Search Result

Results for "

ChE Inhibitor

" in MedChemExpress (MCE) Product Catalog:

By Targets:	Cholinesterase (ChE) (34) 5-HT Receptor (1) Aldehyde Dehydrogenase (ALDH) (1) Amyloid-β (2) Angiotensin-converting Enzyme (ACE) (1) Apoptosis (2) Bacterial (2) Calcium Channel (1) Carbonic Anhydrase (1) Chemerin Receptor (1) Drug Metabolite (1) Endogenous Metabolite (4) Environmental Pollutants (1) Fungal (2) GSK-3 (1) HDAC (1) Histamine Receptor (1) Isotope-Labeled Compounds (5) Monoamine Oxidase (3) NOD-like Receptor (NLR) (1) Reactive Oxygen Species (ROS) (1) Reference Standards (5) Tyrosinase (1)
By Research Areas:	Cancer (5) Cardiovascular Disease (5) Infection (2) Inflammation/Immunology (3) Metabolic Disease (7) Neurological Disease (29)

By Targets:

Cholinesterase (ChE) (34)

5-HT Receptor (1)

Aldehyde Dehydrogenase (ALDH) (1)

Amyloid-β (2)

Angiotensin-converting Enzyme (ACE) (1)

Apoptosis (2)

Bacterial (2)

Calcium Channel (1)

Carbonic Anhydrase (1)

Chemerin Receptor (1)

Drug Metabolite (1)

Endogenous Metabolite (4)

Environmental Pollutants (1)

Fungal (2)

GSK-3 (1)

HDAC (1)

Histamine Receptor (1)

Isotope-Labeled Compounds (5)

Monoamine Oxidase (3)

NOD-like Receptor (NLR) (1)

Reactive Oxygen Species (ROS) (1)

Reference Standards (5)

Tyrosinase (1)

By Research Areas:

Cancer (5)

Cardiovascular Disease (5)

Infection (2)

Inflammation/Immunology (3)

Metabolic Disease (7)

Neurological Disease (29)

Inhibitors & Agonists

Peptides

Natural
Products

Isotope-Labeled Compounds

Targets Recommended: Cholinesterase (ChE)

Cat. No.	Product Name	Target	Research Areas	Chemical Structure

HY-17368

Rivastigmine 1 Publications Verification ENA 713 free base; SDZ-ENA 713 free base	Cholinesterase (ChE)	Neurological Disease
Rivastigmine (ENA 713 free base) is an orally active and potent cholinesterase (ChE) inhibitor and inhibits butyrylcholinesterase (BChE) and acetylcholinesteras (AChE) with IC₅₀s of 0.037 μM , 4.15 μM, respectively. Rivastigmine can pass the blood brain barrier (BBB). Rivastigmine is a parasympathomimetic or cholinergic agent used for the research of mild to moderate dementia of the Alzheimer's type and dementia due to Parkinson's disease .

HY-138097

α-NETA Maximum Cited Publications 13 Publications Verification	Chemerin Receptor Aldehyde Dehydrogenase (ALDH) Cholinesterase (ChE) Apoptosis	Cancer
α-NETA is a potent and noncompetitive choline acetyltransferase (ChA) inhibitor with an IC₅₀ of 9 μM. α-NETA is a potent ALDH1A1 (IC₅₀=0.04 µM) and chemokine-like receptor-1 (CMKLR1) antagonist. α-NETA weakly inhibits cholinesterase (ChE; IC₅₀=84 µM) and acetylcholinesterase (AChE; IC₅₀=300 µM). α-NETA has anti-cancer activity .

HY-11017

Rivastigmine tartrate 1 Publications Verification ENA 713; SDZ-ENA 713	Cholinesterase (ChE)	Neurological Disease
Rivastigmine tartrate (ENA 713; SDZ-ENA 713) is an orally active and potent cholinesterase (ChE) inhibitor and inhibits butyrylcholinesterase (BChE) and acetylcholinesteras (AChE) with IC₅₀s of 0.037 μM, 4.15 μM, respectively. Rivastigmine tartrate can pass the blood brain barrier (BBB). Rivastigmine tartrate is a parasympathomimetic or cholinergic agent used for the research of mild to moderate dementia of the Alzheimer's type and dementia due to Parkinson's disease .

