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Results for "

BV-2 microglia

" in MedChemExpress (MCE) Product Catalog:

By Targets:	Amyloid-β (1) Anaplastic lymphoma kinase (ALK) (1) Apoptosis (2) Epigenetic Reader Domain (1) ERK (1) Ferroptosis (1) Fungal (1) GPR109A (1) IKK (1) Interleukin Related (4) JNK (1) Keap1-Nrf2 (1) MEK (1) MMP (1) NF-κB (6) NO Synthase (8) NOD-like Receptor (NLR) (2) p38 MAPK (3) Prostaglandin Receptor (1) PROTACs (1) Reactive Oxygen Species (ROS) (1) Src (1) TNF Receptor (5) Toll-like Receptor (TLR) (1) VEGFR (1)
By Research Areas:	Cancer (1) Cardiovascular Disease (1) Inflammation/Immunology (16) Metabolic Disease (2) Neurological Disease (10)

By Targets:

Amyloid-β (1)

Anaplastic lymphoma kinase (ALK) (1)

Apoptosis (2)

Epigenetic Reader Domain (1)

ERK (1)

Ferroptosis (1)

Fungal (1)

GPR109A (1)

IKK (1)

Interleukin Related (4)

JNK (1)

Keap1-Nrf2 (1)

MEK (1)

MMP (1)

NF-κB (6)

NO Synthase (8)

NOD-like Receptor (NLR) (2)

p38 MAPK (3)

Prostaglandin Receptor (1)

PROTACs (1)

Reactive Oxygen Species (ROS) (1)

Src (1)

TNF Receptor (5)

Toll-like Receptor (TLR) (1)

VEGFR (1)

By Research Areas:

Cancer (1)

Cardiovascular Disease (1)

Inflammation/Immunology (16)

Metabolic Disease (2)

Neurological Disease (10)

Inhibitors & Agonists

Natural
Products

Cat. No.	Product Name	Target	Research Areas	Chemical Structure

HY-N0442

5-O-Methylvisammioside 4'-O-β-D-Glucosyl-5-O-methylvisamminol	NF-κB p38 MAPK JNK Src TNF Receptor NOD-like Receptor (NLR) Amyloid-β MEK ERK Ferroptosis VEGFR Anaplastic lymphoma kinase (ALK) Reactive Oxygen Species (ROS)	Neurological Disease Metabolic Disease Inflammation/Immunology Cancer
5-O-Methylvisammioside (4'-O-β-D-Glucosyl-5-O-methylvisamminol) is an orally active natural chromone glycoside and multiple biological activities. 5-O-Methylvisammioside inhibits ferroptosis by activating the Nrf2/HO-1 signaling axis. 5-O-Methylvisammioside alleviates intestinal barrier damage by inhibiting the ROS/NF-κB/NLRP3 pathway. 5-O-Methylvisammioside exerts a protective effect against acute liver injury by reducing ALT/AST, decreasing inflammatory infiltration, and inhibiting IκB-α phosphorylation and NF-κB nuclear translocation. 5-O-Methylvisammioside blocks the HMGB1/RAGE/MEK/ERK signaling axis to exert anti-tumor and anti-angiogenic effects. 5-O-Methylvisammioside improves depression-like behaviors by inhibiting Src kinase and the NF-κB pathway .

HY-19667A

BMS-561392 formate 2 Publications Verification DPC 333 formate	TNF Receptor NF-κB Apoptosis p38 MAPK	Neurological Disease Inflammation/Immunology
BMS-561392 formate (DPC 333 formate) is a selective ADAM17(TACE) inhibitor. BMS-561392 formate inhibits TNF-α secretion by regulating signaling pathways such as p44 MAPK and NF-κB. BMS-561392 formate also affects the survival of central nervous system-related cells including oligodendrocytes and microglia. BMS-561392 formate promotes microglial apoptosis, enlarges the injury area and exacerbates astrogliosis in a mouse spinal cord injury model. BMS-561392 formate can be used in research related to spinal cord injury and inflammatory diseases .

