease (PLpro) inhibitor, which inhibits SARS-CoV-2 .
    Acriflavine
  • HY-W088075
    Acriflavine hydrochloride
    5+ Cited Publications

    Acriflavinium chloride hydrochloride

    		 Fluorescent Dye HIF/HIF Prolyl-Hydroxylase Bacterial SARS-CoV Monocarboxylate Transporter Fungal Infection Cancer
    Acriflavine (Acriflavinium chloride) hydrochloride is a fluorescent acridine dye that can be used to label nucleic acid. Acriflavine hydrochloride is an antiseptic agent. Acriflavine hydrochloride is a potent HIF-1 inhibitor that prevents the dimerization of HIF-1α and HIF-1β subunits. Acriflavine hydrochloride inhibits the interaction between monocarboxylate transporter 4 (MCT4) and Basigin. Acriflavine hydrochloride is used in cancer research, such as breast cancer, brain tumor and chronic myeloid leukemia. Acriflavine hydrochloride is a potent papain-like protease (PLpro) inhibitor, which inhibits SARS-CoV-2 .
    Acriflavine hydrochloride
  • HY-D0996
    LDS-751

    		DNA Stain Others
    Lds-751 is a nucleic acid stain that mainly detects DNA. Lds-751 is a nucleic acid stain that mainly detects DNA. Lds-751 has a high affinity for DNA and fluorescence is enhanced after binding, but the maximum emission wavelength is 670nm. Lds-751 and Thiazole orange can be used for the differentiation of red blood cells, platelets, reticulocytes, and nucleated cells and can be stimulated at 488nm. Studies have shown that LDS-751 binds almost exclusively to mitochondria when incubated with nucleated living cells. After nucleated Acridine Orange (HY-101879) staining and LDS-751 treatment of cells, confocal microscopy revealed almost no co-location of the cells. Staining with Rhodamine 123 (HY-D0816), a dye known to bind polarized mitochondria, was almost identical to the pattern observed with LDS-751 .
    LDS-751
  • HY-D0942
    Acridine Orange zinc chloride salt
    35+ Cited Publications

    Euchrysine 3RX

    		 Parasite Fluorescent Dye DNA Stain Others
    Acridine Orange (Euchrysine 3RX) zinc chloride salt is a cell-penetrable nucleic acid-selective fluorescent dye. Acridine Orange zinc chloride salt produces orange fluorescence when it binds to ssDNA or RNA, and green fluorescence when it binds to dsDNA (Ex: 488 nM; Em: green fluorescence at 530 nm, orange fluorescence at 640 nm) .
    Acridine Orange zinc chloride salt
  • HY-B0883
    3,6-Diaminoacridine hemisulfate
    3 Publications Verification

    		 Bacterial Fluorescent Dye Potassium Channel DNA/RNA Synthesis Infection Neurological Disease Cancer
    3,6-Diaminoacridine hemisulfate is a multifunctional acridine compound. 3,6-Diaminoacridine hemisulfate is an acridine dye and also a DNA inserter. 3,6-Diaminoacridine hemisulfate is a potent broad-spectrum antibacterial agent. Its mechanism is to insert into bacterial DNA, interfering with replication and transcription, leading to bacterial lysis. 3,6-Diaminoacridine hemisulfate is a Kir3.2 potassium channel blocker and can be used to study the neurological phenotype of Down syndrome. 3,6-Diaminoacridine hemisulfate can penetrate the stratum corneum of the skin and accumulate in the cell nucleus. Long-term exposure may induce skin cancer or other malignant tumors .
    3,6-Diaminoacridine hemisulfate
  • HY-DY1038
    Acridine Orange hydrochloride (solution)

    		Fluorescent Dye Others
    Acridine Orange hydrochloride (solution) is a cell-penetrable nucleic acid-selective fluorescent dye. Acridine Orange hydrochloride produces orange fluorescence when it binds to ssDNA or RNA, and green fluorescence when it binds to dsDNA (Ex: 488 nM; Em: green fluorescence at 530 nm, orange fluorescence at 640 nm) .
    Solvent and Concentration: Sterile water: 10 mg/mL
    The 1 mL volume is defined as the base specification. All larger sizes correspond to incremental volumes of this base.
    Acridine Orange hydrochloride (solution)
  • HY-B1741
    3,6-Diaminoacridine
    3 Publications Verification

