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Results for "

Chloromethyl

" in MedChemExpress (MCE) Product Catalog:

By Targets:	Amino Acid Derivatives (1) Apoptosis (1) Bacterial (3) Biochemical Assay Reagents (5) Caspase (2) CD38 (1) CDK (2) Cholecystokinin Receptor (1) CRFR (2) Drug Derivative (2) Drug Intermediate (7) Endogenous Metabolite (1) Ephrin Receptor (1) Ferroportin (1) Fluorescent Dye (3) FOXO (1) HPV (1) IKZF Family (1) Influenza Virus (1) Isotope-Labeled Compounds (7) Ligands for E3 Ligase (1) MMP (1) MOFs (2) Molecular Glues (1) PDK-1 (1) PROTAC Linkers (1) PROTACs (2) Reactive Oxygen Species (ROS) (1) Reference Standards (6) Ser/Thr Protease (4) Topoisomerase (1) Vasopressin Receptor (1) Virus Protease (1)
By Research Areas:	Cancer (10) Cardiovascular Disease (2) Infection (7) Inflammation/Immunology (4) Metabolic Disease (6) Neurological Disease (3)

By Targets:

Amino Acid Derivatives (1)

Apoptosis (1)

Bacterial (3)

Biochemical Assay Reagents (5)

Caspase (2)

CD38 (1)

CDK (2)

Cholecystokinin Receptor (1)

CRFR (2)

Drug Derivative (2)

Drug Intermediate (7)

Endogenous Metabolite (1)

Ephrin Receptor (1)

Ferroportin (1)

Fluorescent Dye (3)

FOXO (1)

HPV (1)

IKZF Family (1)

Influenza Virus (1)

Isotope-Labeled Compounds (7)

Ligands for E3 Ligase (1)

MMP (1)

MOFs (2)

Molecular Glues (1)

PDK-1 (1)

PROTAC Linkers (1)

PROTACs (2)

Reactive Oxygen Species (ROS) (1)

Reference Standards (6)

Ser/Thr Protease (4)

Topoisomerase (1)

Vasopressin Receptor (1)

Virus Protease (1)

By Research Areas:

Cancer (10)

Cardiovascular Disease (2)

Infection (7)

Inflammation/Immunology (4)

Metabolic Disease (6)

Neurological Disease (3)

Inhibitors & Agonists

Fluorescent Dyes

Biochemical Assay Reagents

Peptides

Natural
Products

Isotope-Labeled Compounds

Cat. No.	Product Name	Target	Research Areas	Chemical Structure

HY-129047C

TPCK-treated Trypsin 1 Publications Verification	Biochemical Assay Reagents Influenza Virus	Infection
TPCK-treated Trypsin is a trypsin whose activity is inhibited by tosyl phenylalanyl chloromethyl ketone. TPCK-treated Trypsin reduces autolysis and nonspecific proteolysis during experiments, exhibits stability in storage and handling. TPCK-treated trypsin can be used in proteomics research . TPCK-treated Trypsin renders the virus hemagglutinin active, which allows multicycle replication of the virus. TPCK-treated Trypsin can be used for the study of influenza virus .

HY-D1462

CellTracker Blue CMAC 5+ Cited Publications	Fluorescent Dye	Others
CellTracker Blue CMAC is a non-fluorescent cell membrane permeable dye. The chloromethyl groups of CellTracker Blue CMAC are enzymatically cleaved by intracellular glutathione (GSH) to generate a fluorescent product (blue fluorescence, Ex/Em: 360/460 nm). CellTracker Blue CMAC is suitable for long-term cell tracking (up to 72 hours) and cell proliferation studies, and can also quantify GSH levels .

HY-134124

*Glutathione ethyl* ester**	Reactive Oxygen Species (ROS)	Metabolic Disease
Glutathione ethyl ester is a cell-permeable GSH donor and provides an efficient supply of GSH to the oocyte. Glutathione ethyl ester shows positive effect on the in vitro production of embryos by enhancement of the antioxidative defense .

HY-P10272

Rusfertide PTG-300	Ferroportin	Others
Rusfertide is a peptide mimetic of natural hepcidin, which targets and degrades ferroportin, reduces serum iron and transferrin-saturation, and thus regulates the production of red blood cells. Rusfertide ameliorates the polycythemia vera, β-thalassemia and hereditary hemochromatosis .

HY-A0248A

Polymyxin B1 1 Publications Verification	Bacterial	Infection
Polymyxin B1 is a potent antimicrobial lipopeptide first derived from Bacilus polymyxa. Polymyxin B1 is the major component in Polymyxin B (HY-A0248). Polymyxin B1 can induce lysis of bacterial cells through interaction with their membranes. Polymyxin B1 has the potential for multidrug-resistant Gram-negative bacterial infections treatment .

