113 Results for "

Complication

" in MedChemExpress (MCE) Product Catalog:
Products (113)

113 Results for "Complication" in MCE Product Catalog:

28
Fosribnicotinamide
Fosribnicotinamide
0 Images
28 Publications Verification
Cat. No.: HY-F0004
CAS No.: 1094-61-7
Synonyms: β-Nicotinamide mononucleotide; β-NM; NMN
Category:  

Neurological Disease Other disease Anti-aging Endogenous metabolite Human Gut Microbiota Metabolites Microorganisms Ketones, Aldehydes, Acids Disease markers Disease Research Fields Cancer

Target:  

Endogenous Metabolite

Fosribnicotinamide (β-nicotinamide mononucleotide) is a product of the nicotinamide phosphoribosyltransferase (NAMPT) reaction and a key NAD + intermediate. The pharmacological activities of Fosribnicotinamide include its role in cellular biochemical functions, cardioprotection, diabetes, Alzheimer's disease, and complications associated with obesity .
20
Salvianolic acid B
Salvianolic acid B
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20 Cited Publications
Cat. No.: HY-N1362
CAS No.: 121521-90-2
Synonyms: Lithospermic acid B
Category:  

Cardiovascular Disease Labiatae Samanea saman (Jacq.) Merr. Phenols Polyphenols Plants Disease Research Fields

Target:  

Autophagy

Salvianolic acid B is an active ingredient of Salvia miltiorrhiza, which has been widely applied in China for the management of various microcirculation-related disorders, such as cardiovascular disease, cerebrovascular disease, and diabetic vascular complication.
6
Phenelzine sulfate
Phenelzine sulfate
0 Images
6 Cited Publications
Cat. No.: HY-B1018A
CAS No.: 156-51-4
Target:  

Monoamine Oxidase GABA Receptor Histone Demethylase

Research Areas:  

Cardiovascular Disease Neurological Disease Metabolic Disease Inflammation/Immunology Cancer

Phenelzine sulfate, an antidepressant agent, is an irreversible and orally active monoamine oxidase (MAO-A and MAO-B) inhibitor. Phenelzine sulfate inhibits GABA transaminase and primary amine oxidase (PrAO), and sequester reactive aldehydes. Phenelzine sulfate also inhibits LSD1 (Ki: 5.6 μM) and suppresses oxidative stress and lipogenesis. Phenelzine sulfate elevates neurotransmitters (serotonin, norepinephrine, dopamine). Phenelzine sulfate is studied in neurological, metabolic and cancer diseases for depression and anxiety disorders, stroke, spinal cord injury, traumatic brain injury, multiple sclerosis, Parkinson’s disease, Alzheimer’s disease, inflammatory pain, obesity and prostate cancer .
5
O-304
O-304
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5 Cited Publications
Cat. No.: HY-112233
CAS No.: 1261289-04-6
Purity:  99.50%
Target:  

AMPK

Research Areas:  

Cardiovascular Disease Metabolic Disease

O-304 is a first-in-class, orally available pan-AMPK activator, which increases AMPK activity by suppressing the dephosphorylation of pAMPK. O-304 exhibits a great potential as a agent to treat type 2 diabetes (T2D) and associated cardiovascular complications .
3
Hirudin
Hirudin
0 Images
3 Cited Publications
Cat. No.: HY-P2813
CAS No.: 8001-27-2
Category:  

Cardiovascular Disease Natural Products Animals Disease Research Fields Cancer

Target:  

Thrombin Apoptosis

Hirudin is a thrombin inhibitor with blood anticoagulant property. Hirudin has potent anti-thrombotic, wound repair, anti-fibrosis, anti-tumor and anti-hyperuricemia effects. Hirudin also affects diabetic complications, cerebral hemorrhage, and others .
3
Kaempferol 3-neohesperidoside
Kaempferol 3-neohesperidoside
0 Images
3 Cited Publications
Cat. No.: HY-107207
CAS No.: 32602-81-6
Purity:  99.68%
Synonyms: Kaempferol 3-O-neohesperidoside
Category:  

