ChE/GSK-3β-IN-1
ChE/GSK-3β-IN-1 (compound 18o) is a potent dual ChE/GSK-3β inhibitor. ChE/GSK-3β-IN-1 exhibits dual inhibition of AChE (IC50 = 1.7 μM), butyrylcholinesterase (BChE) (IC50 = 5.3 μM), and GSK-3β (IC50 = 5.7 μM). ChE/GSK-3β-IN-1 inhibits Aβ1-42 self-aggregation. ChE/GSK-3β-IN-1 can be used for Alzheimer’s disease (AD) research.
For research use only. We do not sell to patients.
- Formula: C26H30N4O2
- Molecular Weight:430.54
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Storage:
Please store the product under the recommended conditions in the Certificate of Analysis.
Biological Activity
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GSK-3β 5.7 μM (IC50) |
AChE 1.7 μM (IC50) |
BChE 5.3 μM (IC50) |
Chemical Information
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Molecular Weight 430.54
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Formula C26H30N4O2
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SMILES
O=C1CC2=C(C3=CC=CC=C3N1)NC4=C2C=C(C=C4)C(NCCCNC5CCCCC5)=O
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Shipping
Room temperature in continental US; may vary elsewhere.
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Storage
Please store the product under the recommended conditions in the Certificate of Analysis.
Purity & Documentation
References
Calculators
Concentration (start) × Volume (start) = Concentration (final) × Volume (final)