HY-112716

*N-alpha-Tosyl-L-lysine chloromethyl* ketone hydrochloride** 1 Publications Verification	Amino Acid Derivatives	Cancer
N-alpha-Tosyl-L-lysine chloromethyl ketone (TLCK), a trypsin like protease inhibitor, sensitizes HeLa cells to Fas-mediated cell death.

HY-124379

TPCK 1 Publications Verification L-1-Tosylamido-2-phenylethyl Chloromethyl ketone; L-TPCK	Ser/Thr Protease HPV Apoptosis PDK-1	Infection Neurological Disease Inflammation/Immunology Cancer
TPCK (L-1-Tosylamido-2-phenylethyl chloromethyl ketone; L-TPCK) is an effective serine protease inhibitor and also a blocker of the PDK1/Akt pathway. TPCK can modify the E7 protein in actively keratinocyte cells. TPCK can induce cellular apoptosis, suppress tumor growth, reduce hypoxic-ischemic brain injury in rat pups, and affect vascular permeability in inflamed rats .

HY-P1108A

Astressin 2B TFA 1 Publications Verification	CRFR	Neurological Disease Inflammation/Immunology
Astressin 2B TFA is a blood-brain barrier-impermeable, highly selective CRFR2 antagonist (rCRFR2, IC₅₀=0.57 nM). Astressin 2B TFA blocks the protective effects mediated by CRFR2, thereby exacerbating indomethacin (HY-14397)-induced hemorrhagic intestinal injury in rats. Astressin 2B TFA reverses the protective effects of Urocortin 1 against intestinal hypermotility, bacterial invasion and upregulation of inflammatory mediators. Astressin 2B TFA also blocks the anxiogenic effect of Urocortin 2 and attenuates stress-induced anxiety-related behaviors. In the Clostridioides difficile toxin A (C. difficile toxin A)-mediated enteritis model, Astressin 2B TFA mimics the phenotype of CRFR2-deficient mice, significantly exacerbating intestinal epithelial damage, edema, neutrophil migration and the expression of multiple proinflammatory cytokines. Astressin 2B TFA is an important tool molecule for investigating the intestinal protective mechanisms of CRFR2 .

HY-P1108

Astressin 2B 1 Publications Verification	CRFR	Neurological Disease Inflammation/Immunology
Astressin 2B is a blood-brain barrier-impermeable, highly selective CRFR2 antagonist (rCRFR2, IC₅₀=0.57 nM). Astressin 2B blocks the protective effects mediated by CRFR2, thereby exacerbating indomethacin (HY-14397)-induced hemorrhagic intestinal injury in rats. Astressin 2B reverses the protective effects of Urocortin 1 against intestinal hypermotility, bacterial invasion and upregulation of inflammatory mediators. Astressin 2B also blocks the anxiogenic effect of Urocortin 2 and attenuates stress-induced anxiety-related behaviors. In the Clostridioides difficile toxin A (C. difficile toxin A)-mediated enteritis model, Astressin 2B mimics the phenotype of CRFR2-deficient mice, significantly exacerbating intestinal epithelial damage, edema, neutrophil migration and the expression of multiple proinflammatory cytokines. Astressin 2B is an important tool molecule for investigating the intestinal protective mechanisms of CRFR2 .

HY-43384

Chloromethyl methyl carbonate Tenofovir Impurity 66	Drug Intermediate	Others
Chloromethyl methyl carbonate (Tenofovir Impurity 66) is a drug intermediate for synthesis of various active compounds.

HY-137038

*N-alpha-Tosyl-Lys chloromethyl* ketone hydrochloride** TLCK hydrochloride	Caspase Ser/Thr Protease FOXO	Cardiovascular Disease Cancer
N-alpha-Tosyl-Lys chloromethyl ketone hydrochloride (TLCK hydrochloride) is a Serine protease inhibitor with an IC₅₀ of 12.0 μM against Caspase-3, 54.5 μM against Caspase-6, and 19.3 μM against Caspase-7. It inhibits thrombin-induced nuclear translocation of FOXO1. N-alpha-Tosyl-Lys chloromethyl ketone hydrochloride can be used in research related to leukemia and cardiovascular diseases .

HY-122542A

PPACK dihydrochloride 2 Publications Verification Pebac; D-Phenylalanyl-prolyl-arginyl Chloromethyl Ketone; D-Phe-Pro-Arg-CH2Cl	Ligands for E3 Ligase Molecular Glues IKZF Family	Cardiovascular Disease
PPACK dihydrochloride is an orally active, selective molecular glue degrader targeting IKZF2. Through a molecular glue mechanism, PPACK dihydrochloride binds to CRBN, recruits IKZF2 to form a ternary complex, and promotes its ubiquitination and proteasomal degradation. This further converts inhibitory regulatory T cells (T_reg) into effector-like T cells, enhances CD8 ⁺ T cell responses, and modulates the T_eff:T_reg balance. PPACK dihydrochloride also increases the production of the inflammatory cytokine IL-2 and reduces the suppressive activity of T_reg. PPACK dihydrochloride can be used in cancer immunotherapy research, and exhibits a synergistic effect when combined with immune checkpoint inhibitors such as anti-PD1 .

