702674-56-4
702674-56-4
Chemical Structure
BX-912
- CAS No.: 702674-56-4
- Formula:C20H23BrN8O
- Molecular Weight:471.35
IUPAC Name: N-(3-((4-((2-(1H-imidazol-4-yl)ethyl)amino)-5-bromopyrimidin-2-yl)amino)phenyl)pyrrolidine-1-carboxamide
InChIKey: DMMILYKXNCVKOJ-UHFFFAOYSA-N
SMILES: BrC1=C(NCCC2=CNC=N2)N=C(NC3=CC(NC(N4CCCC4)=O)=CC=C3)N=C1
Biological Activity: BX-912 is a direct, selective, and ATP-competitive PDK1 inhibitor (IC50=26 nM). BX-912 blocks PDK1/Akt signaling in tumor cells and inhibits the anchorage-dependent growth of a variety of tumor cell lines in culture or induces apoptosis[1].
| Cat. No. | Product Name | Purity | Description | Pricing | |||||||||||||||||||
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BX-912 | 99.50% | BX-912 is a direct, selective, and ATP-competitive PDK1 inhibitor (IC50=26 nM). BX-912 blocks PDK1/Akt signaling in tumor cells and inhibits the anchorage-dependent growth of a variety of tumor cell lines in culture or induces apoptosis. | ||||||||||||||||||||
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BX-912 (Standard) | ≥98% | BX-912 (Standard) is the analytical standard of BX-912 (HY-11005). This product is intended for research and analytical applications. BX-912 is a direct, selective, and ATP-competitive PDK1 inhibitor (IC50=26 nM). BX-912 blocks PDK1/Akt signaling in tumor cells and inhibits the anchorage-dependent growth of a variety of tumor cell lines in culture or induces apoptosis. | ||||||||||||||||||||
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Structural Analogs
-
Similarity Score 0.69
HY-10515BX-320 -
Similarity Score 0.64
HY-10514BX795 -
Similarity Score 0.54
HY-148483SR8185 -
Similarity Score 0.53
HY-183099TBK1 ligand 3 -
Similarity Score 0.53
HY-119396DY3002 -
Similarity Score 0.53
HY-131063CDK6/9-IN-1 -
Similarity Score 0.52
HY-18315Bayer-18 -
Similarity Score 0.52
HY-146132EGFR-IN-55 -
Similarity Score 0.51
HY-176334TBK1 ligand 2 -
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