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Isoforms Recommended:	Akt1 Akt1

Results for "

Akt-1

" in MedChemExpress (MCE) Product Catalog:

By Targets:	Akt (123) AMPK (9) Apoptosis (34) Autophagy (15) Bacterial (5) Bcl-2 Family (8) Bcr-Abl (1) c-Met/HGFR (2) c-Myc (1) CaMK (2) Casein Kinase (1) Caspase (11) CDK (4) COX (1) DGK (1) DNA-PK (3) DNA/RNA Synthesis (1) Drug Isomer (1) EGFR (5) Elastase (1) Endogenous Metabolite (1) Environmental Pollutants (1) Epigenetic Reader Domain (2) ERK (3) Estrogen Receptor/ERR (2) FAK (2) FOXO (2) Fungal (2) FXR (1) GSK-3 (5) HDAC (1) Histone Methyltransferase (1) HPV (1) HSP (3) HSV (2) Influenza Virus (1) Insulin Receptor (1) Interleukin Related (2) Isotope-Labeled Compounds (1) JNK (2) Keap1-Nrf2 (1) Ligands for E3 Ligase (1) MDM-2/p53 (7) MELK (1) Microtubule/Tubulin (2) Mitochondrial Metabolism (2) Mitophagy (1) MMP (3) mTOR (8) NF-κB (1) NO Synthase (2) Organoid (5) Oxidative Phosphorylation (1) p38 MAPK (3) Parasite (3) PARP (3) PDGFR (1) PDK-1 (4) PERK (2) PGC-1α (1) Phosphatase (1) PI3K (5) PKA (6) PKC (4) PPAR (2) Prostaglandin Receptor (1) PROTAC Linkers (1) PROTACs (7) PTEN (2) Ras (1) Reactive Oxygen Species (ROS) (6) Reference Standards (14) Ribosomal S6 Kinase (RSK) (9) ROCK (5) Ser/Thr Protease (2) SGK (2) Small Interfering RNA (siRNA) (4) SOD (1) SphK (1) Src (2) STAT (4) Survivin (1) Toll-like Receptor (TLR) (1) Trk Receptor (1) VEGFR (3)
By Research Areas:	Cancer (115) Cardiovascular Disease (6) Endocrinology (5) Infection (14) Inflammation/Immunology (17) Metabolic Disease (15) Neurological Disease (9)
Click Chemistry:	PROTAC Synthesis (1) Alkynes (1)
Oligonucleotides:	Rat Pre-designed siRNA Sets (1) Mouse Pre-designed siRNA Sets (1) Human Pre-designed siRNA Sets (2) Antisense Oligonucleotides (2) siRNAs (4)

139

Inhibitors & Agonists

Screening Libraries

Peptides

Natural
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Recombinant Proteins

Isotope-Labeled Compounds

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Click Chemistry

Oligonucleotides

Targets Recommended: Akt

Cat. No.	Product Name	Target	Research Areas	Chemical Structure

HY-15431

Capivasertib 80+ Cited Publications AZD5363	Akt Autophagy	Cancer
Capivasertib (AZD5363) is an orally active and potent *pan-AKT* kinase inhibitor with IC₅₀ of 3, 7 and 7 nM for *Akt1,Akt2* and *Akt3*, respectively.

HY-N0004

Oridonin Maximum Cited Publications 26 Publications Verification NSC-250682; Isodonol	Akt Bacterial Ligands for E3 Ligase	Infection Inflammation/Immunology Cancer
Oridonin (NSC-250682), a diterpenoid isolated from Rabdosia rubescens, acts as an inhibitor of *AKT, with IC₅₀s of 8.4 and 8.9 μM for AKT1* and AKT2; Oridonin possesses anti-tumor, anti-bacterial and anti-inflammatory effects.

HY-15186

Ipatasertib 55+ Cited Publications GDC-0068; RG7440	Organoid Akt Apoptosis	Cancer
Ipatasertib (GDC-0068) is an orally active, highly selective and ATP-competitive pan-Akt inhibitor with IC₅₀ values of 5, 18, 8 nM for *Akt1/2/3, respectively. Ipatasertib synchronously activates FoxO3a and NF-κB through inhibition of Akt* leading to p53-independent activation of PUMA. Ipatasertib also induces apoptosis in cancer cells and inhibits tumor growth in xenograft mouse models ^[1] .

HY-10355

AKT inhibitor VIII 55+ Cited Publications Akti-1/2	Akt Apoptosis	Metabolic Disease Cancer
AKT inhibitor VIII (AKTi-1/2) is a cell-permeable quinoxaline compound that has been shown to potently, selectively, allosterically, and reversibly inhibit *Akt1, Akt2, and Akt3* activity with IC₅₀s of 58 nM, 210 nM, and 2119 nM, respectively.

HY-15965

Uprosertib 15+ Cited Publications GSK2141795	Akt	Cancer
Uprosertib (GSK2141795) is a potent and selective *pan-Akt* inhibitor with IC₅₀ values of 180/328/38 nM for Akt1/Akt2/Akt3, respectively.

HY-15727

Afuresertib 15+ Cited Publications GSK2110183; LAE002	Akt PKC ROCK	Cancer
Afuresertib (GSK2110183) is an orally bioavailable, selective, ATP-competitive and potent pan-Akt kinase inhibitor with K_is of 0.08/2/2.6 nM for Akt1/Akt2/Akt3, respectively ^[1] .

HY-100018

BAY1125976 3 Publications Verification	Akt	Cancer
BAY1125976, a chemical probe, is a selective allosteric *Akt1/Akt2* inhibitor; inhibits Akt1 and Akt2 activity with IC₅₀ values of 5.2 nM and 18 nM at 10 μM ATP, respectively.

HY-19719

Miransertib 15+ Cited Publications ARQ-092	Akt Parasite	Infection Cancer
Miransertib (ARQ-092) is a potent, orally active, selective and allosteric *Akt* inhibitor with IC₅₀s of 2.7 nM, 14 nM and 8.1 nM for *Akt1, Akt2, Akt3, respectively. Miransertib is also a potent the AKT1-E17K* mutant protein inhibitor and has the potential for PI3K/AKT-driven tumors and Proteus syndrome research ^[1]. Miransertib is effective against *Leishmania* .

HY-10249

GSK-690693 40+ Cited Publications	Akt AMPK Autophagy	Cancer
GSK-690693 is an ATP-competitive *pan-Akt* inhibitor with IC₅₀s of 2 nM, 13 nM, 9 nM for *Akt1, Akt2* and *Akt3, respectively. GSK-690693 is also an AMPK* inhibitor, affects Unc-51-like autophagy activating kinase 1 (ULK1) activity and robustly inhibits STING-dependent IRF3 activation ^[1] .

HY-133120

INY-03-041 1 Publications Verification	PROTACs Akt	Cancer
INY-03-041 is a potent, highly selective and PROTAC-based pan-AKT degrader consisting of the ATP-competitive *AKT* inhibitor Ipatasertib (HY-15186) conjugated to Lenalidomide (HY-A0003, Cereblon ligand). INY-03-041 inhibits *AKT1, AKT2* and *AKT3* with IC₅₀s of 2.0, 6.8 and 3.5 nM, respectively ^[1].