HY-P10579

123B9 1 Publications Verification	Ephrin Receptor	Cancer
123B9, a tumor-homing agent, is a potent and selective EphA2 agonist with a K_d value of 4.0 μM. 123B9 selectively targets the EphA2 tyrosine kinase receptor ligand-binding domain. 123B9 does not appreciably inhibit the ligand binding domains of the most closely related EphA3 and EphA4 receptors .

HY-76779

*4-(Chloromethyl)-7-hydroxycoumarin*	Drug Derivative	Cancer
4-(Chloromethyl)-7-hydroxycoumarin (compound 4) is a hydroxycoumarin derivative with potent antioxidant effect and high hydroxyl radical-scavenging property. 4-(Chloromethyl)-7-hydroxycoumarin contains a methyl group and a chlorine group in the heterocyclic ring. A series of coumarins incorporating hydroxy-, chloro- and/or chloromethyl-moieties has been investigated as potent inhibitors of the zinc enzyme carbonic anhydrase, expecially tumor-associated isoforms CA IX and XII .

HY-DY1041

CellTracker Blue CMAC (solution)	Fluorescent Dye	Others
CellTracker Blue CMAC (solution) is a non-fluorescent cell membrane permeable dye. The chloromethyl groups of CellTracker Blue CMAC are enzymatically cleaved by intracellular glutathione (GSH) to generate a fluorescent product (blue fluorescence, Ex/Em: 360/460 nm). CellTracker Blue CMAC is suitable for long-term cell tracking (up to 72 hours) and cell proliferation studies, and can also quantify GSH levels . Solvent and concentration: DMSO: 10 mM

HY-P10143

MMP-2/MMP-9 Substrate Ac-Pro-Leu-Gly-[(S)-2-mercapto-4-methyl-pentanoyl]-Leu-Gly-OEt	MMP	Others
MMP-2/MMP-9 Substrate (Ac-Pro-Leu-Gly-[(S)-2-mercapto-4-methyl-pentanoyl]-Leu-Gly-OEt) is a synthetic chromogenic polypeptide substrate whose core structure mimics the cleavage sites of MMP-2 and MMP-9 (gelatinase A and B) in collagen. After being hydrolyzed by collagenase, MMP-2/MMP-9 Substrate reacts with 4,4'-dithiodipyridine or Ellman's Reagent via its thiol fragment to produce a product with ultraviolet absorption properties .

HY-A0248AS

Polymyxin B1-d7 TFA	Isotope-Labeled Compounds Bacterial	Infection
Polymyxin B1-d₇ TFA is the deuterium labeled Polymyxin B1 TFA (HY-A0248A). Polymyxin B1 is a potent antimicrobial lipopeptide first derived from Bacilus polymyxa. Polymyxin B1 is the major component in Polymyxin B (HY-A0248). Polymyxin B1 can induce lysis of bacterial cells through interaction with their membranes. Polymyxin B1 has the potential for multidrug-resistant Gram-negative bacterial infections treatment .

HY-W013510

*2-(Chloromethyl)-3,4-dimethoxypyridine hydrochloride*	Biochemical Assay Reagents	Others
2-(Chloromethyl)-3,4-dimethoxypyridine hydrochloride is a biochemical reagent that can be used as a biological material or organic compound for life science related research.

HY-42850

*5-Chloromethyl-1-propyl-1H-imidazole hydrochloride*	Drug Intermediate	Others
5-Chloromethyl-1-propyl-1H-imidazole hydrochloride is a drug intermediate for synthesis of various active compounds.

HY-P10563

Noraramtide BHV-1100	CD38	Cancer
Noraramtide (BHV-1100) is an antibody recruitment molecule. Noraramtide can specifically bind to CD38 molecules to recruit natural killer (NK) cells. Noraramtide enhances the ability of NK cells to kill tumor cells through antibody-dependent cellular cytotoxicity (ADCC). This mechanism allows NK cells to more effectively recognize and eliminate tumor cells while avoiding mutual killing between NK cells. Noraramtide can be used for the study of autologous cancer immunity .

HY-I0167

*1-(2-(4-(Chloromethyl)phenoxy)ethyl)azepane hydrochloride*	Drug Intermediate	Others
1-(2-(4-(Chloromethyl)phenoxy)ethyl)azepane hydrochloride is a drug intermediate for synthesis of various active compounds.