HY-107581

MK-1903 1 Publications Verification	GPR109A MMP	Metabolic Disease Inflammation/Immunology
MK-1903 is an orally active full agonist of GPR109a/HCAR2, with an EC₅₀ of 12.9 nM. MK-1903 activates antilipolytic and vasodilatory pathways, reduces plasma free fatty acid levels, and induces skin flushing. MK-1903 stimulates the expression of HCAR2 protein and regulates the inflammatory response of microglia. MK-1903 prevents the enhanced firing activity of spinal nociceptive neurons. MK-1903 triggers the release of MMP-9 and the formation of NET. MK-1903 can be used in the research of dyslipidemia and neuroinflammation-based central nervous system diseases .

HY-19667

BMS-561392 DPC 333	TNF Receptor NF-κB Apoptosis p38 MAPK	Neurological Disease Inflammation/Immunology
BMS-561392 (BMS-561392) is a selective ADAM17(TACE) inhibitor. BMS-561392 inhibits TNF-α secretion by regulating signaling pathways such as p44 MAPK and NF-κB. BMS-561392 also affects the survival of central nervous system-related cells including oligodendrocytes and microglia. BMS-561392 promotes microglial apoptosis, enlarges the injury area and exacerbates astrogliosis in a mouse spinal cord injury model. BMS-561392 can be used in research related to spinal cord injury and inflammatory diseases .

HY-164049

TG8-260	Prostaglandin Receptor	Inflammation/Immunology
TG8-260 is a second-generation EP2 antagonist developed to alleviate the pathology of central nervous system and peripheral diseases driven by inflammation. TG8-260 can reduce neuroinflammation and gliosis in the hippocampus of rats after pilocarpine-induced persistent epileptic status. Pharmacokinetic data of TG8-260 showed that its plasma half-life was 2.14 hours and its oral bioavailability was 77.3%. TG8-260 is also a potent inhibitor of CYP450 and shows antagonistic activity in inhibiting EP2 receptor-mediated inflammatory gene expression in BV2-hEP2 microglia, which is suitable for studying anti-inflammatory pathways in animal models of peripheral inflammatory diseases .

HY-N3915

Futoquinol	NO Synthase	Neurological Disease Inflammation/Immunology
Futoquinol is a neolignan isolated from the dried aerial parts of Piper kadsura (Piperaceae). Futoquinol potently inhibits NO production in microglia cells. Futoquinol has anti-neuroinflammatory activities .

HY-N8090

(3β,7β,12β,20Z)-3,7,12-Trihydroxy-11,15,23-trioxo-lanost-8,20-dien-26-oic acid	NO Synthase	Inflammation/Immunology
(3β,7β,12β,20Z)-3,7,12-Trihydroxy-11,15,23-trioxo-lanost-8,20-dien-26-oic acid, a lanostane triterpenoids, exhibits obvious NO inhibitory activity on n LPS-induced BV-2 microglia cells with an IC₅₀ of 9.55 uM. (3β,7β,12β,20Z)-3,7,12-Trihydroxy-11,15,23-trioxo-lanost-8,20-dien-26-oic acid has anti-inflammatory activities .

HY-N10386

Dichotomine B	Others	Inflammation/Immunology
Dichotomine B, a β-Carboline alkaloid, attenuates neuroinflammatory responses in LPS/ATP-induced BV2 microglia .

HY-119465

Restricticin	Fungal	Others
Restricticin is a compound obtained from marine fungi, whose structure contains alkene, tetrahydropyran ring and glycine ester functional groups, and has anti-neuroinflammatory effects in lipopolysaccharide-induced BV-2 microglia by inhibiting the production of proinflammatory mediators.

HY-N9675

(+)-Hannokinol	NO Synthase	Inflammation/Immunology
(+)-Hannokinol can be isolated from AMOMUM TSAO-KO (ginger family) fruit. (+)-Hannokinol inhibits lipopolysaccharide-induced nitric oxide production in BV2 microglia .

HY-155762

Anti-neuroinflammation agent 1	NOD-like Receptor (NLR) Interleukin Related	Neurological Disease Inflammation/Immunology
Anti-neuroinflammation agent 1 is a potent anti-neuroinflammation agent that regulates polarization BV2 microglia cells from M1 phenotype to M2 phenotype .