HY-16071

AT13148 2 Publications Verification	Akt PKA ROCK Ribosomal S6 Kinase (RSK)	Cancer
AT13148 is an orally active and ATP-competitive, multi-AGC kinase inhibitor with IC₅₀s of 38 nM/402 nM/50 nM, 8 nM, 3 nM, and 6 nM/4 nM for Akt1/2/3, p70S6K, PKA, and ROCKI/II, respectively.

HY-176299

Tanerasertib	Akt	Cancer
Tanerasertib (Compound 456) is an *AKT1* inhibitor, targerting to AKT1 ^E17K with the EC₅₀ of 15-60 nM. Tanerasertib can be used in the study of cancer ^[1].

HY-10425

Rizavasertib 10+ Cited Publications A-443654	Akt	Cancer
A-443654 is a *pan-Akt* inhibitor and has equal potency against *Akt1, Akt2, or Akt3* within cells (K_i=160 pM) ^[1].

HY-13254A

A-674563 hydrochloride 5 Publications Verification	Akt	Cancer
A-674563 hydrochloride is a potent and selective *Akt1* inhibitor with K_i of 11 nM.

HY-18271

CaMKII-IN-1 5 Publications Verification	CaMK	Neurological Disease
CaMKII-IN-1 is a highly selective inhibitor of CaMKII with an IC50 value of 63nM. It has almost no effect on CaMKIV, MLCK, p38a, Akt1, and PKC.

HY-151504

Engasertib 2 Publications Verification ALM301	Akt	Cancer
Engasertib is an orally active highly specific *AKT* inhibitor with IC₅₀ values of 0.13 µM, 0.09 µM and 2.75 µM for AKT1, AKT2 and AKT3, respectively. Engasertib inhibits AKT phosphorylation and modulates downstream signalling in vitro. Engasertib can inhibit cancer cell proliferation and tumor growth ^[1].

HY-100501

M2698 1 Publications Verification MSC2363318A	Ribosomal S6 Kinase (RSK) Akt	Cancer
M2698 (MSC2363318A) is an orally active, ATP competitive, selective p70S6K and *Akt* dual-inhibitor with IC₅₀s of 1 nM for p70S6K, Akt1 and Akt3. M2698 can cross the blood-brain barrier and has anti-cancer activity ^[1].

HY-19934

Pifusertib TAS-117	Akt Apoptosis Autophagy	Cancer
Pifusertib (TAS-117) is a potent, selective, orally active allosteric *Akt* inhibitor (with IC₅₀s of 4.8, 1.6, and 44 nM for Akt1, 2, and 3, respectively). Pifusertib triggers anti-myeloma activities and enhances fatal endoplasmic reticulum (ER) stress induced by proteasome inhibition. Pifusertib induces apoptosis and autophagy ^[1].

HY-123037

Triadimefon	Environmental Pollutants AMPK Akt PERK Fungal	Infection Neurological Disease Metabolic Disease Endocrinology
Triadimefon is an orally active fungicide. Triadimefon significantly reduces the phosphorylation of *AKT1* and *ERK1/2. Triadimefon significantly increases pAMPK* levels, but does not affect total AMPK levels. Triadimefon inhibits the growth of Saccharomyces cerevisiae, disrupts hormone homeostasis (affecting the synthesis of testosterone, etc.), inhibits fetal adrenal development in rats, induces metabolic shifts in hepatocytes, and impairs spatial learning and memory ^[1] .

HY-137458A

Vevorisertib trihydrochloride 1 Publications Verification ARQ 751 trihydrochloride	Akt	Cancer
Vevorisertib (ARQ 751) trihydrochloride is a selective, allosteric, pan-AKT and AKT1-E17K mutant inhibitors. Vevorisertib trihydrochloride potently inhibit phosphorylation of AKT. Vevorisertib trihydrochloride has Kd values of 1.2 nM and 8.6 nM for AKT1 and AKT1-E17K, respectively. Vevorisertib trihydrochloride has IC₅₀ values of 0.55, 0.81, and 1.3 nM for AKT1, AKT2, and AKT3, respectively. Vevorisertib trihydrochloride can be used for the research of cancer ^[1].

HY-13254

A-674563 5 Publications Verification	Akt	Cancer
A-674563 is an orally active *Akt1* inhibitor with a K_i of 11 nM.

HY-19719A

Miransertib hydrochloride 15+ Cited Publications ARQ-092 hydrochloride	Akt Parasite	Infection Cancer
Miransertib hydrochloride (ARQ-092 hydrochloride) is a potent, orally active, selective and allosteric *Akt* inhibitor with IC₅₀s of 2.7 nM, 14 nM and 8.1 nM for *Akt1, Akt2, Akt3, respectively. Miransertib hydrochloride is also a potent the AKT1-E17K* mutant protein inhibitor and has the potential for PI3K/AKT-driven tumors and Proteus syndrome research ^[1]. Miransertib hydrochloride is effective against *Leishmania* .

HY-15727A

Afuresertib hydrochloride 15+ Cited Publications GSK2110183 hydrochloride; LAE002 hydrochloride	Akt PKC ROCK	Cancer
Afuresertib hydrochloride (GSK 2110183 hydrochloride) is an orally bioavailable, selective, ATP-competitive and potent pan-Akt kinase inhibitor with K_is of 0.08/2/2.6 nM for Akt1/Akt2/Akt3 respectively ^[1] .

HY-15186A

Ipatasertib dihydrochloride 55+ Cited Publications GDC-0068 dihydrochloride; RG-7440 dihydrochloride	Organoid Akt	Cancer
Ipatasertib dihydrochloride (GDC-0068 dihydrochloride) is a highly selective and ATP-competitive *pan-Akt* inhibitor with IC₅₀s of 5, 18 and 8 nM for *Akt1, Akt2* and *Akt3*, respectively.

HY-12059

AT7867 5 Publications Verification	Akt PKA Ribosomal S6 Kinase (RSK)	Cancer
AT7867 is a potent ATP-competitive inhibitor of *Akt1/Akt2/Akt3* and p70S6K/PKA with IC₅₀s of 32 nM/17 nM/47 nM and 85 nM/20 nM, respectively.

HY-132302

Hu7691	Akt PKA PKC ROCK Ribosomal S6 Kinase (RSK) SGK	Cancer
Hu7691 is an orally active, selective *Akt* inhibitor with IC₅₀s of 4.0 nM, 97.5 nM, 28 nM for Akt1, Akt2 and Akt3, respectively. Hu7691 inhibits tumor growth and enables decrease of cutaneous toxicity in mice ^[1].

HY-19934A

Pifusertib hydrochloride TAS-117 hydrochloride	Akt Apoptosis Autophagy	Cancer
Pifusertib (TAS-117) hydrochloride is a potent, selective, orally active allosteric *Akt* inhibitor (with IC₅₀s of 4.8, 1.6, and 44 nM for Akt1, 2, and 3, respectively). Pifusertib hydrochloride triggers anti-myeloma activities and enhances fatal endoplasmic reticulum (ER) stress induced by proteasome inhibition. Pifusertib hydrochloride induces apoptosis and autophagy ^[1].