HY-23565

*(R)-1,4-Dibenzyl-2-(chloromethyl)piperazine*	Drug Intermediate	Others
(R)-1,4-Dibenzyl-2-(chloromethyl)piperazine is a drug intermediate for synthesis of various active compounds.

HY-P10095

D-Val-Phe-Lys-CMK D-Val-Phe-Lys Chloromethyl ketone	Ser/Thr Protease	Metabolic Disease
D-Val-Phe-Lys-CMK (D-Val-Phe-Lys Chloromethyl ketone) can inhibit plasmin activity .

HY-P10095A

D-Val-Phe-Lys-CMK diTFA D-Val-Phe-Lys Chloromethyl ketone diTFA	Ser/Thr Protease	Metabolic Disease
D-Val-Phe-Lys-CMK (D-Val-Phe-Lys Chloromethyl ketone) diTFA can inhibit plasmin activity .

HY-P3066

SKF 100398 d(CH2)5Tyr(Et)VAVP	Vasopressin Receptor	Metabolic Disease
SKF 100398 (d(CH2)5Tyr(Et)VAVP), an arginine vasopressin (AVP) analogue, is a specific antagonist of the antidiuretic effect of exogenous and endogenous AVP .

HY-52102

*2-(Chloromethyl)pyrimidine hydrochloride*	Drug Intermediate	Others
2-(Chloromethyl)pyrimidine hydrochloride is a synthetic intermediate useful for pharmaceutical synthesis.

HY-W007502

*2-(Chloromethyl)pyridine hydrochloride* Picolyl chloride hydrochloride	Biochemical Assay Reagents Drug Intermediate	Others
2-(Chloromethyl)pyridine (Picolyl chloride) hydrochloride is an alkylating agent that can be used in organic synthesis reactions .

HY-Z2475

Tenofovir impurity 54 Chloromethyl Propyl Carbonate	Drug Intermediate	Others
Tenofovir Impurity 54 (Chloromethyl Propyl Carbonate) is an impurity of Tenofovir (HY-13910).

HY-W587507

1,2-Dilauroyl-3-chloropropanediol 1,1′-[1-(Chloromethyl)-1,2-ethanediyl] didodecanoate	Others	Metabolic Disease
1,2-Dilauroyl-3-chloropropanediol (1,1′-[1-(Chloromethyl)-1,2-ethanediyl] didodecanoate) is an ester product.

HY-P10828

MAPI	Virus Protease	Infection Inflammation/Immunology
MAPI is a polypeptide irreversible 3C cysteine protease (SV3CP) inhibitor. MAPI inhibits SV3CP by covalently binding its C-terminal Michael-acceptor extension to the active site thiol of SV3CP Cys 139. MAPI is promising for research of noroviruses infection .

HY-W015577R

Chloromethyl isopropyl carbonate (Standard)	Reference Standards
Chloromethyl isopropyl carbonate (Standard) is the analytical standard of Chloromethyl isopropyl carbonate. This product is intended for research and analytical applications.

HY-W704178

*N-Chloromethyl* citalopram-d6 chloride**	Isotope-Labeled Compounds	Others
N-Chloromethyl citalopram-d₆ chloride is the deuterium labeled N-Chloromethyl citalopram chloride.

HY-156723

*9-Chloromethyl-10-hydroxy-11-F-Camptothecin*	Topoisomerase	Cancer
9-Chloromethyl-10-hydroxy-11-F-Camptothecin is a novel camptothecin derivatives. 9-Chloromethyl-10-hydroxy-11-F-Camptothecin is a DNA topoisomerase I (Topo I) inhibitor, can be used in anticancer research .

HY-W613504

*4-(Chloromethyl)phenylacetic Acid*	PROTAC Linkers	Cancer
4-(Chloromethyl)phenylacetic Acid is a PROTAC linker that can be used in the synthesis of PROTACs.

HY-W010311R

*1-(Chloromethyl)-4-methylbenzene (Standard)* α-Chloro-p-xylene (Standard)	Reference Standards
1-(Chloromethyl)-4-methylbenzene (Standard) is the analytical standard of 1-(Chloromethyl)-4-methylbenzene. This product is intended for research and analytical applications.

HY-W016753R

*1,3-Bis(chloromethyl)benzene (Standard)*	Reference Standards
1,3-Bis(chloromethyl)benzene (Standard) is the analytical standard of 1,3-Bis(chloromethyl)benzene. This product is intended for research and analytical applications.

HY-W711764

*1-Chloro-2-(chloromethyl)benzene-3,4,5,6-d4*	Isotope-Labeled Compounds	Others
1-Chloro-2-(chloromethyl)benzene-3,4,5,6-d₄ is the deuterium labeled 1-Chloro-2-(chloromethyl)benzene (HY-W013647).