HY-B0207A

Pyridostigmine bromide 2 Publications Verification	Cholinesterase (ChE)	Cardiovascular Disease
Pyridostigmine bromide is an orally active cholinesterase (ChE) inhibitor that can be used in cardiovascular disease research .

HY-107825

Flavonol 2 Publications Verification	Endogenous Metabolite Bacterial Cholinesterase (ChE)	Cardiovascular Disease Metabolic Disease Inflammation/Immunology Cancer
Flavonol is a cholinesterase (ChE) inhibitor, with an IC₅₀ value of 120 μM and a K_i value of 74 μM. Flavonol has antioxidant, free radical-scavenging, antibacterial properties, and immune modulation functions. Flavonol inhibits the PriA helicase of Staphylococcus aureus. Flavonol can suppress the production of NO in LPS-activated RAW 264.7 cells by inhibiting the expression of the iNOS enzyme. Flavonol shows protective and analgesic effects in mice through various neuronal pathways. Flavonol can be used in research related to tumors and atherosclerosis diseases .

HY-N2419

Erythrodiol 1 Publications Verification	Endogenous Metabolite	Metabolic Disease
Erythrodiol is an olive oil component. Erythrodiol promotes Cholesterol efflux (ChE) by selectively inhibiting the degradation of ABCA1 protein. Erythrodiol is a good candidate to be further explored for therapeutic or preventive application in the context of atherosclerosis .

HY-107275

Ebeiedinone	Cholinesterase (ChE)	Neurological Disease
Ebeiedinone, a steroidal alkaloid from Fritillaria species, inhibits the bioactivity of human whole blood cholinesterase (ChE) at the concentration of 0.1 mM, with the inhibitory effects of 69.0% .

HY-B1863

Iprobenfos	Environmental Pollutants Cholinesterase (ChE) Fungal	Infection
Iprobenfos is an organophosphorus fungicide and is widely used to control the rice blast fungus. Iprobenfos can phosphorylate the -OH group on the serine residue in the active (esteratic) site of ChEs and so inhibit both AChE and BChE activity .

HY-124957

β-NETA	Cholinesterase (ChE) Apoptosis	Cancer
β-NETA is a potent and noncompetitive choline acetyltransferase (ChA; IC₅₀=76 μM) and cholinesterase (ChE; IC₅₀=40 μM) inhibitor. β-NETA weakly inhibits acetylcholinesterase (AChE; IC₅₀=1 mM) .

HY-P4281

Ovotransferrin (328-332)	Angiotensin-converting Enzyme (ACE)	Cardiovascular Disease Neurological Disease
Ovotransferrin (328-332) has a protective activity on the blood pressure by inhibiting the Angiotensin-Converting Enzyme (ACE), with the IC₅₀ of 20 μM. Ovotransferrin (328-332) fragment has an activity against Cholinesterase (ChE), implicating in Alzheimer’s diseases .

HY-17368R

Rivastigmine (Standard) ENA 713 free base(Standard); SDZ-ENA 713 free base(Standard)	Reference Standards Cholinesterase (ChE)	Neurological Disease
Rivastigmine (Standard) is the analytical standard of Rivastigmine. This product is intended for research and analytical applications. Rivastigmine (ENA 713 free base) is an orally active and potent cholinesterase (ChE) inhibitor and inhibits butyrylcholinesterase (BChE) and acetylcholinesteras (AChE) with IC₅₀s of 0.037 μM , 4.15 μM, respectively. Rivastigmine can pass the blood brain barrier (BBB). Rivastigmine is a parasympathomimetic or cholinergic agent used for the research of mild to moderate dementia of the Alzheimer's type and dementia due to Parkinson's disease .

HY-16252

Hexafluorenium dibromide Mylaxen	Cholinesterase (ChE)	Neurological Disease
Hexafluorenium dibromide (Mylaxen) is a potent cholinesterase (ChE) inhibitor with pI₅₀ value of 6.96 and K_i value of 2.4 nM for human plasma cholinesterase (ChE) .