HY-141539

SETDB1-TTD-IN-1 5 Publications Verification	Histone Methyltransferase Akt	Cancer
SETDB1-TTD-IN-1 is a *SETDB1* methyltransferase activator and *SETDB1-TTD* competitive inhibitor (K_d of 88 nM), and selectivity for SETDB1-TTD over other tudor and bromodomain proteins. SETDB1-TTD-IN-1 stimulates methyltransferase activity via increased catalytic activity, promotes *Akt1* Lys64 methylation, Akt1 Thr308 phosphorylation and activation. SETDB1-TTD-IN-1 prevents SETDB1-TTD-histone H3 peptide association, induces global gene expression changes, exhibits cellular target engagement, and acts as a tool compound for SETDB1-TTD function exploration. SETDB1-TTD-IN-1 can be used for the research of breast cancer ^[1] .

HY-W073128

Perfluorotetradecanoic acid PFTeDA	PPAR Apoptosis PGC-1α AMPK Akt mTOR Reactive Oxygen Species (ROS)	Endocrinology
Perfluorotetradecanoic acid (PFTeDA) is an orally active perfluoroalkyl substance. Perfluorotetradecanoic acid directly binds to the ligand-binding domain of purified hPPARγ, with a K_d value of 157.8 μM. Perfluorotetradecanoic acid significantly reduces the activity of the *SIRT1/PGC1α* and AMPK signaling pathways while stimulating the activity of the *AKT1/mTOR* signaling pathway. Perfluorotetradecanoic acid significantly upregulates the expression of corticosterone biosynthesis genes. Perfluorotetradecanoic acid increases ROS levels and promotes Apoptosis. Perfluorotetradecanoic acid impairs Leydig cell function and male reproductive endocrine function in adult male rats ^[1] .

HY-B0960

Sulfabenzamide 1 Publications Verification N-Sulfanilylbenzamide	Bacterial Autophagy MDM-2/p53 Caspase PARP DNA-PK Akt	Infection Cancer
Sulfabenzamide (N-Sulfanilylbenzamide) is a sulfonamide antibacterial agent. Sulfabenzamide exhibit antibacterial activity against Staphylococcus aureus (ATCC 25923) and Escherichia coli (ATCC 8739). Sulfabenzamide can promote autophagic cell autophagy in breast cancer cells through p53/ DRAM pathway. Sulfabenzamide increases caspase-3 activity, deactivates *PARP1* and DNA-PK, downregulates *AKT1* and *AKT2*. Sulfabenzamide can be used for the researches of breast cancer and bacterial infections ^[1] .

HY-137458

Vevorisertib 1 Publications Verification ARQ 751	Akt Ser/Thr Protease	Cancer
Vevorisertib (ARQ 751) is an orally active, potent and selective *pan-AKT* serine/threonine kinase inhibitor against *AKT1* (IC₅₀=0.55 nM), *AKT2* (IC₅₀=0.81 nM), and *AKT3* (IC₅₀=1.31 nM). Vevorisertib, as a single agent or in combination with other anti-cancer agents, can be used for the research of solid tumors with PIK3CA / AKT / PTEN mutations ^[1] .

HY-50862

Akt1/Akt2-IN-1 2 Publications Verification	Akt	Cancer
Akt1/Akt2-IN-1 (Compound 17) is an allosteric inhibitor of *Akt1* (IC₅₀=3.5 nM) and *Akt2* (IC₅₀=42 nM), with potent and balanced activity ^[1].

HY-16666

3CAI 4 Publications Verification	Akt	Cancer
3CAI is a potent and specific *AKT1* and *AKT2* inhibitor.

HY-19982

AKT-IN-6 2 Publications Verification	Akt	Cancer
AKT-IN-6 (Example 13) is a potent Akt inhibitor. AKT-IN-6 inhibits Akt1, Akt2 and Akt3 with IC₅₀s < 500nM, respectively. (patent WO2013056015A1).

HY-N7627

Regaloside C	Estrogen Receptor/ERR Toll-like Receptor (TLR) Akt MMP HSP	Inflammation/Immunology
Regaloside C is an anti-inflammatory agent and antioxidant that scavenges ABTS and DPPH free radicals. *Regaloside C targets multiple molecules including TNF-α, MMP-2, ERα, AKT1, TLR4* and HSP90-α. Regaloside C is applicable to research related to inflammatory diseases ^[1] .

HY-129119

Akt1/Akt2-IN-2	Akt Caspase	Cancer
Akt1/Akt2-IN-2 (compound 7) is an allosteric dual *Akt1* and *Akt2* inhibitor (IC₅₀=138 nM and 212 nM, respectively). Akt1/Akt2-IN-2 increases activity of caspase-3, and inhibits viability of a number of tumor cells ^[1].

HY-151613A

MS15 TFA	PROTACs Akt	Cancer
MS15 TFA is a potent and selective AKT PROTAC degrader. MS15 TFA inhibits the AKT1, -2, and -3 activities, with IC₅₀ values of 798 nM, 90 nM, and 544 nM, respectively ^[1].

HY-145282

MS170 1 Publications Verification	PROTACs Akt	Cancer
MS170 is a potent and selective PROTAC AKT degrader. MS170 depletes cellular total *AKT* (T-AKT) with the DC₅₀ value of 32 nM. MS170 binds to AKT1, AKT2, and AKT3 with K_ds of 1.3 nM, 77 nM, and 6.5 nM, respectively ^[1].

HY-N8122

24-Methylenecycloartanyl ferulate	Akt	Cancer
24-Methylenecycloartanyl ferulate is a γ-oryzanol compound. 24-Methylenecycloartanyl ferulate promotes parvin-beta expression in human breast cancer cells. 24-Methylenecycloartanyl ferulate is a potential ATP-competitive *Akt1* inhibitor (EC₅₀= 33.3μM) ^[1].

HY-163650

DTPD-Q	Akt	Endocrinology
DTPD-Q is an antioxidant and an oxidative derivative of methylbenzenesulfonyl-p-phenylenediamine DTPD. DTPD-Q is a molecule that binds to *AKT1* and *ESR1*, with high binding affinity to core targets associated with male infertility and its subtypes. DTPD-Q can be used in studies related to male infertility ^[1] .

HY-133120A

INY-03-041 trihydrochloride 1 Publications Verification	PROTACs Akt	Cancer
INY-03-041 trihydrochloride is a potent, highly selective and PROTAC-based pan-AKT degrader consisting of the ATP-competitive *AKT* inhibitor Ipatasertib (HY-15186) conjugated to Lenalidomide (HY-A0003). INY-03-041 trihydrochloride inhibits *AKT1, AKT2* and *AKT3* with IC₅₀s of 2.0, 6.8 and 3.5 nM, respectively ^[1].

HY-119016

SK1-I 1 Publications Verification BML-258	SphK CaMK	Cancer
SK1-I (BML-258), an analog of sphingosine, is an isozyme-specific competitive *SPHK1* inhibitor with a K_i value of 10 μM ^[1]. SK1-I shows no activity at SPHK1 PKCα, PKCδ, PKA, AKT1, ERK1, EGFR, CDK2, IKKβ or CamK2β. SK1-I enhances autophagy and has antitumor activity .

HY-173155

AKT1-IN-9	Akt	Cancer
AKT1-IN-9 (4) is a selective mutant *AKT1(E17K)* inhibitor, with EC₅₀ values of 9 nM and 995 nM in LAPC4-CR and SkBr3 cells, respectively ^[1].

HY-151613

MS15	PROTACs Akt	Cancer
MS15 is a potent and selective AKT PROTAC degrader. MS15 inhibits the AKT1, -2, and -3 activities, with IC₅₀ values of 798 nM, 90 nM, and 544 nM, respectively ^[1].