    		 Bacterial Fluorescent Dye DNA/RNA Synthesis Infection Cancer
    3,6-Diaminoacridine is a versatile acridine compound. 3,6-Diaminoacridine exerts antibacterial activity by intercalating into bacterial DNA, interfering with replication and transcription, and inducing bacterial lysis. 3,6-Diaminoacridine is an acridine dye and also a DNA intercalator .
    3,6-Diaminoacridine
  • HY-106991A
    Amustaline dihydrochloride

    S-303 dihydrochloride

    		 HIV Bacterial CHIKV Infection
    Amustaline (S-303) dihydrochloride, a nucleic acid-targeted alkylator, is an efficient pathogen inactivation agent for blood components containing red blood cells. Amustaline dihydrochloride has three components: an acridine anchor (an intercalator that targets nucleic acids non-covalently), an effector (a bis-alkylator group that reacts with nucleophiles), and a linker (a small flexible carbon chain containing a labile ester bond that hydrolyzes at neutral pH to yield non-reactive breakdown products) .
    Amustaline dihydrochloride
  • HY-W007771
    Acridone

    		Bacterial BCRP Infection Cancer
    Acridone is an organic compound based on the acridine skeleton. Acridone has antibacterial, antimalarial, antiviral and anti neoplastic activities .
    Acridone
  • HY-DY1078
    Acridine Orange 10-Nonyl Bromide (solution)

    		Fluorescent Dye Others
    Acridine Orange 10-Nonyl Bromide (solution) is a fluorescent probe for cardiolipin (λex: 489 nm, λem: 525 nm).
    Solvent and concentration: DMSO: 10 mM
    Acridine Orange 10-Nonyl Bromide (solution)
  • HY-U00460
    3,6-DMAD hydrochloride
    1 Publications Verification

    		 IRE1 Cancer
    3,6-DMAD hydrochloride, an acridine derivative, is a potent IRE1α-XBP1s pathway inhibitor. 3,6-DMAD hydrochloride promotes IL-6 secretion via the IRE1α-XBP1s pathway. 3,6-DMAD hydrochloride inhibits IRE1α oligomerization and endoribonuclease (RNase) activity. 3,6-DMAD hydrochloride can be used for research of cancer .
    3,6-DMAD hydrochloride
  • HY-W415108
    10-Methyl-9-(phenoxycarbonyl) acridinium trifluoromethanesulfonate

    		Fluorescent Dye Others
    10-Methyl-9-(phenoxycarbonyl) acridinium trifluoromethanesulfonate is an acridinium ester that produces fluorescent 10-methyl-9-acridone upon oxidation with hydrogen peroxide, persulfate, and other oxidants under alkaline conditions. 10-Methyl-9-(phenoxycarbonyl) acridinium trifluoromethanesulfonate can be used in chemiluminescent assays, enzyme, antigen, antibody, and hormone immunoassays, and for the detection of oxidants in environmental, biological, and pharmaceutical samples .
    10-Methyl-9-(phenoxycarbonyl) acridinium trifluoromethanesulfonate
  • HY-D0956
    Acridine yellow G

    		Fluorescent Dye Others
    Acridine yellow G is a multifunctional dye. Dyes are important tools in biological experiments. They can help researchers observe and analyze cell structures, track biomolecules, evaluate cell functions, distinguish cell types, detect biomolecules, study tissue pathology and monitor microorganisms. Their applications range from basic scientific research to clinical A wide range of diagnostics. Dyes are also widely used in traditional fields such as textile dyeing, as well as in emerging fields such as functional textile processing, food pigments and dye-sensitized solar cells.
    Acridine yellow G
  • HY-D1660
    Acridine homodimer

