Scientific Reviews
Product Guides
Blogs
Topics
Targeted therapy! The Capetin Prize winning "Click Chemistry" can be used like this!Targeted therapy! The Nobel Prize winning "Click Chemistry" can be used like this!2025-02-06
12 Results for "
BTK-IN-3
" in MedChemExpress (MCE) Product Catalog:
Products (12)
12 Results for "BTK-IN-3" in MCE Product Catalog:
1
1 Cited Publications
TL12-186 is a Cereblon-dependent multi-kinase PROTAC degrader. Multi-kinases include CDK, BTK, FLT3, Aurora kinases, TEC, ULK, ITK, et al. TL12-186 inhibits CDK2/cyclin A (IC50=73 nM) and CDK9/cyclin T1 (IC50=55 nM) .
Cat. No.: HY-153536
CAS No.: 2563861-90-3
PROTAC BTK Degrader-3 is an orally active PROTAC degrader targeting BTK, with a DC50 value of 10.9 nM. PROTAC BTK Degrader-3 has an IC50 of 6.3 nM against wild-type BTK and an IC50 of 8 nM against BTK C481S. PROTAC BTK Degrader-3 can be used in cancer-related research .
Cat. No.: HY-146672
CAS No.: 2404604-06-2
ITK inhibitor 6 (compound 43) is a potent and selective ITK inhibitor with IC50s of 4 nM, 133 nM, 320 nM, 2360 nM, 155 nM for ITK, BTK, JAK3, EGFR, LCK, respectively. ITK inhibitor 6 inhibits phosphorylation of PLCγ1 and ERK1/2. ITK inhibitor 6 shows antiproliferative activities .
Cat. No.: HY-143718
CAS No.: 2674036-98-5
Research Areas:
JAK3/BTK-IN-3 is a potent inhibitor of JAK3/BTK. BTK and JAK3 are two important targets for autoimmune diseases. Simultaneous inhibition of the BTK/JAK3 signalling pathway exhibits synergistic effects. JAK3/BTK-IN-3 has the potential for the research of JAK3 kinase and/or BTK-related diseases (extracted from patent WO2021147952A1, compound 009)
Cat. No.: HY-147741
CAS No.: 2095883-62-6
Research Areas:
DPPY (compound 6) is a potent PTK inhibitor with IC50 values of <10, <10, <10 nM for EGFR, BTK, JAK3, respectively. DPPY shows anti-proliferative activity against B-cell lymphoma cells. DPPY has the potential for the research of idiopathic pulmonary fibrosis (IPF) .
Cat. No.: HY-143716
CAS No.: 2674036-91-8
Research Areas:
JAK3/BTK-IN-1 is a potent inhibitor of JAK3/BTK. BTK and JAK3 are two important targets for autoimmune diseases. Simultaneous inhibition of the BTK/JAK3 signalling pathway exhibits synergistic effects. JAK3/BTK-IN-1 has the potential for the research of JAK3 kinase and/or BTK-related diseases (extracted from patent WO2021147952A1, compound 002) .
Cat. No.: HY-143717
CAS No.: 2674036-93-0
Research Areas:
JAK3/BTK-IN-2 is a potent inhibitor of JAK3/BTK. BTK and JAK3 are two important targets for autoimmune diseases. Simultaneous inhibition of the BTK/JAK3 signalling pathway exhibits synergistic effects. JAK3/BTK-IN-2 has the potential for the research of JAK3 kinase and/or BTK-related diseases (extracted from patent WO2021147952A1, compound 004)
Cat. No.: HY-143719
CAS No.: 2673196-38-6
Research Areas:
JAK3/BTK-IN-4 is a potent inhibitor of JAK3/BTK. BTK and JAK3 are two important targets for autoimmune diseases. Simultaneous inhibition of the BTK/JAK3 signalling pathway exhibits synergistic effects. JAK3/BTK-IN-4 has the potential for the research of JAK3 kinase and/or BTK-related diseases (extracted from patent WO2021147953A1, compound 003)
Cat. No.: HY-143720
CAS No.: 2673196-75-1
Research Areas:
JAK3/BTK-IN-5 is a potent inhibitor of JAK3/BTK. BTK and JAK3 are two important targets for autoimmune diseases. Simultaneous inhibition of the BTK/JAK3 signalling pathway exhibits synergistic effects. JAK3/BTK-IN-5 has the potential for the research of JAK3 kinase and/or BTK-related diseases (extracted from patent WO2021147953A1, example 35)
Cat. No.: HY-150898
CAS No.: 2192282-58-7
Research Areas:
BTK ligand 3 is a BTK ligand that can be used for the synthesis of PROTACs, such as PROTAC BTK Degrader-5 (HY-155072) .
Cat. No.: HY-W125996
CAS No.: 928114-07-2
Synonyms: 1-(3-AzetidINyl)-azetidINe
Target:
Research Areas:
1-(Azetidin-3-yl)azetidine (1-(3-Azetidinyl)-azetidine) is a PROTAC linker. 1-(Azetidin-3-yl)azetidine can be used to synthesize PROTAC BTK Degrader-3 (HY-153536) .
- 1
-
-
Protocols
Targeted therapy! The Capetin Prize winning "Click Chemistry" can be used like this!Targeted therapy! The Nobel Prize winning "Click Chemistry" can be used like this!A suitable model is crucial in drug screening experiments. Organs can mimic the three-dimensional functional structure of internal organs, have similar spatial organization to corresponding organs, maintain some key characteristics, and reproduce some physiological functions. They are widely used for modeling and personalized drug screening physiological functions.2025-02-06