HY-N10336

Notoginsenoside R4	VEGFR STAT Akt Ras	Others
Notoginsenoside R4 is a ginsenoside that can be isolated from ginseng roots. In the molecular docking results, Notoginsenoside R4 can target STAT3, AKT1, HRAS, VEGFA and CASP3 ^[1] .

HY-12059A

AT7867 dihydrochloride 5 Publications Verification	Akt PKA Ribosomal S6 Kinase (RSK)	Cancer
AT7867 dihydrochloride is a potent ATP-competitive inhibitor of *Akt1/Akt2/Akt3* and p70S6K/PKA with IC₅₀s of 32 nM/17 nM/47 nM and 85 nM/20 nM, respectively.

HY-W013816

Dipentyl phthalate	AMPK Akt	Metabolic Disease
Dipentyl phthalate is an endocrine-disrupting phthalate plasticizer. Dipentyl phthalate increases AMPK phosphorylation and decreases AKT1 phosphorylation and SIRT1 levels. Dipentyl phthalate reduces adrenocorticotropic hormone levels. Dipentyl phthalate is a testicular toxicant ^[1].

HY-163579

Akt1-IN-7	Akt	Cancer
Akt1-IN-7 (Compound 370) is an *Akt1* inhibitor (IC₅₀: <15 nM) ^[1].

HY-RS00542

AKT1 Human Pre-designed siRNA Set A	Small Interfering RNA (siRNA) Akt	Others
AKT1 Human Pre-designed siRNA Set A contains three designed siRNAs for AKT1 gene (Human), as well as a negative control, a positive control, and a FAM-labeled negative control.

AKT1 Human Pre-designed siRNA Set A AKT1 Human Pre-designed siRNA Set A

HY-16461

Solenopsin (-)-Solenopsin A	Akt Ribosomal S6 Kinase (RSK) PI3K PDK-1 FOXO Mitophagy Reactive Oxygen Species (ROS) Mitochondrial Metabolism	Cardiovascular Disease
Solenopsin ((-)-Solenopsin A) is an ATP-competitive and selective *Akt-1* inhibitor with an IC₅₀ of 5-10 μM, and also acts as an *RSK1* inhibitor. Solenopsin inhibits the activities of *PDK1* in lipid rafts, downregulates PI3K, blocks PI3K-dependent generation of 3-phosphoinositides, and suppresses the phosphorylation of *FOXO1a. Solenopsin induces Mitophagy* and ROS production, reduces mitochondrial oxygen consumption, and exhibits antiproliferative and antiangiogenic activities. Solenopsin can be used in research related to hyperproliferative skin diseases and malignant diseases ^[1] .

Cat. No.	Product Name

HY-L015

PI3K/Akt/mTOR Compound Library

1,049 compounds

The PI3K/Akt/mTOR pathway controls many cellular processes that are important for the formation and progression of cancer, including apoptosis, transcription, translation, metabolism, angiogenesis, and cell cycle progression. Every major node of this signaling network is activated in a wide range of human tumors. Mechanisms for the pathway activation include activation of receptor tyrosine kinases (RTKs) upstream of PI3K, mutation or amplification of PIK3CA encoding p110α catalytic subunit of PI3K, mutation or loss of PTEN tumor suppressor gene, and mutation or amplification of Akt1. Once the pathway is activated, signaling through Akt can stimulate a series of substrates including mTOR which is involved in protein synthesis. Thus, inhibition of this pathway is an attractive concept for cancer prevention and/or therapy. Currently some mTOR inhibitors are approved for several indications, and there are several novel PI3K/Akt/mTOR inhibitors in clinical trials.

MCE owns a unique collection of 1,049 compounds that can be used for PI3K/Akt/mTOR pathway research. PI3K/Akt/mTOR Compound Library also acts as a useful tool for anti-cancer drug discovery.

Cat. No.	Product Name	Target	Research Area

HY-P5910

Azurin p28 peptide	MDM-2/p53 Apoptosis	Cancer
Azurin p28 peptide is a tumor-penetrated antitumor peptide. Azurin p28 peptide redues proteasomal degradation of p53 through formation of a p28: p53 complex. Azurin p28 peptide induces apoptosis or cell cycle arrest. Azurin p28 peptide inhibits p53-positive tumor growths. Azurin p28 peptide shows antiangiogenic effect by inhibiting phosphorylation of VEGFR-2, FAK and Akt .

HY-P5910A

Azurin p28 peptide TFA	MDM-2/p53 Apoptosis	Cancer
Azurin p28 peptide TFA is a tumor-penetrated antitumor peptide. Azurin p28 peptide TFA redues proteasomal degradation of p53 through formation of a p28: p53 complex. Azurin p28 peptide TFA induces apoptosis or cell cycle arrest. Azurin p28 peptide TFA inhibits p53-positive tumor growths. Azurin p28 peptide TFA shows antiangiogenic effect by inhibiting phosphorylation of VEGFR-2, FAK and Akt .

HY-P10064

Akt Substrate	Peptides	Others
Akt Substrate (Akt/SKG substrate) is a 7 amino acid synthetic peptide suitable as a substrate for *Akt* .

Cat. No.	Product Name	Category	Target	Chemical Structure

HY-N0004

Oridonin Maximum Cited Publications 26 Publications Verification NSC-250682; Isodonol	Infection Structural Classification Classification of Application Fields Terpenoids Labiatae Diterpenoids Plants Inflammation/Immunology Disease Research Fields Butea monosperma Kuntze	Akt Bacterial Ligands for E3 Ligase
Oridonin (NSC-250682), a diterpenoid isolated from Rabdosia rubescens, acts as an inhibitor of *AKT, with IC₅₀s of 8.4 and 8.9 μM for AKT1* and AKT2; Oridonin possesses anti-tumor, anti-bacterial and anti-inflammatory effects.

HY-107738

Guggulsterone 20+ Cited Publications Z/E-Guggulsterone	Triterpenes Structural Classification Classification of Application Fields Terpenoids Plants Burseraceae Disease Research Fields Commiphora wightii Cancer	Apoptosis JNK Akt Caspase FXR Autophagy
Guggulsterone is a plant sterol derived from the gum resin of the tree Commiphora wightii. Guggulsterone inhibits the growth of a wide variety of tumor cells and induces apoptosis through down regulation of antiapoptotic gene products (IAP1, *xIAP, Bfl-1/A1, Bcl-2, cFLIP and survivin), modulation of cell cycle proteins (cyclin D1 and c-Myc), activation of caspases and JNK, inhibition of Akt* . Guggulsterone, a farnesoid X receptor (FXR) antagonist, with IC₅₀s of 24.06 μM and 39.05 μM for (-)-(E)-Guggulsterone (HY-N7781) and (Z)-Guggulsterone (HY-110066), respectively .

HY-N7922

Urolithin M5 1 Publications Verification Decarboxyellagic acid	Structural Classification Canarium album (Lour.) Rauesch. Phenols Polyphenols Plants Burseraceae Source Classification	Influenza Virus p38 MAPK EGFR Akt Reactive Oxygen Species (ROS) Apoptosis
Urolithin M5 (Decarboxyellagic acid) is an orally active influenza virus neuraminidase inhibitor and neuroprotective agent, with IC₅₀ values of 174.8 μM (HK68), 191.5 μM (pdm09), 243.2 μM (WSN) and 257.1 μM (PR8) against four influenza virus neuraminidases, respectively. Urolithin M5 inhibits viral neuraminidase activity, thereby blocking influenza virus replication (including oseltamivir (HY-13317)-resistant strains), protecting infected mammals from death and improving pulmonary edema. Urolithin M5 forms a hydrogen-bond stabilized complex with *IGF1R, and binds to MAPK14, AKT1, NFKB1* and EGFR. Urolithin M5 reduces reactive oxygen species production, inhibits neuronal apoptosis, restores mitochondrial transmembrane potential, and promotes neurite outgrowth of damaged neuronal cells. Urolithin M5 can be used in research related to influenza virus infection and Alzheimer's disease ^[1] .