HY-N7018

20-Hydroxyganoderic Acid G	Others	Inflammation/Immunology
20-Hydroxyganoderic Acid G is a lanostane triterpenoid obtained from the EtOH extract of fruiting bodies of the Ganoderma curtisii. 20-Hydroxyganoderic Acid G inhibits BV-2 microglia cells activated by LPS with an IC₅₀ of 21.33 μM. 20-Hydroxyganoderic Acid G has therapeutic potential in the agent discovery of nerve inflammation diseases associated with microglia activated by LPS .

HY-N0859B

Schisanchinin D	NO Synthase	Neurological Disease
Schisanchinin D is an NO release inhibitor found in the fruits of Schisandra chinensis. Schisanchinin D can inhibit the release of nitric oxide (NO) by lipopolysaccharide (LPS)-activated microglia in primary murine BV2 microglia cells. Schisanchinin D is promising for research of neurodegenerative diseases such as Alzheimer's disease (AD) .

HY-N3814

ent-16β,17-Dihydroxykauran-19-oic acid	Others	Inflammation/Immunology
ent-16β,17-Dihydroxykauran-19-oic acid is an anti-inflammatory agent, which can be isolated from Siegesbeckia pubescens herb. ent-16β,17-Dihydroxykauran-19-oic acid inhibits lipopolysaccharide-induced nitric oxide production in BV2 microglia .

HY-N10458

Asperbisabolane L	NF-κB	Inflammation/Immunology
Asperbisabolane L, a sesquiterpenoid, exerts the anti-inflammatory activity by inhibiting the NF-κB-activated pathway. Asperbisabolane L inhibits the translocation of NF-κB from cytoplasm to the nucleus. Asperbisabolane L also inhibits NO production in LPS-activated BV-2 microglia cells .

HY-N13729

Stephalonine P	NO Synthase	Cardiovascular Disease Neurological Disease
Stephalonine P is a hasubanan-type alkaloid anti-inflammatory agent with neuroprotective effects against neuroinflammation. Stephalonine P regulates post-ischemic inflammatory responses by inhibiting NO production in LPS-activated BV2 microglia (IC₅₀=34.01 μM), thereby reducing microglial activation and neuronal damage. Stephalonine P can be isolated from the whole plant of Stephania japonica. Stephalonine P can be used in research on stroke and other neuroinflammation-related diseases .

HY-180889

PROTAC BRD3 degrader-1	PROTACs Epigenetic Reader Domain	Neurological Disease Inflammation/Immunology
PROTAC BRD3 degrader-1 (compound D072) is a potent and selective PROTAC BRD3 degrader. PROTAC BRD3 degrader-1 selectively degrades BRD3 in mice, leading to the downregulation of H3K18ac without affecting BRD2 or BRD4. PROTAC BRD3 degrader-1 reduces intraocular inflammation in the experimental autoimmune uveitis (EAU) mouse mode and inhibits proinflammatory microglia in both uveitis retina and LPS (HY-D1056) treated mouse microglia cell line BV2. PROTAC BRD3 degrader-1 can be used for uveitis research .

HY-181818

4,5-Dehydro-6-oxoallosecurinine	Keap1-Nrf2 NO Synthase TNF Receptor Interleukin Related	Neurological Disease Inflammation/Immunology
4,5-Dehydro-6-oxoallosecurinine is a Keap1-Nrf2 pathway activator. 4,5-Dehydro-6-oxoallosecurinine promotes the nuclear translocation of Keap1-Nrf2, and induces the expression of antioxidant and cytoprotective genes. 4,5-Dehydro-6-oxoallosecurinine reduces the production of NO, and decreases the levels of iNOS, TNF-α, IL-6 and IL-1β in LPS-stimulated microglia. 4,5-Dehydro-6-oxoallosecurinine can be used for the research of neurodegenerative diseases .

