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Targeted therapy! The Capetin Prize winning "Click Chemistry" can be used like this!Targeted therapy! The Nobel Prize winning "Click Chemistry" can be used like this!2025-02-06
68 Results for "
CCL2
" in MedChemExpress (MCE) Product Catalog:
Products (68)
68 Results for "CCL2" in MCE Product Catalog:
103
Target:
Research Areas:
Pirfenidone (AMR69) is an antifibrotic agent that attenuates CCL2 and CCL12 production in fibrocyte cells. Pirfenidone has growth-inhibitory effect and reduces TGF-β2 protein levels in human glioma cell lines. Pirfenidone also has anti-inflammatory activities [2] .
32
Category:
Umbelliferae/Apiaceae Extract Plant Neurological Disease Ketones, Aldehydes, Acids Disease Research Fields Endocrinology Cancer Angelica sinensis (Oliv.) Diels Extract
Target:
10
10 Cited Publications
Cat. No.: HY-P7764
Purity: ≥ 95%, as determined by reducing SDS-PAGE.
Synonyms: CCL2; Small Inducible Cytokine Subfamily A (Cys-Cys), Member 2; Prev. SCYA2; Chemokine (C-C Motif) Ligand 2; MCP-1; Monocyte Chemotactic Protein 1; MCP1; Small-Inducible Cytokine A2; MCAF; C-C Motif Chemokine 2; HC11; MGC9434; Monocyte Chemotactic And Act
Species:
Mouse
Source:
E. coli
10
10 Cited Publications
Cat. No.: HY-P7237
Purity: ≥ 95%, as determined by reducing SDS-PAGE.
Synonyms: CCL2; Small Inducible Cytokine Subfamily A (Cys-Cys), Member 2; Prev. SCYA2; Chemokine (C-C Motif) Ligand 2; MCP-1; Monocyte Chemotactic Protein 1; MCP1; Small-Inducible Cytokine A2; MCAF; C-C Motif Chemokine 2; HC11; MGC9434; Monocyte Chemotactic And Activating Factor; Monocyte Chemotactic Protein 1, Homologous To Mouse Sig-Je; Monocyte Secretory Protein JE; Chemokine (C-C Motif) Ligand 2, Isoform CRA_a; SMC-CF; Monocyte Chemoattractant Protein 1; GDCF-2; HSMCR30; Small Inducible Cytokine A2 (Monocyte Chemotactic Protein 1, Homologous To Mouse Sig-Je); C-C Motif Chemokine Ligand 2; Monocyte Chemoattractant Protein-1
Species:
Human
Source:
E. coli
5
Carlumab (CNTO 888) is a human anti-CCL2 (chemokine ligand 2) monoclonal antibody. Carlumab binds to human CCL2 and neutralizes its pro-fibrotic activity. Carlumab inhibits tumor growth by reducing macrophage infiltration and decreasing tumor microvessel density. Carlumab can be used in cancer research, such as prostate cancer [2].
4
4 Cited Publications
Cat. No.: HY-P700034AF
Purity: ≥ 95%, as determined by reducing SDS-PAGE.
Synonyms: CCL2; Small Inducible Cytokine Subfamily A (Cys-Cys), Member 2; Prev. SCYA2; Chemokine (C-C Motif) Ligand 2; MCP-1; Monocyte Chemotactic Protein 1; MCP1; Small-Inducible Cytokine A2; MCAF; C-C Motif Chemokine 2; HC11; MGC9434; Monocyte Chemotactic And Activating Factor; Monocyte Chemotactic Protein 1, Homologous To Mouse Sig-Je; Monocyte Secretory Protein JE; Chemokine (C-C Motif) Ligand 2, Isoform CRA_a; SMC-CF; Monocyte Chemoattractant Protein 1; GDCF-2; HSMCR30; Small Inducible Cytokine A2 (Monocyte Chemotactic Protein 1, Homologous To Mouse Sig-Je); C-C Motif Chemokine Ligand 2; Monocyte Chemoattractant Protein-1
Species:
Human
Source:
E. coli
2
2 Cited Publications
Target:
Research Areas:
XT2 is a selective NIK inhibitor with an IC50 of 9.1 nM. XT2 dose-dependently inhibits the mRNA of TNFα, CCL2, CCL5, CXCL5, and NOS2. XT2 reduces serum ALT. XT2 can be used for research on CCl4 (HY-Y0298)-induced liver injury .
2
2 Cited Publications
Cat. No.: HY-P7235
Purity: ≥ 95%, as determined by reducing SDS-PAGE.
Synonyms: CCL2; Small Inducible Cytokine Subfamily A (Cys-Cys), Member 2; Prev. SCYA2; Chemokine (C-C Motif) Ligand 2; MCP-1; Monocyte Chemotactic Protein 1; MCP1; Small-Inducible Cytokine A2; MCAF; C-C Motif Chemokine 2; HC11; MGC9434; Monocyte Chemotactic And Act
Species:
Mouse
Source:
HEK293
1
1 Cited Publications
Cat. No.: HY-P990297
Research Areas:
1
1 Cited Publications
Synonyms: HMS; 6α-Methyl-11β-hydroxyprogesterone
Target:
Research Areas:
Medrysone (HMS) is a glucocorticoid receptor modulator and a STAT6 pathway enhancer. Medrysone enhances cytokine-induced STAT6 phosphorylation, which is required for M2-type macrophage polarization, and promotes VEGF and CCL2 secretion, vascular endothelial cell migration, and corneal injury repair. Medrysone can be used in research on corneal injury and elevated intraocular pressure [2] .