HY-N0863

Methyl protodioscin NSC-698790; Smilax saponin B	Structural Classification other families Classification of Application Fields Plants Disease Research Fields Steroids Source Classification Cancer	Bcl-2 Family Apoptosis Akt c-Myc ERK p38 MAPK JNK FOXO
Methyl protodioscin (NSC-698790; Smilax saponin B) is a multi-target, selective, steroidal diglycoside inhibitor with antitumor activity that induces cell cycle arrest. The mechanism of action of Methyl protodioscin is complex, involving the induction of G2/M cell cycle arrest, regulation of the Bcl-2/Bax apoptotic pathway, inhibition of the *Akt1/c-Myc* axis and MAPK/ERK signaling, while simultaneously downregulating ADAM15 and inducing *FOXO1* to reduce cholesterol synthesis. It also inhibits the JNK/c-Jun pathway, reducing the production of inflammatory factors (IL-6, TNF-α). Methyl protodioscin exhibits significant antitumor (inhibiting proliferation, migration, invasion, and inducing apoptosis), anti-inflammatory, and anti-restenosis activities. Methyl protodioscin can be used in research on lung cancer, prostate cancer, pancreatic cancer, and other tumors, as well as inflammatory diseases such as airway inflammation and enteritis ^[1] .

HY-N2484

Methylnissolin 2 Publications Verification Astrapterocarpan	Cardiovascular Disease Structural Classification Monophenols Flavonoids Classification of Application Fields Leguminosae Phenols Astragalus membranaceus var. mongholicus (Bunge)P.K.Hsiao Plants Other Flavonoids Disease Research Fields Source Classification	PDGFR ERK
Methylnissolin (Astrapterocarpan) is an osteoclast inhibitor with anti-inflammatory, neuroprotective and antioxidant activities. Methylnissolin downregulates the activation of the MAPK and *PI3K/AKT* pathways, inhibits the phosphorylation of *MAPK1* and *AKT1, and blocks PDGF-BB-induced phosphorylation of ERK1/2. Methylnissolin reduces the expression and secretion of proinflammatory mediators, decreases intracellular ROS* levels, upregulates antioxidant enzymes, and downregulates osteoclastogenesis markers. Methylnissolin is applicable to research related to ischemic stroke, osteoporosis, cardiovascular diseases, skin aging, etc. ^[1]

HY-N1401

20(R)-Ginsenoside Rh2 2 Publications Verification	Panax ginseng C. A. Meyer Infection Triterpenes Human Gut Microbiota Metabolites Classification of Application Fields Terpenoids Plants Endogenous metabolite Inflammation/Immunology Disease Research Fields Araliaceae Source Classification	MMP Apoptosis HSV DNA/RNA Synthesis NO Synthase Prostaglandin Receptor Reactive Oxygen Species (ROS) Akt
20(R)-Ginsenoside Rh2 is an orally active protopanaxadiol-type saponin with multiple biological activities. 20(R)-Ginsenoside Rh2 exerts a significant inhibitory effect on non-small cell lung cancer and liver cancer by inducing cell cycle arrest and promoting apoptosis. 20(R)-Ginsenoside Rh2 exerts anti-γ-herpesvirus effects by inhibiting viral DNA replication. 20(R)-Ginsenoside Rh2 inhibits inflammatory mediators by reducing the levels of NO, PGE2, and ROS; it can delay skin photoaging by reducing ROS and inhibiting MMP-9/2 activity. 20(R)-Ginsenoside Rh2 accelerates the recovery after muscle injury by activating the *Akt1/PKB* signaling pathway. 20(R)-Ginsenoside Rh2 can inhibit osteoclast formation and exert an anti-osteoporosis effect ^[1] .

HY-N7627

Regaloside C	Cardiovascular Disease Structural Classification Classification of Application Fields Simple Phenylpropanols Gramineae Secale cereale Phenols Polyphenols Phenylpropanoids Plants Disease Research Fields Source Classification	Estrogen Receptor/ERR Toll-like Receptor (TLR) Akt MMP HSP
Regaloside C is an anti-inflammatory agent and antioxidant that scavenges ABTS and DPPH free radicals. *Regaloside C targets multiple molecules including TNF-α, MMP-2, ERα, AKT1, TLR4* and HSP90-α. Regaloside C is applicable to research related to inflammatory diseases ^[1] .

HY-N13250

Hawthorn Extract	Cardiovascular Disease Classification of Application Fields Rosaceae Plants Disease Research Fields Source Classification	Apoptosis AMPK Elastase Bcl-2 Family Interleukin Related Caspase PI3K Akt SOD
Hawthorn Extract is an orally active hawthorn extract. Hawthorn Extract decreases Bax expression and increases Bcl-2 expression in the aorta. Hawthorn Extract regulates the AMPK signaling pathway, induces apoptosis, enhances the hepatic antioxidant system, and ameliorates symptoms of liver injury, inflammation and cancer. Hawthorn Extract reduces plasma levels of pro-inflammatory factors, increases plasma levels of anti-inflammatory adiponectin, and alleviates atherosclerotic plaque lesions in the aorta. Hawthorn Extract improves symptoms associated with chronic heart failure . Hawthorn Extract inhibits FMLP-induced superoxide anion production, Elastase release, ILB₄ generation and calcium signaling in neutrophils, and also reduces LPS-induced cytokine production in neutrophils. Hawthorn Extract induces autophagy and inhibits the proliferation of intestinal stem cells. Hawthorn Extract can be used in research related to atherosclerosis, hepatitis, alcoholic liver disease, non-alcoholic fatty liver disease, hepatocellular carcinoma, chronic heart failure and hypotension ^[1] .

HY-N2902

Artocarpin	Structural Classification Flavonols Flavonoids Plants Moraceae Source Classification	Reactive Oxygen Species (ROS)
Artocarpin is an orally active apoptosis inducer. Artocarpin targets NF-κB, *Erk1/2, p38 MAPK, AktS473, p53, Akt 1* kinase and Akt 2 kinase. Artocarpin induces reactive oxygen species (ROS) production, mediates p53-dependent and p53-independent apoptotic signaling pathways, induces G1-phase cell cycle arrest, and triggers autophagic cell death. Artocarpin exerts cytotoxic and bactericidal effects on cancer cells, reduces bacterial load, and exhibits anti-inflammatory, analgesic and anti-angiogenic activities ^[1] .

HY-N8122

24-Methylenecycloartanyl ferulate	Triterpenes Monophenols other families Classification of Application Fields Terpenoids Phenols Plants Disease Research Fields Source Classification Cancer	Akt
24-Methylenecycloartanyl ferulate is a γ-oryzanol compound. 24-Methylenecycloartanyl ferulate promotes parvin-beta expression in human breast cancer cells. 24-Methylenecycloartanyl ferulate is a potential ATP-competitive *Akt1* inhibitor (EC₅₀= 33.3μM) ^[1].