HY-W654074

1,2-Dilauroyl-3-chloropropanediol-d5 1,1′-[1-(Chloromethyl)-1,2-ethanediyl] didodecanoate-d₅	Isotope-Labeled Compounds Biochemical Assay Reagents	Metabolic Disease
1,2-Dilauroyl-3-chloropropanediol-d₅ (1,1′-[1-(Chloromethyl)-1,2-ethanediyl] didodecanoate-d₅) is the deuterium labeled 1,2-Dilauroyl-3-chloropropanediol (HY-W587507). 1,2-Dilauroyl-3-chloropropanediol (1,1′-[1-(Chloromethyl)-1,2-ethanediyl] didodecanoate) is an ester product.

HY-D1278

*4-(5)-(((4-ChloroMethyl)Benzoyl)AMino)TetraMethylrhodaMine*	Fluorescent Dye	Others
4-(5)-(((4-ChloroMethyl)Benzoyl)AMino)TetraMethylrhodaMine is a multifunctional dye. Dyes are important tools in biological experiments. They can help researchers observe and analyze cell structures, track biomolecules, evaluate cell functions, distinguish cell types, detect biomolecules, study tissue pathology and monitor microorganisms. Their applications range from basic scientific research to clinical A wide range of diagnostics. Dyes are also widely used in traditional fields such as textile dyeing, as well as in emerging fields such as functional textile processing, food pigments and dye-sensitized solar cells.

HY-Z2475R

Tenofovir impurity 54 (Standard)	Reference Standards
chloromethyl propyl carbonate (Tenofovir Impurity） (Standard) is the analytical standard of chloromethyl propyl carbonate (Tenofovir Impurity）. This product is intended for research and analytical applications.

HY-P2592

Ro 23-7014	Cholecystokinin Receptor	Others
Ro 23-7014 is an appetite suppressant. Ro 23-7014 is an analog of cholecystokinin (CCK-7) .

HY-125628

Kahalalide A	Endogenous Metabolite	Infection
Kahalalide A is an anti-mycobacterial compound with antimicrobial activity. Kahalalide A is derived from the marine mollusk Elysia rufescens. Kahalalide A has attracted extensive attention in natural product research due to its potential medicinal value .

HY-I0482R

*2-(Chloromethyl)-4-methylquinazoline (Standard)*	Reference Standards
2-(Chloromethyl)-4-methylquinazoline (Standard) is the analytical standard of 2-(Chloromethyl)-4-methylquinazoline. This product is intended for research and analytical applications.

HY-W742282

*4-(Chloromethyl)-2,5-oxazolidinedione-d3*	Isotope-Labeled Compounds	Others
4-(Chloromethyl)-2,5-oxazolidinedione-d₃ is the deuterium labeled 4-(Chloromethyl)oxazolidine-2,5-dione (HY-W703708).

HY-W856148

*4'-(Chloromethyl)-4,2':6',4''-terpyridine*	MOFs	Others
4'-(Chloromethyl)-4,2':6',4''-terpyridine is a metal-organic framework (MOF).

HY-W856149

*4'-(Chloromethyl)-4,3':5',4''-terpyridine*	MOFs	Others
4'-(Chloromethyl)-4,3':5',4''-terpyridine is a metal-organic framework (MOF).

HY-W540356

*3,6-Bis(chloromethyl)durene*	Biochemical Assay Reagents
3, 6-BIS (chloromethyl)durene is a biochemical reagent .

HY-W613766S

Ethyl 2-[4-(chloromethyl)phenyl]propanoater-d3	Isotope-Labeled Compounds	Others
Ethyl 2-[4-(chloromethyl)phenyl]propanoater-d₃ is the deuterium labeled Ethyl 2-[4-(chloromethyl)phenyl]propanoater.

HY-W040762R

*2,4-Dichloro-1-(chloromethyl)benzene (Standard)*	Reference Standards
2,4-Dichloro-1-(chloromethyl)benzene (Standard) is the analytical standard of 2,4-Dichloro-1-(chloromethyl)benzene. This product is intended for research and analytical applications.

HY-W319189

*2-(Chloromethyl)-3-(2-methylphenyl)quinazolin-4(3H)-one*	Drug Derivative	Others
2-(Chloromethyl)-3-(2-methylphenyl)quinazolin-4(3H)-one is a quinazolinone.

Cat. No.	Product Name	Type

HY-D1462

CellTracker Blue CMAC

5+ Cited Publications

Fluorescent Dyes

CellTracker Blue CMAC is a non-fluorescent cell membrane permeable dye. The chloromethyl groups of CellTracker Blue CMAC are enzymatically cleaved by intracellular glutathione (GSH) to generate a fluorescent product (blue fluorescence, Ex/Em: 360/460 nm). CellTracker Blue CMAC is suitable for long-term cell tracking (up to 72 hours) and cell proliferation studies, and can also quantify GSH levels .