HY-179496

ChE/GSK-3β-IN-1	GSK-3 Cholinesterase (ChE) Amyloid-β	Neurological Disease
ChE/GSK-3β-IN-1 (compound 18o) is a potent dual *ChE/GSK-3β* inhibitor. ChE/GSK-3β-IN-1 exhibits dual inhibition of AChE (IC₅₀ = 1.7 μM), butyrylcholinesterase (BChE) (IC₅₀ = 5.3 μM), and GSK-3β (IC₅₀ = 5.7 μM). ChE/GSK-3β-IN-1 inhibits Aβ1-42 self-aggregation. ChE/GSK-3β-IN-1 can be used for Alzheimer’s disease (AD) research .

HY-159482

SBN-284	Cholinesterase (ChE) NOD-like Receptor (NLR)	Neurological Disease
SBN-284 (compound 3x) is a dual inhibitor of blood-brain permeable Cholinesterases and the NLRP3 inflammasome and is effective against EeAChE, hAChE and eqBChE, the IC₅₀ values of are 0.37, 0.31, 0.29 μM respectively, and the EC₅₀ of NLRP3 inflamm is 1 μM. SBN-284 can be used in Alzheimer's disease research .

HY-149340

PD07	Cholinesterase (ChE)	Neurological Disease
PD07 is an orally active AChE inhibitor (IC₅₀: 0.29 μM for hAChE). PD07 also inhibits ChEs, BACE1 (IC₅₀: 13.42 μM), and Aβ_1–42 aggregation in in vitro. PD07 is an antioxidant, and shows DPPH inhibitory activity (IC₅₀: 26.46 μM). PD07 improves memory and cognition in Scopolamine (HY-N0296)-induced amnesia rats. PD07 can be used for research of Alzheimer’s disease .

HY-N12133

4,7-Didehydroneophysalin B	Others	Metabolic Disease
4,7-Didehydroneophysalin B is a steroid compound. 4,7-Didehydroneophysalin B can be isolated and purified from the natural Physalis alkekengi L. var. franchetii (Mast.) Makino.

HY-162061

ChEs/MAOs-IN-1	Monoamine Oxidase	Neurological Disease
ChEs/MAOs-IN-1 (Compound 4i) is a dual inhibitor of cholinesterases (ChEs) and monoamine oxidases (MAOs).ChEs/MAOs-IN-1 has IC₅₀ values of 0.048 μM, 0.89 μM, 3.58 μM, and 0.095 μM for AChE, BChE, MAO-B and MAO-B respectively. ChEs/MAOs-IN-1 can be used in the study of neurodegenerative diseases .

HY-144388

ChE/Aβ1-42-IN-1	Cholinesterase (ChE) Amyloid-β	Neurological Disease
ChE/Aβ1-42-IN-1 (compound 28) is a potent *ChE* and Aβ_1-42 aggregation inhibitor with IC₅₀s of 0.062, 0.767 and 1.227 µM for AChE, BuChE and Aβ_1-42 aggregation, respectively. ChE/β1-42-IN-1 shows excellent BBB penetration. ChE/Aβ1-42-IN-1 is a potent multi-targeted anti-Alzheimer's agent .

HY-158092

ChEs/MAOs-IN-2	Cholinesterase (ChE) Monoamine Oxidase	Neurological Disease
ChEs/MAOs-IN-2 (compound a11) is a cholinesterases and monoamine oxidases inhibitor with IC₅₀ values of 0.10, 0.20, 0.30, 0.40 µM for MAO-A, MAO-B, AChE, and BChE, respectively. ChEs/MAOs-IN-2 has the potential for the research of Alzheimer's disease .

HY-126021

Mobam	Cholinesterase (ChE)	Neurological Disease
Mobam is a insecticide against Anoplura Pediculidae. Mobam inhibits cholinesterase (ChE) levels in rats plasma, erythrocytes, and brain, suppresses the avoidance behavior in rats .