HY-N10336

Notoginsenoside R4	Panax ginseng C. A. Meyer Triterpenes Terpenoids Plants Araliaceae Source Classification	VEGFR STAT Akt Ras
Notoginsenoside R4 is a ginsenoside that can be isolated from ginseng roots. In the molecular docking results, Notoginsenoside R4 can target STAT3, AKT1, HRAS, VEGFA and CASP3 ^[1] .

HY-122949

Momordicine I 2 Publications Verification	Triterpenes Terpenoids Cucurbitaceae Plants Momordica charantia Linn. Source Classification	Apoptosis Autophagy DGK Mitochondrial Metabolism NO Synthase PI3K Akt Interleukin Related Src AMPK mTOR NF-κB c-Met/HGFR STAT Keap1-Nrf2 Reactive Oxygen Species (ROS) Oxidative Phosphorylation Endogenous Metabolite
Momordicine I is a cucurbitane-type triterpenoids. Momordicine I suppresses glioma growth by promoting apoptosis and impairing mitochondrial oxidative phosphorylation. Momordicine I inhibits glycolysis, lipid metabolism, induces autophagy in HNC cells to suppress head and neck cancer growth. Momordicine I alleviates isoproterenol-induced cardiomyocyte hypertrophy through suppression of PLA2G6 and DGK-ζ. Momordicine I exerts its cardiovascular benefits by upregulating nitric oxide, inhibiting the activity of angiotensin-converting enzyme (ACE), activating the *PI3K/Akt* pathway, reducing oxidative stress and inflammation. Momordicine I inhibits *AKT1, IL-6, and SRC*, suggesting its potential application in type 2 diabetes ^[1] .

HY-N0004R

Oridonin (Standard) NSC-250682 (Standard); Isodonol (Standard)	Structural Classification Terpenoids Labiatae Diterpenoids Plants Butea monosperma Kuntze	Reference Standards Akt Bacterial
Oridonin (Standard) is the analytical standard of Oridonin. This product is intended for research and analytical applications. Oridonin (NSC-250682), a diterpenoid isolated from Rabdosia rubescens, acts as an inhibitor of AKT, with IC50s of 8.4 and 8.9 μM for AKT1 and AKT2; Oridonin possesses anti-tumor, anti-bacterial and anti-inflammatory effects.

HY-N1435R

Oroxin B (Standard)	Structural Classification Flavonoids Flavones Phenols Polyphenols Bignoniaceae Plants Oroxylum indicum (Linn.) Bentham ex Kurz Source Classification	Reference Standards Apoptosis PI3K PTEN Autophagy
Oroxin B (Standard) is the analytical standard of Oroxin B. This product is intended for research and analytical applications. Oroxin B (OB) is a flavonoid isolated from traditional Chinese herbal medicine Oroxylum indicum (L.) Vent. Oroxin B (OB) possesses obvious inhibitory effect and induces early apoptosis rather than late apoptosis on liver cancer cells through upregulation of PTEN, down regulation of COX-2, VEGF, PI3K, and p-AKT . Oroxin B (OB) selectively induces tumor-suppressive ER stress in malignant lymphoma cells .

HY-W750451

Reptoside	Iridoids Terpenoids Labiatae Plants Source Classification Carphephorus corymbosus (Nutt.) Torr. & A.Gray	Akt
Reptoside, an iridoid glucoside, is a DNA damaging active agent. Reptoside has strong interactions with Trp352 and Tyr335 in *AKT1* ^[1].

HY-N1401R

20(R)-Ginsenoside Rh2 (Standard)	Panax ginseng C. A. Meyer Triterpenes Structural Classification Human Gut Microbiota Metabolites Terpenoids Plants Endogenous metabolite Araliaceae Source Classification	Reference Standards MMP Apoptosis HSV
20(R)-Ginsenoside Rh2 (Standard) is the analytical standard of 20(R)-Ginsenoside Rh2. This product is intended for research and analytical applications. 20(R)-Ginsenoside Rh2 is an orally active protopanaxadiol-type saponin with multiple biological activities. 20(R)-Ginsenoside Rh2 exerts a significant inhibitory effect on non-small cell lung cancer and liver cancer by inducing cell cycle arrest and promoting apoptosis. 20(R)-Ginsenoside Rh2 exerts anti-γ-herpesvirus effects by inhibiting viral DNA replication. 20(R)-Ginsenoside Rh2 inhibits inflammatory mediators by reducing the levels of NO, PGE2, and ROS; it can delay skin photoaging by reducing ROS and inhibiting MMP-9/2 activity. 20(R)-Ginsenoside Rh2 accelerates the recovery after muscle injury by activating the *Akt1/PKB* signaling pathway. 20(R)-Ginsenoside Rh2 can inhibit osteoclast formation and exert an anti-osteoporosis effect.

HY-N17458

N-Acetyldehydroanonaine	Structural Classification Alkaloids Other Alkaloids Rutaceae Plants Zanthoxylum simulans Hance Source Classification	Akt p38 MAPK
N-Acetyldehydroanonaine is an alkaloid that acts as a ligand for *AKT1* and *MAPK1. N-Acetyldehydroanonaine can be isolated from plants of the Zanthoxylum* genus. N-Acetyldehydroanonaine is applicable to the research of diseases such as gastric cancer ^[1] .

HY-N17632

Moracin G	Structural Classification Phenols Polyphenols Plants Moraceae Morus alba Linn. Source Classification	Estrogen Receptor/ERR Akt MELK COX Apoptosis
Moracin G is a plant-derived kinase modulator and receptor ligand that forms stable bindings with multiple key proteins (AKT1, COX2 and Estrogen receptor 1) and competitively inhibits the activity of specific kinases. By binding to MELK to disrupt cell cycle regulation, Moracin G impairs the survival and proliferation of cancer cells, induces cancer cell apoptosis, and thereby exerts anti-tumor potential. Moracin G can be used in research related to periodontitis and breast cancer ^[1] .

Recombinant Proteins Recommended:

AKT Serine/Threonine Kinase 1 (AKT1)

Species:	Human (3)
Tag:	His (1) GST (3)
Source:	sf9 insect cells (1) Sf9 insect cells (2)

Cat. No.	Compare	Product Name	Species	Source	Image

HY-P704088

	AKT1 Protein, Human (Active, S473D, sf9, His, GST) RAC-alpha serine/threonine-protein kinase; PKB; RAC-PK-alpha; Akt1; RAC	Human	Sf9 insect cells
	The AKT1 protein is part of the AKT kinase family and is critical for metabolism, proliferation, survival, growth, and angiogenesis. It phosphorylates more than 100 substrates, coordinates insulin-induced SLC2A4/GLUT4 translocation, affects glucose uptake, and controls glycogen storage through inhibition of GSK3A/B. AKT1 Protein, Human (S473D, sf9, His, GST) is the recombinant human-derived AKT1 protein, expressed by Sf9 insect cells, with N-His and N-GST labeled tag.