HY-DY1041

CellTracker Blue CMAC (solution)

Fluorescent Dyes

CellTracker Blue CMAC (solution) is a non-fluorescent cell membrane permeable dye. The chloromethyl groups of CellTracker Blue CMAC are enzymatically cleaved by intracellular glutathione (GSH) to generate a fluorescent product (blue fluorescence, Ex/Em: 360/460 nm). CellTracker Blue CMAC is suitable for long-term cell tracking (up to 72 hours) and cell proliferation studies, and can also quantify GSH levels .
Solvent and concentration: DMSO: 10 mM

HY-D1278

4-(5)-(((4-ChloroMethyl)Benzoyl)AMino)TetraMethylrhodaMine

Fluorescent Dyes

4-(5)-(((4-ChloroMethyl)Benzoyl)AMino)TetraMethylrhodaMine is a multifunctional dye. Dyes are important tools in biological experiments. They can help researchers observe and analyze cell structures, track biomolecules, evaluate cell functions, distinguish cell types, detect biomolecules, study tissue pathology and monitor microorganisms. Their applications range from basic scientific research to clinical A wide range of diagnostics. Dyes are also widely used in traditional fields such as textile dyeing, as well as in emerging fields such as functional textile processing, food pigments and dye-sensitized solar cells.

Cat. No.	Product Name	Target	Research Area

HY-134124

*Glutathione ethyl* ester**	Reactive Oxygen Species (ROS)	Metabolic Disease
Glutathione ethyl ester is a cell-permeable GSH donor and provides an efficient supply of GSH to the oocyte. Glutathione ethyl ester shows positive effect on the in vitro production of embryos by enhancement of the antioxidative defense .

HY-P10272

Rusfertide PTG-300	Ferroportin	Others
Rusfertide is a peptide mimetic of natural hepcidin, which targets and degrades ferroportin, reduces serum iron and transferrin-saturation, and thus regulates the production of red blood cells. Rusfertide ameliorates the polycythemia vera, β-thalassemia and hereditary hemochromatosis .

HY-A0248A

Polymyxin B1 1 Publications Verification	Bacterial	Infection
Polymyxin B1 is a potent antimicrobial lipopeptide first derived from Bacilus polymyxa. Polymyxin B1 is the major component in Polymyxin B (HY-A0248). Polymyxin B1 can induce lysis of bacterial cells through interaction with their membranes. Polymyxin B1 has the potential for multidrug-resistant Gram-negative bacterial infections treatment .

HY-P1108A

Astressin 2B TFA 1 Publications Verification	CRFR	Neurological Disease Inflammation/Immunology
Astressin 2B TFA is a blood-brain barrier-impermeable, highly selective CRFR2 antagonist (rCRFR2, IC₅₀=0.57 nM). Astressin 2B TFA blocks the protective effects mediated by CRFR2, thereby exacerbating indomethacin (HY-14397)-induced hemorrhagic intestinal injury in rats. Astressin 2B TFA reverses the protective effects of Urocortin 1 against intestinal hypermotility, bacterial invasion and upregulation of inflammatory mediators. Astressin 2B TFA also blocks the anxiogenic effect of Urocortin 2 and attenuates stress-induced anxiety-related behaviors. In the Clostridioides difficile toxin A (C. difficile toxin A)-mediated enteritis model, Astressin 2B TFA mimics the phenotype of CRFR2-deficient mice, significantly exacerbating intestinal epithelial damage, edema, neutrophil migration and the expression of multiple proinflammatory cytokines. Astressin 2B TFA is an important tool molecule for investigating the intestinal protective mechanisms of CRFR2 .

HY-P1108

Astressin 2B 1 Publications Verification	CRFR	Neurological Disease Inflammation/Immunology
Astressin 2B is a blood-brain barrier-impermeable, highly selective CRFR2 antagonist (rCRFR2, IC₅₀=0.57 nM). Astressin 2B blocks the protective effects mediated by CRFR2, thereby exacerbating indomethacin (HY-14397)-induced hemorrhagic intestinal injury in rats. Astressin 2B reverses the protective effects of Urocortin 1 against intestinal hypermotility, bacterial invasion and upregulation of inflammatory mediators. Astressin 2B also blocks the anxiogenic effect of Urocortin 2 and attenuates stress-induced anxiety-related behaviors. In the Clostridioides difficile toxin A (C. difficile toxin A)-mediated enteritis model, Astressin 2B mimics the phenotype of CRFR2-deficient mice, significantly exacerbating intestinal epithelial damage, edema, neutrophil migration and the expression of multiple proinflammatory cytokines. Astressin 2B is an important tool molecule for investigating the intestinal protective mechanisms of CRFR2 .

HY-P10579

123B9 1 Publications Verification	Ephrin Receptor	Cancer
123B9, a tumor-homing agent, is a potent and selective EphA2 agonist with a K_d value of 4.0 μM. 123B9 selectively targets the EphA2 tyrosine kinase receptor ligand-binding domain. 123B9 does not appreciably inhibit the ligand binding domains of the most closely related EphA3 and EphA4 receptors .