    NSC 219743

    		 DNA Stain Others
    Acridine homodimer (NSC 219743), acridine dimer, is a fluorescence dye. Acridine homodimer emits a blue-green fluorescence when bound to DNA. Acridine homodimer has extremely high affinity for AT-rich regions of nucleic acids, can be used for chromosome banding .
    Acridine homodimer
  • HY-U00460B
    3,6-DMAD dihydrochloride

    		IRE1 Cancer
    3,6-DMAD dihydrochloride, an acridine derivative, is a potent IRE1α-XBP1s pathway inhibitor. 3,6-DMAD dihydrochloride promotes IL-6 secretion via the IRE1α-XBP1s pathway. 3,6-DMAD dihydrochloride inhibits IRE1α oligomerization and endoribonuclease (RNase) activity. 3,6-DMAD dihydrochloride can be used for research of cancer .
    3,6-DMAD dihydrochloride
  • HY-171491
    NSP-DMAE-HEG-Giu-NHS

    		Fluorescent Dye Others
    NSP-DMAE-HEG-Giu-NHS (Fig.18) is an activated labeling reagent containing acridine ester, and it is a key component of Cyclosporine A (HY-B0579) tracers .
    NSP-DMAE-HEG-Giu-NHS
  • HY-W026644
    Acridine-9-carboxaldehyde

    Acridine-9-carbaldehyde

    		 Bacterial Infection Cancer
    Acridine-9-carboxaldehyde (Acridine-9-carbaldehyde) is a bioactive compound with potential antibacterial and antitumor activities. Acridine-9-carboxaldehyde is widely used as a building block in compound development to synthesize various bioactive derivatives. Acridine-9-carboxaldehyde exhibits significant cytotoxicity against certain cancer cells, making it an important candidate in cancer inhibition research.
    Acridine-9-carboxaldehyde
  • HY-146678
    HDAC6-IN-5

    		HDAC Amyloid-β Cholinesterase (ChE) Neurological Disease
    HDAC6-IN-5 (compound 11b) is a potent and BBB-penetrated HDAC6 inhibitor, with an IC50 of 0.025 μM. HDAC6-IN-5 exhibits strong inhibitory activity against Aβ1-42 self-aggregation and AChE, with IC50 values of 3.0 and 0.72 μM. HDAC6-IN-5 can enhance neurite outgrowth without significant neurotoxicity .
    HDAC6-IN-5
  • HY-146679
    HDAC6-IN-6

    		HDAC Amyloid-β Cholinesterase (ChE) Neurological Disease
    HDAC6-IN-6 (compound 6a) is a potent and BBB-penetrated HDAC6 inhibitor, with an IC50 of 0.025 μM. HDAC6-IN-6 exhibits strong inhibitory activity against Aβ1-42 self-aggregation and AChE, with IC50 values of 3.0 and 0.72 μM. HDAC6-IN-6 can enhance neurite outgrowth without significant neurotoxicity .
    HDAC6-IN-6
  • HY-B1741A
    3,6-Diaminoacridine dihydrochloride

    		Bacterial Fluorescent Dye Potassium Channel DNA/RNA Synthesis Infection Cancer
    3,6-Diaminoacridine dihydrochloride is a versatile acridine compound. 3,6-Diaminoacridine dihydrochloride exerts antibacterial activity by intercalating into bacterial DNA, interfering with replication and transcription, and inducing bacterial lysis. 3,6-Diaminoacridine dihydrochloride is an acridine dye and also a DNA intercalator .
    3,6-Diaminoacridine dihydrochloride
  • HY-106991AR
    Amustaline dihydrochloride (Standard)

    S-303 dihydrochloride (Standard)

    		 HIV Bacterial Reference Standards CHIKV Infection
    Amustaline (dihydrochloride) (Standard) is the analytical standard of Amustaline (dihydrochloride). This product is intended for research and analytical applications. Amustaline (S-303) dihydrochloride, a nucleic acid-targeted alkylator, is an efficient pathogen inactivation agent for blood components containing red blood cells. Amustaline dihydrochloride has three components: an acridine anchor (an intercalator that targets nucleic acids non-covalently), an effector (a bis-alkylator group that reacts with nucleophiles), and a linker (a small flexible carbon chain containing a labile ester bond that hydrolyzes at neutral pH to yield non-reactive breakdown products) .
    Amustaline dihydrochloride (Standard)
  • HY-W007771R
    Acridone (Standard)