HY-10399B

(S)-Ladostigil TV-3279	Cholinesterase (ChE)	Neurological Disease
(S)-Ladostigil (TV-3279), the S-enantiomer of TV 3326 (HY-10399), is a *ChE* inhibitor with poor MAO-B inhibitory activity. (S)-Ladostigil has neuroprotective effect

HY-124104

Aldicarb sulfoxide	Drug Metabolite	Cardiovascular Disease Metabolic Disease
Aldicarb sulfoxide is a metabolite of Aldicarb. Aldicarb sulfoxide affects the glutathione-linked enzymes in CHO-K1 cells. Aldicarb sulfoxide inhibits cholinesterase (ChE) and carboxylesterase (CaE) with IC₅₀ of 10 μM for both in zebrafish .

HY-100962A

AG 99 Tyrphostin 46; Tyrphostin AG 99	Tyrosinase	Cancer
AG 99 (Tyrphostin 46), a tyrphostin derivative, is a tyrosine kinase inhibitor that increases sister chromatid exchange frequency in transformed CHO-K1 and primary CHE cells. AG 99 is promising for research of proliferative diseases .

HY-161453

BChE-IN-32	Cholinesterase (ChE)	Neurological Disease
ChE-IN-32 (compound 5d) is a potent and selective hBChE inhibitor with an IC₅₀ value of 0.109 µM. BChE-IN-32 shows cytotoxicity. BChE-IN-32 has the potential for the research of Alzheimer's disease .

HY-133776

Rivastigmine carbamate impurity 3-Nitrophenyl ethyl(methyl)carbamate	Cholinesterase (ChE)	Neurological Disease
Rivastigmine carbamate impurity (3-Nitrophenyl ethyl(methyl)carbamate) is an impurity of Rivastigmine. Rivastigmine is an orally active and potent cholinesterase (ChE) inhibitor and inhibits butyrylcholinesterase (BChE) and acetylcholinesteras (AChE) with IC₅₀s of 0.037 μM, 4.15 μM, respectively .

HY-169162

hBChE-IN-3	Carbonic Anhydrase Cholinesterase (ChE)	Neurological Disease
hBChE-IN-3 (compound 30) is a combination of carbonic anhydrase (CA) activator and cholinesterase (ChE) inhibitor with IC50 values of 7.4 and 1.9 nM for AchE and BchE, respectively. hBChE-IN-3 can be used in the study of neurodegeneration and psychiatric disorders .

HY-N2419R

Erythrodiol (Standard)	Reference Standards Endogenous Metabolite	Metabolic Disease
Erythrodiol (Standard) is the analytical standard of Erythrodiol. This product is intended for research and analytical applications. Erythrodiol is an olive oil component. Erythrodiol promotes Cholesterol efflux (ChE) by selectively inhibiting the degradation of ABCA1 protein. Erythrodiol is a good candidate to be further explored for therapeutic or preventive application in the context of atherosclerosis .

HY-124104S

Aldicarb sulfoxide-d3	Isotope-Labeled Compounds	Metabolic Disease
Aldicarb sulfoxide-d₃ is the deuterium labled Aldicarb sulfoxide (HY-124104). Aldicarb sulfoxide is a metabolite of Aldicarb. Aldicarb sulfoxide affects the glutathione-linked enzymes in CHO-K1 cells. Aldicarb sulfoxide inhibits cholinesterase (ChE) and carboxylesterase (CaE) with IC₅₀ of 10 μM for both in zebrafish .

HY-B1863R

Iprobenfos (Standard)	Reference Standards Fungal Cholinesterase (ChE)	Infection
Iprobenfos (Standard) is the analytical standard of Iprobenfos (HY-B1863). This product is intended for research and analytical applications. Iprobenfos is an organophosphorus fungicide and is widely used to control the rice blast fungus. Iprobenfos can phosphorylate the -OH group on the serine residue in the active (esteratic) site of ChEs and so inhibit both AChE and BChE activity .

HY-149817

AChE-IN-29	Cholinesterase (ChE)	Neurological Disease
AChE-IN-29, 3-OH pyrrolidine derivative, is an cholinesterase (ChE) inhibitor. AChE-IN-29 has cholinesterase inhibitory activity for hAChE, eeAChE and eqBChE with IC₅₀ values of 0.25 μM, 0.23 μM and 0.72 μM, respectively. AChE-IN-29 can be used for the research of Alzheimer's disease .