HY-N17562

Acutissimalignan B	NO Synthase Interleukin Related IKK NF-κB	Inflammation/Immunology
Acutissimalignan B is a natural product. Acutissimalignan B can be isolated from Daphne kiusiana var. atrocaulis (Rehd.) F. Maekawa. Acutissimalignan B can reduce the mRNA expression of inflammatory cytokines (iNOS, TNF-α, IL-1β, and IL-6), inhibit the phosphorylation of IκBα, and inhibit the nuclear translocation of NK-κB p65. Acutissimalignan B shows anti-neuroinflammatory effects .

HY-179646

CIAC101	Toll-like Receptor (TLR) NO Synthase NF-κB TNF Receptor Interleukin Related	Neurological Disease
CIAC101 is a potent and brain-penetrant TLR4 antagonist with an IC₅₀ of 17.0 nM in NO assay. CIAC101 blocks Lipopolysaccharides (HY-D1056) (LPS)-induced NF-κB activation and reduces the expression of pro-inflammatory mediators (iNOS, IL-1β, TNF-α, and IL-6). CIAC101 robust antineuroinflammatory activity with efficacy against drug-evoked neurobehavioral adaptations. CIAC101 can be used for the research of addiction and neurological disease .

5-O-Methylvisammioside 4'-O-β-D-Glucosyl-5-O-methylvisamminol	Structural Classification Ophryosporus axilliflorus Hieron. Classification of Application Fields Ketones, Aldehydes, Acids Other Diseases Umbelliferae Plants Disease Research Fields Source Classification	NF-κB p38 MAPK JNK Src TNF Receptor NOD-like Receptor (NLR) Amyloid-β MEK ERK Ferroptosis VEGFR Anaplastic lymphoma kinase (ALK) Reactive Oxygen Species (ROS)
5-O-Methylvisammioside (4'-O-β-D-Glucosyl-5-O-methylvisamminol) is an orally active natural chromone glycoside and multiple biological activities. 5-O-Methylvisammioside inhibits ferroptosis by activating the Nrf2/HO-1 signaling axis. 5-O-Methylvisammioside alleviates intestinal barrier damage by inhibiting the ROS/NF-κB/NLRP3 pathway. 5-O-Methylvisammioside exerts a protective effect against acute liver injury by reducing ALT/AST, decreasing inflammatory infiltration, and inhibiting IκB-α phosphorylation and NF-κB nuclear translocation. 5-O-Methylvisammioside blocks the HMGB1/RAGE/MEK/ERK signaling axis to exert anti-tumor and anti-angiogenic effects. 5-O-Methylvisammioside improves depression-like behaviors by inhibiting Src kinase and the NF-κB pathway .

Futoquinol	Other Phenylpropanoids Piperaceae Phenylpropanoids Plants Piper kadsura (Choisy) Ohwi Source Classification	NO Synthase
Futoquinol is a neolignan isolated from the dried aerial parts of Piper kadsura (Piperaceae). Futoquinol potently inhibits NO production in microglia cells. Futoquinol has anti-neuroinflammatory activities .

(3β,7β,12β,20Z)-3,7,12-Trihydroxy-11,15,23-trioxo-lanost-8,20-dien-26-oic acid	Triterpenes Microorganisms Classification of Application Fields Terpenoids Inflammation/Immunology Disease Research Fields Source Classification	NO Synthase
(3β,7β,12β,20Z)-3,7,12-Trihydroxy-11,15,23-trioxo-lanost-8,20-dien-26-oic acid, a lanostane triterpenoids, exhibits obvious NO inhibitory activity on n LPS-induced BV-2 microglia cells with an IC₅₀ of 9.55 uM. (3β,7β,12β,20Z)-3,7,12-Trihydroxy-11,15,23-trioxo-lanost-8,20-dien-26-oic acid has anti-inflammatory activities .

Dichotomine B	Alkaloids Classification of Application Fields Stellaria dichotoma var. lanceolata Bge. Pyridine Alkaloids Plants Inflammation/Immunology Disease Research Fields Caryophyllaceae Indole Alkaloids Source Classification	Others
Dichotomine B, a β-Carboline alkaloid, attenuates neuroinflammatory responses in LPS/ATP-induced BV2 microglia .