HY-P702631

	AKT1 Protein, Human (Active, sf9, GST) 1 Publications Verification Akt1; v-Akt murine thymoma viral oncogene homolog 1; RAC-alpha serine/threonine-protein kinase; Akt; PKB; PRKBA; RAC; PKB alpha; RAC-PK-alpha; proto-oncogene c-Akt; protein kinase B alpha; rac protein kinase alpha; PKB-ALPHA; RAC-ALPHA; MGC99656	Human	Sf9 insect cells
	The AKT1 protein is part of the AKT kinase family and is critical for metabolism, proliferation, survival, growth, and angiogenesis. It phosphorylates more than 100 substrates, coordinates insulin-induced SLC2A4/GLUT4 translocation, affects glucose uptake, and controls glycogen storage through inhibition of GSK3A/B. AKT1 Protein, Human (Active, sf9, GST) is the recombinant human-derived AKT1, expressed by Sf9 insect cells, with GST labeled tag. The total length of AKT1 Protein, Human (Active, sf9, GST) is 480 a.a..

HY-P705727

	AKT1 Protein, Human (Active, E17K, sf9, GST) Akt1; v-Akt murine thymoma viral oncogene homolog 1; RAC-alpha serine/threonine-protein kinase; Akt; PKB; PRKBA; RAC; PKB alpha; RAC-PK-alpha; proto-oncogene c-Akt; protein kinase B alpha; rac protein kinase alpha; PKB-ALPHA; RAC-ALPHA; MGC99656	Human	sf9 insect cells

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Cat. No.	Product Name	Chemical Structure

HY-B0960S

Sulfabenzamide-d4

Sulfabenzamide (N-Sulfanilylbenzamide)-d₄ is the deuterium labeled Sulfabenzamide (HY-B0960). Sulfabenzamide is a sulfonamide antibacterial agent. Sulfabenzamide exhibit antibacterial activity against Staphylococcus aureus (ATCC 25923) and Escherichia coli (ATCC 8739). Sulfabenzamide can promote autophagic cell autophagy in breast cancer cells through p53/ DRAM pathway. Sulfabenzamide increases caspase-3 activity, deactivates PARP1 and DNA-PK, downregulates AKT1 and AKT2. Sulfabenzamide can be used for the researches of breast cancer and bacterial infections ^[1] .

Host:	Mouse (9) Rabbit (17)
Reactivity:	Transfected (1) Human (25) Bovine (1) Rat (21) Mouse (20) Monkey (4) Chicken (1) Dog (1) Hamster (2) Pig (1)
Application:	IHC-P (15) ICC/IF (16) IF-Tissue (1) IP (12) WB (25) IHC-F (3) FC (8) ELISA (9)
Isotype:	IgG3,IgG/Kappa (1) IgG (16) IgG1 (4) IgG/Kappa (1) IgG2b (1)
Conjugation:	Non-conjugated (26)
Clonality:	Polyclonal (1) Monoclonal (16) Recombinant (6)
Modification:	Phosphorylated (5) Unmodified (12)

Cat. No.	Compare	Product Name	Application	Reactivity	Image

HY-P80008

	AKT1 Antibody (YA634) Akt 1; Akt; Akt1; Akt1_HUMAN ; MGC99656; PKB; PKB-ALPHA; PRKBA; Protein Kinase B Alpha ; Proto-oncogene c-Akt; RAC Alpha;	IHC-P, IHC-F, ICC/IF, IP, FC	Human, Mouse
	AKT1 Antibody (YA634) is a Rabbit-derived and non-conjugated IgG monoclonal antibody, targeting to AKT1.

HY-P85759

	AKT Antibody (YA5451) Akt1	WB, IP, ICC/IF, ELISA	Human, Mouse, Rat
	AKT Antibody (YA5451) is a Mouse-derived and non-conjugated IgG3 monoclonal antibody, targeting to AKT.

HY-P86067

	*Phospho-AKT(S473) Antibody (YA5759)* Akt1	WB, IHC-P, ICC/IF	Human
	Phospho-AKT(S473) Antibody (YA5759) is a Mouse-derived and non-conjugated monoclonal antibody, targeting to Phospho-AKT(S473).

HY-P85561

	AKT1 Antibody (YA5253) Akt 1; Akt; Akt1; Akt1_HUMAN; C Akt; MGC99656; PKB; PKB-ALPHA; PRKBA; Protein Kinase B Alpha; Protein kinase B; Proto-oncogene c-Akt; RAC Alpha; RAC; RAC PK Alpha; RAC Serine/Threonine Protein Kinase; RAC-alpha serine/threonine-protein kinase; RAC-PK-alpha; vAkt Murine Thymoma Viral Oncogene Homolog 1	WB	Mouse, Transfected
	AKT1 Antibody (YA5253) is a Mouse-derived and non-conjugated monoclonal antibody, targeting to AKT1.

HY-P85416

	AKT1 Antibody (YA5108) Akt1; PKB; RAC; RAC-alpha serine/threonine-protein kinase; Protein kinase B; PKB; Protein kinase B alpha; PKB alpha; Proto-oncogene c-Akt; RAC-PK-alpha	WB	Human, Mouse, Rat, Bovine, Chicken, Pig
	AKT1 Antibody (YA5108) is a Mouse-derived and non-conjugated monoclonal antibody, targeting to AKT1.

HY-P80276

	*Phospho-AKT1(Ser473) Antibody (YA227)* 4 Publications Verification Akt 1 antibody; Akt antibody; Akt1 antibody; Akt1_HUMAN antibody; MGC99656 antibody; PKB antibody; PKB-ALPHA antibody; PRKBA antibody; Protein Kinase B Alpha antibody; Protein kinase B antibody; Proto-oncogene c-Akt antibody; RAC Alpha antibody; RAC antibody; RAC-alpha serine/threonine-protein kinase antibody; RAC-PK-alpha antibody;	WB, ICC/IF, IHC-P	Human, Mouse, Rat, Dog
	Phospho-AKT1(Ser473) Antibody (YA227) is a Rabbit-derived and non-conjugated IgG monoclonal antibody, targeting to Phospho-AKT1(Ser473).

HY-P80007

	AKT1 Antibody (YA834) 1 Publications Verification	WB, IHC-P, ICC/IF	Human
	AKT1 Antibody (YA834) is a Mouse-derived and non-conjugated IgG2b monoclonal antibody, targeting to AKT1.

HY-P80009

	AKT1/2/3 Antibody (YA633) 1 Publications Verification	WB, ICC/IF, IHC-P, IP, FC	Human, Mouse
	AKT1/2/3 Antibody (YA633) is a Rabbit-derived and non-conjugated IgG monoclonal antibody, targeting to AKT1/2/3.

HY-P84253

	AKT1 Antibody (YA3950) Akt; PKB; RAC; CWS6; PRKBA; PKB-ALPHA; RAC-ALPHA	WB, ICC/IF, FC, ELISA	Human, Mouse, Monkey, Rat
	AKT1 Antibody (YA3950) is a Mouse-derived and non-conjugated IgG1 monoclonal antibody, targeting to AKT1.

HY-P84254

	AKT1 Antibody (YA3951) Akt; PKB; RAC; CWS6; PRKBA; PKB-ALPHA; RAC-ALPHA	WB, IHC-P, FC, ELISA	Human, Rat, Monkey
	AKT1 Antibody (YA3951) is a Mouse-derived and non-conjugated IgG1 monoclonal antibody, targeting to AKT1.

HY-P83434

	PRAS40 Antibody (YA3179) Akt1S1; PRAS40; Proline-rich Akt1 substrate 1; 40 kDa proline-rich Akt substrate	WB, IP	Human, Rat
	PRAS40 Antibody (YA3179) is a Rabbit-derived and non-conjugated IgG monoclonal antibody, targeting to PRAS40.