HY-149300

SB-1436	Cholinesterase (ChE)	Neurological Disease
SB-1436 is an Cholinesterase (ChE) inhibitor, inhibits acetylcholinesterase (AChE), butyrylcholinesterase (BChE) and recombinant human acetylcholinesterase (rHuAChE) with IC₅₀s of 0.176, 0.37 and 0.08 μM, respectively. SB-1436 inhibits AChE and BChE in a non-competitive manner with K_is of 0.046 and 0.115 μM, respectively. SB-1436 significantly stops the self-aggregation of Aβ, and can be used for neurological disease research .

HY-17368S1

(Rac)-Rivastigmine-d6 (Rac)-ENA 713-d6 free base; (Rac)-SDZ-ENA 713-d6 free base	Isotope-Labeled Compounds Cholinesterase (ChE)	Neurological Disease
(Rac)-Rivastigmine-d₆ is a labelled racemic Rivastigmine. Rivastigmine (ENA 713 free base) is an orally active and potent cholinesterase (ChE) inhibitor and inhibits butyrylcholinesterase (BChE) and acetylcholinesteras (AChE) with IC₅₀s of 0.037 μM , 4.15 μM, respectively. Rivastigmine can pass the blood brain barrier (BBB). Rivastigmine is a parasympathomimetic or cholinergic agent used for the research of mild to moderate dementia of the Alzheimer's type and dementia due to Parkinson's disease .

HY-17368S2

Rivastigmine-d3 hydrochloride ENA 713-d3 hydrochloride; SDZ-ENA 713-d3 hydrochloride	Cholinesterase (ChE) Isotope-Labeled Compounds	Neurological Disease
Rivastigmine-d₃ hydrochloride is deuterated labeled Rivastigmine (HY-17368). Rivastigmine (ENA 713 free base) is an orally active and potent cholinesterase (ChE) inhibitor and inhibits butyrylcholinesterase (BChE) and acetylcholinesteras (AChE) with IC₅₀s of 0.037 μM , 4.15 μM, respectively. Rivastigmine can pass the blood brain barrier (BBB). Rivastigmine is a parasympathomimetic or cholinergic agent used for the research of mild to moderate dementia of the Alzheimer's type and dementia due to Parkinson's disease .

HY-157437

AChE/BChE-IN-16	Cholinesterase (ChE) Reactive Oxygen Species (ROS)	Neurological Disease Inflammation/Immunology
AChE/BChE-IN-16 (compound C7) is a potent cholinesterase (ChE) inhibitor with IC₅₀s of 30 nM and 48 nM for human acetylcholinesterase (hAChE) and human butyrylcholinesterase (hBChE), respectively. AChE/BChE-IN-16 exhibits a remarkable capacity to safeguard PC12 cells against H₂O₂-induced apoptosis and effectively suppresses the production of reactive oxygen species (ROS) .

HY-14795

Mimopezil ZT-1	Cholinesterase (ChE)	Neurological Disease
Mimopezil (ZT-1) is an cholinesterase (ChE) inhibitor that rapidly degrades into the active metabolite Huperzine A (HY-17388) in water or aqueous organic solvents. After oral administration, Mimopezil is rapidly absorbed but has low bioavailability (0.37%) in rats. However, after metabolism, it is converted into Huperzine A, which accumulates in the blood and exhibits strong activity. Following intravenous administration, Mimopezil reaches higher blood concentrations and is also rapidly metabolized into Huperzine A .

HY-11017R

Rivastigmine tartrate (Standard) ENA 713 (Standard); SDZ-ENA 713 (Standard)	Reference Standards Cholinesterase (ChE)	Neurological Disease
Rivastigmine (tartrate) (Standard) is the analytical standard of Rivastigmine (tartrate). This product is intended for research and analytical applications. Rivastigmine tartrate (ENA 713; SDZ-ENA 713) is an orally active and potent cholinesterase (ChE) inhibitor and inhibits butyrylcholinesterase (BChE) and acetylcholinesteras (AChE) with IC₅₀s of 0.037 μM, 4.15 μM, respectively. Rivastigmine tartrate can pass the blood brain barrier (BBB). Rivastigmine tartrate is a parasympathomimetic or cholinergic agent used for the research of mild to moderate dementia of the Alzheimer's type and dementia due to Parkinson's disease .