HY-P10143

MMP-2/MMP-9 Substrate Ac-Pro-Leu-Gly-[(S)-2-mercapto-4-methyl-pentanoyl]-Leu-Gly-OEt	MMP	Others
MMP-2/MMP-9 Substrate (Ac-Pro-Leu-Gly-[(S)-2-mercapto-4-methyl-pentanoyl]-Leu-Gly-OEt) is a synthetic chromogenic polypeptide substrate whose core structure mimics the cleavage sites of MMP-2 and MMP-9 (gelatinase A and B) in collagen. After being hydrolyzed by collagenase, MMP-2/MMP-9 Substrate reacts with 4,4'-dithiodipyridine or Ellman's Reagent via its thiol fragment to produce a product with ultraviolet absorption properties .

HY-A0248AS

Polymyxin B1-d7 TFA	Isotope-Labeled Compounds Bacterial	Infection
Polymyxin B1-d₇ TFA is the deuterium labeled Polymyxin B1 TFA (HY-A0248A). Polymyxin B1 is a potent antimicrobial lipopeptide first derived from Bacilus polymyxa. Polymyxin B1 is the major component in Polymyxin B (HY-A0248). Polymyxin B1 can induce lysis of bacterial cells through interaction with their membranes. Polymyxin B1 has the potential for multidrug-resistant Gram-negative bacterial infections treatment .

HY-P10563

Noraramtide BHV-1100	CD38	Cancer
Noraramtide (BHV-1100) is an antibody recruitment molecule. Noraramtide can specifically bind to CD38 molecules to recruit natural killer (NK) cells. Noraramtide enhances the ability of NK cells to kill tumor cells through antibody-dependent cellular cytotoxicity (ADCC). This mechanism allows NK cells to more effectively recognize and eliminate tumor cells while avoiding mutual killing between NK cells. Noraramtide can be used for the study of autologous cancer immunity .

HY-P10095

D-Val-Phe-Lys-CMK D-Val-Phe-Lys Chloromethyl ketone	Ser/Thr Protease	Metabolic Disease
D-Val-Phe-Lys-CMK (D-Val-Phe-Lys Chloromethyl ketone) can inhibit plasmin activity .

HY-P10095A

D-Val-Phe-Lys-CMK diTFA D-Val-Phe-Lys Chloromethyl ketone diTFA	Ser/Thr Protease	Metabolic Disease
D-Val-Phe-Lys-CMK (D-Val-Phe-Lys Chloromethyl ketone) diTFA can inhibit plasmin activity .

HY-P3066

SKF 100398 d(CH2)5Tyr(Et)VAVP	Vasopressin Receptor	Metabolic Disease
SKF 100398 (d(CH2)5Tyr(Et)VAVP), an arginine vasopressin (AVP) analogue, is a specific antagonist of the antidiuretic effect of exogenous and endogenous AVP .

HY-P10828

MAPI	Virus Protease	Infection Inflammation/Immunology
MAPI is a polypeptide irreversible 3C cysteine protease (SV3CP) inhibitor. MAPI inhibits SV3CP by covalently binding its C-terminal Michael-acceptor extension to the active site thiol of SV3CP Cys 139. MAPI is promising for research of noroviruses infection .

HY-P4756

*N-(2-Carbamoyl-ethyl)-Val-Leu-anilide*	Peptides	Others
N-(2-Carbamoyl-ethyl)-Val-Leu-anilide is a polypeptide that can be found by peptide screening. Peptide screening is a research tool that pools active peptides primarily by immunoassay. Peptide screening can be used for protein interaction, functional analysis, epitope screening, especially in the field of agent research and development .

HY-P2592

Ro 23-7014	Cholecystokinin Receptor	Others
Ro 23-7014 is an appetite suppressant. Ro 23-7014 is an analog of cholecystokinin (CCK-7) .

HY-125628

Kahalalide A	Endogenous Metabolite	Infection
Kahalalide A is an anti-mycobacterial compound with antimicrobial activity. Kahalalide A is derived from the marine mollusk Elysia rufescens. Kahalalide A has attracted extensive attention in natural product research due to its potential medicinal value .

HY-A0248AS1

Polymyxin B1-D-Leu-d7 TFA	Isotope-Labeled Compounds Bacterial	Infection
Polymyxin B1-D-Leu-d₇ TFA is the deuterium labeled Polymyxin B1 (HY-A0248A). Polymyxin B1 is a potent antimicrobial lipopeptide first derived from Bacilus polymyxa. Polymyxin B1 is the major component in Polymyxin B (HY-A0248). Polymyxin B1 can induce lysis of bacterial cells through interaction with their membranes. Polymyxin B1 has the potential for multidrug-resistant Gram-negative bacterial infections treatment .