1
Target:
Research Areas:
Emapticap pegol (NOX-E36) is a inhibitor of pro-inflammatory chemokine C-C motif-ligand 2 (CCL2). Emapticap pegol is a 40-nucleotide pegylated aptamer, displays different Spiegelmers (L-RNA aptamer) isform in human (NOX-E36) and mouse (mNOX-E36). mNOX-E36 is a murine-specific analogue of NOX-E36, an anti-MCP-1 L-RNA aptamer that was previously shown to attenuate liver fibrosis in mice [2] .
1
Emapticap pegol sodium is a inhibitor of pro-inflammatory chemokine C-C motif-ligand 2 (CCL2). Emapticap pegol sodium is a 40-nucleotide pegylated aptamer, displays different Spiegelmers (L-RNA aptamer) isform in human (NOX-E36) and mouse (mNOX-E36) [2] .
1
1 Cited Publications
Cat. No.: HY-P78173
Purity: ≥ 95%, as determined by Bis-Tris PAGE.
Synonyms: CCL2; Small Inducible Cytokine Subfamily A (Cys-Cys), Member 2; Prev. SCYA2; Chemokine (C-C Motif) Ligand 2; MCP-1; Monocyte Chemotactic Protein 1; MCP1; Small-Inducible Cytokine A2; MCAF; C-C Motif Chemokine 2; HC11; MGC9434; Monocyte Chemotactic And Act
Species:
Human
Source:
HEK293
1
1 Cited Publications
Cat. No.: HY-P7236
Purity: ≥ 95%, as determined by reducing SDS-PAGE.
Synonyms: CCL2; Small Inducible Cytokine Subfamily A (Cys-Cys), Member 2; Prev. SCYA2; Chemokine (C-C Motif) Ligand 2; MCP-1; Monocyte Chemotactic Protein 1; MCP1; Small-Inducible Cytokine A2; MCAF; C-C Motif Chemokine 2; HC11; MGC9434; Monocyte Chemotactic And Act
Species:
Rat
Source:
HEK293
Research Areas:
Neurological Disease Metabolic Disease Inflammation/Immunology Cancer
Fludrocortisone (9α-Fludrocortisone) is an orally active mineralocorticoid and glucocorticoid receptor agonist. Fludrocortisone suppresses pro-inflammatory cytokine expression, reduces CCL2, IL-6, IL-8 levels, upregulates mineralocorticoid receptor (MR) expression, induces PI3K/Akt, GSK-3β, CREB, ERK1/2, mTOR phosphorylation, blocks Tau hyperphosphorylation, prevents apoptosis, promotes survival and proliferation, enhances renal sodium and water transport, increases plasma volume and blood pressure, reduces plasma potassium and renin activity, stimulates erythropoietin expression, modulates uterine receptivity genes, and reverses PP242-induced MUC1 upregulation. Fludrocortisone can be used for the research of congenital adrenal hyperplasia, postural hypotension, and adrenal insufficiency [2] .
Cat. No.: HY-P99781
CAS No.: 1610761-46-0
Synonyms: MLN-1202
Target:
Research Areas:
Cat. No.: HY-B0673R
CAS No.: 53179-13-8
Synonyms: AMR69 (Standard)
Target:
Research Areas:
Pirfenidone (Standard) is the analytical standard of Pirfenidone. This product is intended for research and analytical applications. Pirfenidone (AMR69) is an antifibrotic agent that attenuates CCL2 and CCL12 production in fibrocyte cells. Pirfenidone has growth-inhibitory effect and reduces TGF-β2 protein levels in human glioma cell lines. Pirfenidone also has anti-inflammatory activities [2] .
Cat. No.: HY-B0673S
CAS No.: 1020719-62-3
Synonyms: AMR69-d5
Cat. No.: HY-170415
CAS No.: 1700655-93-1
Target:
Research Areas:
EGR-1 IN-3 (Compound 36) is an early growth response 1 (EGR-1)-DNA binding disruptor. EGR-1-IN-3 inhibits TNFα-induced binding of EGR-1 to DNA and expression of genes associated with inflammation (such as TSLP, IL-31, IL-6 and CCL2). EGR-1-IN-3 can be used in the study of inflammatory diseases .
Cat. No.: HY-W013675
CAS No.: 824-46-4
Target:
Research Areas:
2-Methoxyhydroquinone is a phenolic compound that reduces TNF-α-induced production of chemokine (C-C motif) ligand 2 (CCL2) with an IC50 value of 64.3 µM. 2-Methoxyhydroquinone is also a precursor in the synthesis of the Hsp90 inhibitor Geldanamycin (HY-15230) [2].
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Protocols
Targeted therapy! The Capetin Prize winning "Click Chemistry" can be used like this!Targeted therapy! The Nobel Prize winning "Click Chemistry" can be used like this!A suitable model is crucial in drug screening experiments. Organs can mimic the three-dimensional functional structure of internal organs, have similar spatial organization to corresponding organs, maintain some key characteristics, and reproduce some physiological functions. They are widely used for modeling and personalized drug screening physiological functions.2025-02-06