HY-P86433

	PRAS40 Antibody (YA6125) Akt1S1; PRAS40; Proline-rich Akt1 substrate 1; 40 kDa proline-rich Akt substrate	WB, ICC/IF, IP, ELISA	Human, Mouse, Rat
	PRAS40 Antibody (YA6125) is a Rabbit-derived and non-conjugated IgG monoclonal antibody, targeting to PRAS40.

HY-P84253A

	AKT1 Antibody (YA3950)(PBS only) Akt; PKB; RAC; CWS6; PRKBA; PKB-ALPHA; RAC-ALPHA	WB, ICC/IF, FC, ELISA	Human, Mouse, Monkey, Rat
	AKT1 Antibody (YA3950) is a Mouse-derived and non-conjugated IgG1 monoclonal antibody, targeting to AKT1.

HY-P84254A

	AKT1 Antibody (YA3951)(PBS only) Akt; PKB; RAC; CWS6; PRKBA; PKB-ALPHA; RAC-ALPHA	WB, IHC-P, FC, ELISA	Human, Rat, Monkey
	AKT1 Antibody (YA3951) is a Mouse-derived and non-conjugated IgG1 monoclonal antibody, targeting to AKT1.

HY-P83434A

	PRAS40 Antibody (YA3179)(PBS only) Akt1S1; PRAS40; Proline-rich Akt1 substrate 1; 40 kDa proline-rich Akt substrate	WB, IP	Human, Rat
	PRAS40 Antibody (YA3179) is a Rabbit-derived and non-conjugated IgG monoclonal antibody, targeting to PRAS40.

HY-P86153

	Phospho-PRAS40(Thr246) Antibody (YA5845) Akt1S1; PRAS40; Proline-rich Akt1 substrate 1; 40 kDa proline-rich Akt substrate	WB, IHC-P, ICC/IF, IP, ELISA	Human, Mouse, Rat
	Phospho-PRAS40(Thr246) Antibody (YA5845) is a Rabbit-derived and non-conjugated IgG monoclonal antibody, targeting to Phospho-PRAS40(Thr246).

HY-P80788

	*Phospho-AKT1* (Ser473) Antibody (YA228)** 4 Publications Verification Akt1; PKB; RAC; RAC-alpha serine/threonine-protein kinase; Protein kinase B; PKB; Protein kinase B alpha; PKB alpha; Proto-oncogene c-Akt; RAC-PK-alpha	WB	Human, Mouse, Rat
	Phospho-AKT1 (Ser473) Antibody (YA228) is a Rabbit-derived and non-conjugated IgG monoclonal antibody, targeting to Phospho-AKT1 (Ser473).

HY-P810599

	*Phospho-AKT1* (Thr450) Antibody (YA9862)** Akt1; PKB; RAC; RAC-alpha serine/threonine-protein kinase; Protein kinase B; PKB; Protein kinase B alpha; PKB alpha; Proto-oncogene c-Akt; RAC-PK-alpha	WB, IHC-P, IP, ICC/IF, FC	Human, Mouse, Rat
	Phospho-AKT1 (Thr450) Antibody (YA9862) is a Rabbit-derived and non-conjugated IgG Recombinant, Monoclonal antibody, targeting to Phospho-AKT1 (Thr450).

HY-P810598

	*Phospho-AKT1* (Ser129) Antibody (YA9861)** Akt1; PKB; RAC; RAC-alpha serine/threonine-protein kinase; Protein kinase B; PKB; Protein kinase B alpha; PKB alpha; Proto-oncogene c-Akt; RAC-PK-alpha	WB	Human, Mouse, Rat
	Phospho-AKT1 (Ser129) Antibody (YA9861) is a Rabbit-derived and non-conjugated IgG Recombinant, Monoclonal antibody, targeting to Phospho-AKT1 (Ser129).

HY-P810600

	*Phospho-AKT1* (Ser124) Antibody (YA9863)** Akt1; PKB; RAC; RAC-alpha serine/threonine-protein kinase; Protein kinase B; PKB; Protein kinase B alpha; PKB alpha; Proto-oncogene c-Akt; RAC-PK-alpha	WB, ICC/IF, IF-Tissue, IHC-P, IP	Human, Mouse, Rat
	Phospho-AKT1 (Ser124) Antibody (YA9863) is a Rabbit-derived and non-conjugated IgG Recombinant, Monoclonal antibody, targeting to Phospho-AKT1 (Ser124).

HY-P80788A

	*Phospho-AKT1* (Ser473) Antibody (YA228)(PBS only)** Akt1; PKB; RAC; RAC-alpha serine/threonine-protein kinase; Protein kinase B; PKB; Protein kinase B alpha; PKB alpha; Proto-oncogene c-Akt; RAC-PK-alpha	WB	Human, Mouse, Rat
	Phospho-AKT1 (Ser473) Antibody (YA228) is a Rabbit-derived and non-conjugated IgG monoclonal antibody, targeting to Phospho-AKT1 (Ser473).

HY-P80789

	*Phospho-AKT* (Thr308) Antibody** 2 Publications Verification Akt1; PKB; RAC; RAC-alpha serine/threonine-protein kinase; Protein kinase B; PKB; Protein kinase B alpha; PKB alpha; Proto-oncogene c-Akt; RAC-PK-alpha	WB, IHC-P, ICC/IF, ELISA	Human, Mouse, Rat
	Phospho-AKT (Thr308) Antibody is a Rabbit-derived and non-conjugated IgG polyclonal antibody, targeting to Phospho-AKT (Thr308).

HY-P810597

	*Phospho-AKT* (Ser473) Antibody (YA9860)** Akt1; PKB; RAC; RAC-alpha serine/threonine-protein kinase; Protein kinase B; PKB; Protein kinase B alpha; PKB alpha; Proto-oncogene c-Akt; RAC-PK-alpha	WB, IHC-P, FC	Human, Mouse, Rat
	Phospho-AKT (Ser473) Antibody (YA9860) is a Rabbit-derived and non-conjugated IgG Recombinant, Monoclonal antibody, targeting to Phospho-AKT (Ser473).

HY-P80535

	AKT1+AKT2+AKT3 Antibody (YA635) 5 Publications Verification Akt1,Akt2,Akt3	WB, IHC-F, IHC-P, ICC/IF, IP	Human, Mouse, Rat, Hamster
	AKT1+AKT2+AKT3 Antibody (YA635) is a Rabbit-derived and non-conjugated IgG monoclonal antibody, targeting to AKT1+AKT2+AKT3.

HY-P80535A

	AKT1+AKT2+AKT3 Antibody (YA635)(PBS only) Akt1,Akt2,Akt3	WB, IHC-F, IHC-P, ICC/IF, IP	Human, Mouse, Rat, Hamster
	AKT1+AKT2+AKT3 Antibody (YA635) is a Rabbit-derived and non-conjugated IgG monoclonal antibody, targeting to AKT1+AKT2+AKT3.

HY-P86312

	AKT1/2/3 Antibody (YA6004) 2 Publications Verification	WB, IHC-P, ICC/IF, IP, ELISA	Human, Mouse, Rat
	AKT1/2/3 Antibody (YA6004) is a Rabbit-derived and non-conjugated IgG monoclonal antibody, targeting to AKT.