HY-W654335

Rivastigmine-d4 tartrate	Isotope-Labeled Compounds Cholinesterase (ChE)	Neurological Disease
Rivastigmine-d₄ (tartrate) is deuterium labeled Rivastigmine (tartrate). Rivastigmine tartrate (ENA 713; SDZ-ENA 713) is an orally active and potent cholinesterase (ChE) inhibitor and inhibits butyrylcholinesterase (BChE) and acetylcholinesteras (AChE) with IC₅₀s of 0.037 μM, 4.15 μM, respectively. Rivastigmine tartrate can pass the blood brain barrier (BBB). Rivastigmine tartrate is a parasympathomimetic or cholinergic agent used for the research of mild to moderate dementia of the Alzheimer's type and dementia due to Parkinson's disease .

HY-107825R

Flavonol (Standard)	Endogenous Metabolite Bacterial Cholinesterase (ChE) Reference Standards	Cardiovascular Disease Metabolic Disease Inflammation/Immunology Cancer
Flavonol (Standard) is the analytical standard of Flavonol. This product is intended for research and analytical applications. Flavonol is a cholinesterase (ChE) inhibitor, with an IC50 value of 120 μM and a Ki value of 74 μM. Flavonol has antioxidant, free radical-scavenging, antibacterial properties, and immune modulation functions. Flavonol inhibits the PriA helicase of Staphylococcus aureus. Flavonol can suppress the production of NO in LPS-activated RAW 264.7 cells by inhibiting the expression of the iNOS enzyme. Flavonol shows protective and analgesic effects in mice through various neuronal pathways. Flavonol can be used in research related to tumors and atherosclerosis diseases .

HY-169156

HDAC6-IN-49	HDAC Monoamine Oxidase Cholinesterase (ChE) Histamine Receptor 5-HT Receptor	Neurological Disease
HDAC6-IN-49 (Compound 3) is an inhibitor for HDAC with IC₅₀ of 0.012 and 0.735 μM for HDAC6 and HDAC1. HDAC6-IN-49 also exhibits inhibitory activities against MAO-B, cholinesterase (ChE), histamine receptor (H3R) and serotonin 6 receptor (5-HT6R). HDAC6-IN-49 exhibits neuroprotective efficacy on SH-SY5Y cell. HDAC6-IN-49 improves cognitive function and locomotor ability in Drosophila Parkinson's disease models and in C. elegans Alzheimer's disease models .

HY-106869A

SM 10888	Cholinesterase (ChE)	Neurological Disease
SM 10888 is a selective and orally active cholinesterase (ChE) inhibitor. SM 10888 can increase brain acetylcholine release. SM 10888 can be used for the research of neurological disease, such as Alzheimer's disease .

HY-W654336

(S)-Rivastigmine-d4	Isotope-Labeled Compounds Cholinesterase (ChE)	Neurological Disease
(S)-Rivastigmine-d₄ is deuterium labeled Rivastigmine. Rivastigmine (ENA 713 free base) is an orally active and potent cholinesterase (ChE) inhibitor and inhibits butyrylcholinesterase (BChE) and acetylcholinesteras (AChE) with IC₅₀s of 0.037 μM , 4.15 μM, respectively. Rivastigmine can pass the blood brain barrier (BBB). Rivastigmine is a parasympathomimetic or cholinergic agent used for the research of mild to moderate dementia of the Alzheimer's type and dementia due to Parkinson's disease .

HY-180891

Multitarget AD-IN-4	Cholinesterase (ChE) Calcium Channel	Neurological Disease
Multitarget AD-IN-4 (compound IIIj) is a multitarget-directed ligand (MTDL), with the ability to simultaneously inhibit *ChE* enzymes (EeAChE IC₅₀ = 0.157 μM, eqBuChE IC₅₀ = 0.147 μM, hAChE IC₅₀ = 1.551 μM, hBuChE IC₅₀ = 2.152 μM), exhibit antioxidant activity, provide neuroprotection, and inhibit calcium channels (Ca ²⁺ channel blockade: IC₅₀ = 30.59 μM). Multitarget AD-IN-4 reverses Scopolamine (HY-N0296)-induced amnesia in a mouse model. Multitarget AD-IN-4 can be used for Alzheimer’s disease (AD) research .