Restricticin	Microorganisms Antibiotics Other Antibiotics Source Classification	Fungal
Restricticin is a compound obtained from marine fungi, whose structure contains alkene, tetrahydropyran ring and glycine ester functional groups, and has anti-neuroinflammatory effects in lipopolysaccharide-induced BV-2 microglia by inhibiting the production of proinflammatory mediators.

(+)-Hannokinol	Structural Classification Amomum tsaoko Crevost et Lemarie Phenols Polyphenols Plants Source Classification Zingiberaceae	NO Synthase
(+)-Hannokinol can be isolated from AMOMUM TSAO-KO (ginger family) fruit. (+)-Hannokinol inhibits lipopolysaccharide-induced nitric oxide production in BV2 microglia .

20-Hydroxyganoderic Acid G	Triterpenes Classification of Application Fields Terpenoids Polyporaceae Plants Inflammation/Immunology Disease Research Fields Source Classification	Others
20-Hydroxyganoderic Acid G is a lanostane triterpenoid obtained from the EtOH extract of fruiting bodies of the Ganoderma curtisii. 20-Hydroxyganoderic Acid G inhibits BV-2 microglia cells activated by LPS with an IC₅₀ of 21.33 μM. 20-Hydroxyganoderic Acid G has therapeutic potential in the agent discovery of nerve inflammation diseases associated with microglia activated by LPS .

Schisanchinin D	Lignans Phenylpropanoids Plants Schisandraceae Schisandra chinensis (Turcz.) Baill. Source Classification	NO Synthase
Schisanchinin D is an NO release inhibitor found in the fruits of Schisandra chinensis. Schisanchinin D can inhibit the release of nitric oxide (NO) by lipopolysaccharide (LPS)-activated microglia in primary murine BV2 microglia cells. Schisanchinin D is promising for research of neurodegenerative diseases such as Alzheimer's disease (AD) .

ent-16β,17-Dihydroxykauran-19-oic acid	Terpenoids Diterpenoids Plants Compositae Tephrosia candida DC. Source Classification	Others
ent-16β,17-Dihydroxykauran-19-oic acid is an anti-inflammatory agent, which can be isolated from Siegesbeckia pubescens herb. ent-16β,17-Dihydroxykauran-19-oic acid inhibits lipopolysaccharide-induced nitric oxide production in BV2 microglia .

Asperbisabolane L	Structural Classification Microorganisms Sesquiterpenes Source Classification	NF-κB
Asperbisabolane L, a sesquiterpenoid, exerts the anti-inflammatory activity by inhibiting the NF-κB-activated pathway. Asperbisabolane L inhibits the translocation of NF-κB from cytoplasm to the nucleus. Asperbisabolane L also inhibits NO production in LPS-activated BV-2 microglia cells .

Stephalonine P	Structural Classification Alkaloids Other Alkaloids Plants Menispermaceae Stephania japonica (Thunb.) Miers Source Classification	NO Synthase
Stephalonine P is a hasubanan-type alkaloid anti-inflammatory agent with neuroprotective effects against neuroinflammation. Stephalonine P regulates post-ischemic inflammatory responses by inhibiting NO production in LPS-activated BV2 microglia (IC₅₀=34.01 μM), thereby reducing microglial activation and neuronal damage. Stephalonine P can be isolated from the whole plant of Stephania japonica. Stephalonine P can be used in research on stroke and other neuroinflammation-related diseases .

Acutissimalignan B	Structural Classification Daphne kiusiana Miq. Thymelaeaceae Lignans Phenylpropanoids Plants Source Classification	NO Synthase Interleukin Related IKK NF-κB
Acutissimalignan B is a natural product. Acutissimalignan B can be isolated from Daphne kiusiana var. atrocaulis (Rehd.) F. Maekawa. Acutissimalignan B can reduce the mRNA expression of inflammatory cytokines (iNOS, TNF-α, IL-1β, and IL-6), inhibit the phosphorylation of IκBα, and inhibit the nuclear translocation of NK-κB p65. Acutissimalignan B shows anti-neuroinflammatory effects .

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BV-2 microglia

Inhibitors & Agonists

NaturalProducts

Natural
Products