    		Reference Standards Bacterial BCRP Infection Cancer
    Acridone (Standard) is the analytical standard of Acridone. This product is intended for research and analytical applications. Acridone is an organic compound based on the acridine skeleton. Acridone has antibacterial, antimalarial, antiviral and anti neoplastic activities .
    Acridone (Standard)
  • HY-101879R
    Acridine Orange hydrochloride (Standard)

    		DNA Stain Reference Standards Parasite Fluorescent Dye Others
    Acridine Orange hydrochloride (Standard) is the analytical standard of Acridine Orange hydrochloride (HY-101879). This product is intended for research and analytical applications. Acridine Orange hydrochloride is a cell-penetrable nucleic acid-selective fluorescent dye. Acridine Orange hydrochloride produces orange fluorescence when it binds to ssDNA or RNA, and green fluorescence when it binds to dsDNA (Ex: 488 nM; Em: green fluorescence at 530 nm, orange fluorescence at 640 nm) .
    Acridine Orange hydrochloride (Standard)
  • HY-182146
    Acridine phosphoramidite

    		DNA/RNA Synthesis Phosphoramidites Others
    Acridine phosphoramidite is a phosphoramidite that can be used in the synthesis of oligonucleotides.
    Acridine phosphoramidite
  • HY-W703411
    Dibenzo[a,h]acridine-d6

    		Isotope-Labeled Compounds Others
    Dibenzo[a,h]acridine-d6 is the deuterium labeled Dibenz[a,h]acridine (HY-W762000).
    Dibenzo[a,h]acridine-d6
  • HY-W112550
    3,3'-(Acridine-2,7-diyl)dibenzoic acid

    		MOFs Others
    3,3'-(Acridine-2,7-diyl)dibenzoic acid is a metal-organic framework (MOF).
    3,3'-(Acridine-2,7-diyl)dibenzoic acid
  • HY-W112262
    5,5'-(Acridine-2,7-diyl)diisophthalic acid

    		MOFs Others
    5,5'-(Acridine-2,7-diyl)diisophthalic acid is a metal-organic framework (MOF).
    5,5'-(Acridine-2,7-diyl)diisophthalic acid
  • HY-W586978
    9-(Pyridin-4-yl)acridine

    		MOFs Others
    9-(Pyridin-4-yl)acridine is a metal-organic framework (MOF).
    9-(Pyridin-4-yl)acridine
  • HY-W871908
    Boc-Aeg(Fmoc)-OH

    		Biochemical Assay Reagents Others
    Boc-Aeg(Fmoc)-OH is a Boc/Fmoc-protected 2-aminoethylglycine building block. Boc-Aeg(Fmoc)-OH facilitates solid-phase synthesis of acridine oligomers with a (2-aminoethyl)glycine backbone .
    Boc-Aeg(Fmoc)-OH
  • HY-W106029
    1,2,3,4-Tetrahydroacridine

    Acridine, 1,2,3,4-tetrahydro- 1,2,3,4-TetrahydroAcridine

    		 MOFs Others
    1,2,3,4-Tetrahydroacridine (Acridine, 1,2,3,4-tetrahydro- 1,2,3,4-Tetrahydroacridine) is a metal-organic framework (MOF).
    1,2,3,4-Tetrahydroacridine
  • HY-W249121
    3,7,11-Tribromo-5,5,9,9-tetramethyl-5,9-dihydroquinolino[3,2,1-de]acridine

    		MOFs Others
    3,7,11-Tribromo-5,5,9,9-tetramethyl-5,9-dihydroquinolino[3,2,1-de]acridine is a metal-organic framework (MOF).
    3,7,11-Tribromo-5,5,9,9-tetramethyl-5,9-dihydroquinolino[3,2,1-de]acridine
  • HY-W197393
    3,6-Diaminoacridine sulfate