Cat. No.	Product Name	Target	Research Area

HY-P4281

Ovotransferrin (328-332)	Angiotensin-converting Enzyme (ACE)	Cardiovascular Disease Neurological Disease
Ovotransferrin (328-332) has a protective activity on the blood pressure by inhibiting the Angiotensin-Converting Enzyme (ACE), with the IC₅₀ of 20 μM. Ovotransferrin (328-332) fragment has an activity against Cholinesterase (ChE), implicating in Alzheimer’s diseases .

Cat. No.	Product Name	Category	Target	Chemical Structure

HY-107825

Flavonol 2 Publications Verification	Flavonols Structural Classification Flavonoids Classification of Application Fields Metabolic Disease Endogenous metabolite Disease Research Fields Source Classification	Endogenous Metabolite Bacterial Cholinesterase (ChE)
Flavonol is a cholinesterase (ChE) inhibitor, with an IC₅₀ value of 120 μM and a K_i value of 74 μM. Flavonol has antioxidant, free radical-scavenging, antibacterial properties, and immune modulation functions. Flavonol inhibits the PriA helicase of Staphylococcus aureus. Flavonol can suppress the production of NO in LPS-activated RAW 264.7 cells by inhibiting the expression of the iNOS enzyme. Flavonol shows protective and analgesic effects in mice through various neuronal pathways. Flavonol can be used in research related to tumors and atherosclerosis diseases .

HY-N2419

Erythrodiol 1 Publications Verification	Triterpenes other families Canarium album (Lour.) Rauesch. Classification of Application Fields Terpenoids Metabolic Disease Plants Endogenous metabolite Burseraceae Disease Research Fields Source Classification	Endogenous Metabolite
Erythrodiol is an olive oil component. Erythrodiol promotes Cholesterol efflux (ChE) by selectively inhibiting the degradation of ABCA1 protein. Erythrodiol is a good candidate to be further explored for therapeutic or preventive application in the context of atherosclerosis .

HY-107275

Ebeiedinone	Alkaloids Piperidine Alkaloids Liliaceae Plants Fritillaria ussuriensis Maxim. Source Classification	Cholinesterase (ChE)
Ebeiedinone, a steroidal alkaloid from Fritillaria species, inhibits the bioactivity of human whole blood cholinesterase (ChE) at the concentration of 0.1 mM, with the inhibitory effects of 69.0% .

HY-N12133

4,7-Didehydroneophysalin B	Structural Classification Natural Products Solanaceae Plants Alkekengi officinarum Moench Source Classification	Others
4,7-Didehydroneophysalin B is a steroid compound. 4,7-Didehydroneophysalin B can be isolated and purified from the natural Physalis alkekengi L. var. franchetii (Mast.) Makino.

HY-N2419R

Erythrodiol (Standard)	Triterpenes Structural Classification other families Canarium album (Lour.) Rauesch. Terpenoids Plants Endogenous metabolite Burseraceae Source Classification	Reference Standards Endogenous Metabolite
Erythrodiol (Standard) is the analytical standard of Erythrodiol. This product is intended for research and analytical applications. Erythrodiol is an olive oil component. Erythrodiol promotes Cholesterol efflux (ChE) by selectively inhibiting the degradation of ABCA1 protein. Erythrodiol is a good candidate to be further explored for therapeutic or preventive application in the context of atherosclerosis .

HY-107825R

Flavonol (Standard)	Flavonols Structural Classification Flavonoids Endogenous metabolite Source Classification	Endogenous Metabolite Bacterial Cholinesterase (ChE) Reference Standards
Flavonol (Standard) is the analytical standard of Flavonol. This product is intended for research and analytical applications. Flavonol is a cholinesterase (ChE) inhibitor, with an IC50 value of 120 μM and a Ki value of 74 μM. Flavonol has antioxidant, free radical-scavenging, antibacterial properties, and immune modulation functions. Flavonol inhibits the PriA helicase of Staphylococcus aureus. Flavonol can suppress the production of NO in LPS-activated RAW 264.7 cells by inhibiting the expression of the iNOS enzyme. Flavonol shows protective and analgesic effects in mice through various neuronal pathways. Flavonol can be used in research related to tumors and atherosclerosis diseases .

