3 Results for "

Angiostrongylus cantonensis

" in MedChemExpress (MCE) Product Catalog:
Products (3)

3 Results for "Angiostrongylus cantonensis" in MCE Product Catalog:

5
[10]-Shogaol
[10]-Shogaol
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5 Cited Publications
Cat. No.: HY-N2434
CAS No.: 36752-54-2
Category:  

Zingiber officinale Roscoe Monophenols Phenols Plants Disease Research Fields Cancer Zingiberaceae

Target:  

COX Interleukin Related NF-κB Parasite

[10]-Shogaol is an orally active antioxidant. [10]-Shogaol can be extracted from ginger (Zingiber officinale). [10]-Shogaol1 inhibits COX-2 with an IC50 value of 7.5 μM. [10]-Shogaol inhibits the production of proinflammatory cytokines (IL-1β, IL-6). [10]-Shogaol inhibits NF-κB phosphorylation. [10]-Shogaol has anti-inflammatory effects. [10]-Shogaol has anticancer effects against Docetaxel (HY-B0011)-resistant prostate cancer. [10]-Shogaol exhibits larvicidal activity against L5 larvae of Angiostrongylus cantonensis .
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Cubebin
Cubebin
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Cat. No.: HY-N10423
CAS No.: 18423-69-3
Synonyms: (-)-Cubebin
Category:  

Lignans Piperaceae Piper cubeba L.f. Phenylpropanoids Plants Disease Research Fields Inflammation/Immunology

Target:  

Cholinesterase (ChE) Bacterial Fungal Parasite p38 MAPK

Cubebin ((-)-Cubebin), a dibenzyl butyrolactone lignan, is an orally active AChE inhibitor. Cubebin binds to active sites of NF-κB, TNF-α, and TGF-β1 via hydrogen and hydrophobic interactions, obstructing critical residues to inhibit pro-inflammatory or renal fibrosis-related activity. Cubebin enhances p38 MAPK phosphorylation to increase tyrosinase gene expression, stimulating melanogenesis via elevated tyrosinase activity, expression, and mRNA levels. Cubebin reduces oxidative stress via enhanced endogenous antioxidant enzyme activity and inhibited lipid peroxidation, regulates lipid metabolism, improves glycemic control, and exerts renoprotective effects via reduced renal dysfunction markers and improved renal architecture. Cubebin shows antimicrobial activity. Cubebin exerts larvicidal activity against Angiostrongylus cantonensis larvae, with no cytotoxicity toward monkey or human cell lines or Caenorhabditis elegans. Cubebin can be used for the research of diabetic nephropathy, melanoma, colon adenocarcinoma, neuroangiostrongyliasis, Alzheimer’s disease (AD) and depression .
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[10]-Shogaol (Standard)
[10]-Shogaol (Standard)
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Cat. No.: HY-N2434R
CAS No.: 36752-54-2
Category:  

Zingiber officinale Roscoe Monophenols Phenols Plants Zingiberaceae

Target:  

Reference Standards COX Interleukin Related NF-κB Parasite

-Shogaol (Standard) is the analytical standard of -Shogaol (HY-N2434). This product is intended for research and analytical applications. [10]-Shogaol is an orally active antioxidant. [10]-Shogaol can be extracted from ginger (Zingiber officinale). [10]-Shogaol1 inhibits COX-2 with an IC50 value of 7.5 μM. [10]-Shogaol inhibits the production of proinflammatory cytokines (IL-1β, IL-6). [10]-Shogaol inhibits NF-κB phosphorylation. [10]-Shogaol has anti-inflammatory effects. [10]-Shogaol has anticancer effects against Docetaxel (HY-B0011)-resistant prostate cancer. [10]-Shogaol exhibits larvicidal activity against L5 larvae of Angiostrongylus cantonensis .
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