    		Bacterial Fluorescent Dye Potassium Channel DNA/RNA Synthesis Infection Neurological Disease Cancer
    Proflavine sulfate is a multifunctional acridine compound. 3,6-Diaminoacridine sulfate is an acridine dye and also a DNA inserter. Proflavine sulfate is a potent broad-spectrum antibacterial agent, and its mechanism is to insert into bacterial DNA, interfering with replication and transcription, causing bacterial lysis. 3,6-Diaminoacridine sulfate is a Kir3.2 potassium channel blocker and can be used to study the neurological phenotype of Down syndrome. 3,6-Diaminoacridine sulfate can penetrate the stratum corneum of the skin and accumulate in the cell nucleus and long-term exposure may induce skin cancer or other malignant tumors .
    3,6-Diaminoacridine sulfate
  • HY-175755
    Ac-BIM-acid bromide

    		Amyloid-β Neurological Disease
    Ac-BIM-acid bromide is a derivative of Acridine. Ac-BIM-acid bromide significantly inhibits amyloid fibrillation. Ac-BIM-acid bromide modulates the structure of N-terminal region of Saccharomyces cerevisiae Stm1 protein (Stm1_N 1-113) and the amyloid morphology of human Aβ42 protein, inhibiting theirs growth. Ac-BIM-acid bromide can be used for Alzheimer’s disease research .
    Ac-BIM-acid bromide
  • HY-B1509A
    Trypaflavin

    		Parasite Infection Endocrinology
    Trypaflavin is an acridine compound and antimalarial agent. Trypaflavin invades germ cells. Trypaflavin induces aberrations in unfertilized oocytes. Trypaflavin increases the frequency of chromosomal aberrations. Trypaflavin shows weak mutagenicity. Trypaflavin is highly toxic to Leishmania, causing immediate lysis of the leptomonads .
    Trypaflavin
  • HY-177958
    ACS03

    		Lactate Dehydrogenase Glutathione S-transferase Cholinesterase (ChE) Parasite Infection Cancer
    ACS03 is a hybrid thiophene-acridine compound. ACS03 induces an increase in lactate dehydrogenase, glutathione S-transferase, and AChE activities. ACS03 has antileishmanial activity. ACS03 exhibits selective anti-cancer effects against colon carcinoma .
    ACS03
  • HY-B1509B
    Trypaflavin bromide

    		Parasite Infection Endocrinology
    Trypaflavin bromide is an orally active acridine compound and antimalarial agent. Trypaflavin bromide invades germ cells. Trypaflavin bromide induces aberrations in unfertilized oocytes. Trypaflavin bromide increases the frequency of chromosomal aberrations. Trypaflavin bromide shows weak mutagenicity. Trypaflavin bromide is highly toxic to Leishmania, causing immediate lysis of the leptomonads .
    Trypaflavin bromide
  • HY-100575R
    Acriflavine (Standard)

    Acriflavinium chloride 3,6-Acridinediamine mix (Standard)

    		 Fluorescent Dye Reference Standards HIF/HIF Prolyl-Hydroxylase Bacterial SARS-CoV Monocarboxylate Transporter Fungal Infection Cancer
    Acriflavine (Standard) is the analytical standard of Acriflavine (HY-100575). This product is intended for research and analytical applications. Acriflavine (Acriflavinium chloride) is a fluorescent acridine dye that can be used to label nucleic acid. Acriflavine is an antiseptic agent. Acriflavine is a potent HIF-1 inhibitor that prevents the dimerization of HIF-1α and HIF-1β subunits. Acriflavine inhibits the interaction between monocarboxylate transporter 4 (MCT4) and Basigin. Acriflavine is used in cancer research, such as breast cancer, brain tumor and chronic myeloid leukemia. Acriflavine is a potent papain-like protease (PLpro) inhibitor, which inhibits SARS-CoV-2 .
    Acriflavine (Standard)

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