Cat. No.	Product Name	Chemical Structure

HY-124104S

Aldicarb sulfoxide-d3
Aldicarb sulfoxide-d₃ is the deuterium labled Aldicarb sulfoxide (HY-124104). Aldicarb sulfoxide is a metabolite of Aldicarb. Aldicarb sulfoxide affects the glutathione-linked enzymes in CHO-K1 cells. Aldicarb sulfoxide inhibits cholinesterase (ChE) and carboxylesterase (CaE) with IC₅₀ of 10 μM for both in zebrafish .

HY-17368S1

(Rac)-Rivastigmine-d6

(Rac)-Rivastigmine-d₆ is a labelled racemic Rivastigmine. Rivastigmine (ENA 713 free base) is an orally active and potent cholinesterase (ChE) inhibitor and inhibits butyrylcholinesterase (BChE) and acetylcholinesteras (AChE) with IC₅₀s of 0.037 μM , 4.15 μM, respectively. Rivastigmine can pass the blood brain barrier (BBB). Rivastigmine is a parasympathomimetic or cholinergic agent used for the research of mild to moderate dementia of the Alzheimer's type and dementia due to Parkinson's disease .

HY-17368S2

Rivastigmine-d3 hydrochloride

Rivastigmine-d₃ hydrochloride is deuterated labeled Rivastigmine (HY-17368). Rivastigmine (ENA 713 free base) is an orally active and potent cholinesterase (ChE) inhibitor and inhibits butyrylcholinesterase (BChE) and acetylcholinesteras (AChE) with IC₅₀s of 0.037 μM , 4.15 μM, respectively. Rivastigmine can pass the blood brain barrier (BBB). Rivastigmine is a parasympathomimetic or cholinergic agent used for the research of mild to moderate dementia of the Alzheimer's type and dementia due to Parkinson's disease .

HY-W654335

Rivastigmine-d4 tartrate

Rivastigmine-d₄ (tartrate) is deuterium labeled Rivastigmine (tartrate). Rivastigmine tartrate (ENA 713; SDZ-ENA 713) is an orally active and potent cholinesterase (ChE) inhibitor and inhibits butyrylcholinesterase (BChE) and acetylcholinesteras (AChE) with IC₅₀s of 0.037 μM, 4.15 μM, respectively. Rivastigmine tartrate can pass the blood brain barrier (BBB). Rivastigmine tartrate is a parasympathomimetic or cholinergic agent used for the research of mild to moderate dementia of the Alzheimer's type and dementia due to Parkinson's disease .

HY-W654336

(S)-Rivastigmine-d4

(S)-Rivastigmine-d₄ is deuterium labeled Rivastigmine. Rivastigmine (ENA 713 free base) is an orally active and potent cholinesterase (ChE) inhibitor and inhibits butyrylcholinesterase (BChE) and acetylcholinesteras (AChE) with IC₅₀s of 0.037 μM , 4.15 μM, respectively. Rivastigmine can pass the blood brain barrier (BBB). Rivastigmine is a parasympathomimetic or cholinergic agent used for the research of mild to moderate dementia of the Alzheimer's type and dementia due to Parkinson's disease .

Inquiry Online

Your information is safe with us. * Required Fields.

MCE Japan Authorized Agent ナミキ商事株式会社コスモ・バイオ株式会社重松貿易株式会社
Salutation			Country or Region *
Applicant Name *			Organization Name *
Department *
Email Address *			Product Name *
Cat. No.			Requested quantity *
Phone Number *
Remarks

Inquiry Online

Inquiry Information

Product Name:
Cat. No.:
Quantity:
MCE Japan Authorized Agent:

ChE Inhibitor

Inhibitors & Agonists

Peptides

NaturalProducts

Isotope-Labeled Compounds

Natural
Products