Cat. No.	Product Name	Category	Target	Chemical Structure

HY-A0248A

Polymyxin B1 1 Publications Verification	Infection Microorganisms Classification of Application Fields Antibiotics Antibacterial Disease Research Disease Research Fields Other Antibiotics Source Classification	Bacterial
Polymyxin B1 is a potent antimicrobial lipopeptide first derived from Bacilus polymyxa. Polymyxin B1 is the major component in Polymyxin B (HY-A0248). Polymyxin B1 can induce lysis of bacterial cells through interaction with their membranes. Polymyxin B1 has the potential for multidrug-resistant Gram-negative bacterial infections treatment .

HY-A0248AS

Polymyxin B1-d7 TFA	Structural Classification Microorganisms Antibiotics Antibacterial Disease Research Other Antibiotics Source Classification	Isotope-Labeled Compounds Bacterial
Polymyxin B1-d₇ TFA is the deuterium labeled Polymyxin B1 TFA (HY-A0248A). Polymyxin B1 is a potent antimicrobial lipopeptide first derived from Bacilus polymyxa. Polymyxin B1 is the major component in Polymyxin B (HY-A0248). Polymyxin B1 can induce lysis of bacterial cells through interaction with their membranes. Polymyxin B1 has the potential for multidrug-resistant Gram-negative bacterial infections treatment .

HY-A0248AS1

Polymyxin B1-D-Leu-d7 TFA	Structural Classification Microorganisms Antibiotics Antibacterial Disease Research Other Antibiotics Source Classification	Isotope-Labeled Compounds Bacterial
Polymyxin B1-D-Leu-d₇ TFA is the deuterium labeled Polymyxin B1 (HY-A0248A). Polymyxin B1 is a potent antimicrobial lipopeptide first derived from Bacilus polymyxa. Polymyxin B1 is the major component in Polymyxin B (HY-A0248). Polymyxin B1 can induce lysis of bacterial cells through interaction with their membranes. Polymyxin B1 has the potential for multidrug-resistant Gram-negative bacterial infections treatment .

Cat. No.	Product Name	Chemical Structure

HY-A0248AS

Polymyxin B1-d7 TFA

Polymyxin B1-d₇ TFA is the deuterium labeled Polymyxin B1 TFA (HY-A0248A). Polymyxin B1 is a potent antimicrobial lipopeptide first derived from Bacilus polymyxa. Polymyxin B1 is the major component in Polymyxin B (HY-A0248). Polymyxin B1 can induce lysis of bacterial cells through interaction with their membranes. Polymyxin B1 has the potential for multidrug-resistant Gram-negative bacterial infections treatment .

HY-W704178

*N-Chloromethyl* citalopram-d6 chloride**
N-Chloromethyl citalopram-d₆ chloride is the deuterium labeled N-Chloromethyl citalopram chloride.

HY-W711764

*1-Chloro-2-(chloromethyl)benzene-3,4,5,6-d4*
1-Chloro-2-(chloromethyl)benzene-3,4,5,6-d₄ is the deuterium labeled 1-Chloro-2-(chloromethyl)benzene (HY-W013647).

HY-W654074

1,2-Dilauroyl-3-chloropropanediol-d5
1,2-Dilauroyl-3-chloropropanediol-d₅ (1,1′-[1-(Chloromethyl)-1,2-ethanediyl] didodecanoate-d₅) is the deuterium labeled 1,2-Dilauroyl-3-chloropropanediol (HY-W587507). 1,2-Dilauroyl-3-chloropropanediol (1,1′-[1-(Chloromethyl)-1,2-ethanediyl] didodecanoate) is an ester product.

HY-W742282

*4-(Chloromethyl)-2,5-oxazolidinedione-d3*
4-(Chloromethyl)-2,5-oxazolidinedione-d₃ is the deuterium labeled 4-(Chloromethyl)oxazolidine-2,5-dione (HY-W703708).

HY-W613766S

Ethyl 2-[4-(chloromethyl)phenyl]propanoater-d3
Ethyl 2-[4-(chloromethyl)phenyl]propanoater-d₃ is the deuterium labeled Ethyl 2-[4-(chloromethyl)phenyl]propanoater.

HY-A0248AS1

Polymyxin B1-D-Leu-d7 TFA

Polymyxin B1-D-Leu-d₇ TFA is the deuterium labeled Polymyxin B1 (HY-A0248A). Polymyxin B1 is a potent antimicrobial lipopeptide first derived from Bacilus polymyxa. Polymyxin B1 is the major component in Polymyxin B (HY-A0248). Polymyxin B1 can induce lysis of bacterial cells through interaction with their membranes. Polymyxin B1 has the potential for multidrug-resistant Gram-negative bacterial infections treatment .

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