Flavonols Flavonoids Typhaceae Typha orientalis Presl Metabolic Disease Phenols Polyphenols Plants Disease Research Fields

Target:  

Insulin Receptor PI3K PKC

Kaempferol 3-neohesperidoside (Kaempferol 3-O-neohesperidoside) is a flavonoid. Kaempferol 3-neohesperidoside mimics insulin action via the PI3K/PKC pathway, significantly promoting glucose uptake and increasing muscle glycogen content in rat soleus muscles. Kaempferol 3-neohesperidoside also exhibits anti-glycation activity. Kaempferol 3-neohesperidoside binds to albumin through hydrogen bonding and hydrophobic interactions, and inhibits the formation of advanced glycation end products. Kaempferol 3-neohesperidoside can be used in studies of diabetes and its related complications .
2
UNC0321
UNC0321
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2 Cited Publications
Cat. No.: HY-10930
CAS No.: 1238673-32-9
Purity:  99.91%
Target:  

Histone Methyltransferase GCGR Apoptosis

Research Areas:  

Cancer

UNC0321 is a potent and selective histone methyltransferase G9a inhibitor with a Ki of 63 pM and with assay-dependent IC50 values of 6-9 nM. UNC0321 also inhibits GLP with assay-dependent IC50 values of 15-23 nM. UNC0321 has anti-apoptotic activity and has potential application in diabetic vascular complications .
2
Sorbinil
Sorbinil
0 Images
2 Cited Publications
Cat. No.: HY-50289
CAS No.: 68367-52-2
Target:  

Aldose Reductase

Research Areas:  

Metabolic Disease

Sorbinil is an aldose reductase inhibitor (ARI) that prevents the accumulation of sorbitol in cells or animals. Sorbinil is useful in studying diabetes and diabetic complications, reducing AR activity and inhibiting the polyol pathway.
2
Calphostin C
Calphostin C
0 Images
2 Cited Publications
Cat. No.: HY-105416
CAS No.: 121263-19-2
Purity:  99.00%
Synonyms: UCN-1028C
Target:  

Antibiotic PKC Apoptosis

Research Areas:  

Metabolic Disease Cancer

Calphostin C is a highly selective PKC inhibitor (IC50=0.05 μM) and tumor apoptosis inducer. Calphostin C competitively binds to PKC and inhibits PKC-mediated phosphorylation signal transduction. Calphostin C restores Na+/K+ ATPase activity in the sciatic nerve of diabetic mice and improves neuropathy. Calphostin C can be used in the study of anti-tumor and diabetic complications .
2
Exisulind
Exisulind
0 Images
2 Cited Publications
Cat. No.: HY-13633
CAS No.: 59864-04-9
Purity:  98.03%
Target:  

Aldose Reductase

Research Areas:  

Metabolic Disease Cancer

Exisulind is an inactive metabolite of the nonsteroidal, anti-inflammatory agent sulindac . Exisulind inhibits aldose reductase with an IC50 of 367 nM in vitro and may contribute to the beneficial pharmacological effects of sulindac on type 2 diabetic complications .
1
Thiamine hydrochloride
Thiamine hydrochloride
0 Images
1 Cited Publications
Cat. No.: HY-N0680
CAS No.: 67-03-8
Synonyms: Thiamine chloride hydrochloride; Vitamin B1 hydrochloride
Category:  

Human Gut Microbiota Metabolites Natural Products Endogenous metabolite

Target:  

Endogenous Metabolite Keap1-Nrf2 Toll-like Receptor (TLR) NF-κB

Thiamine hydrochloride (Thiamine chloride hydrochloride) is an essential micronutrient needed as a cofactor for many central metabolic enzymes.Thiamine hydrochloride activates NrF-2/HO-1 and inhibits TLR4, NF-κB. Thiamine hydrochloride has neuroprotective and anti-inflammatory effects. Thiamine hydrochloride can be used in the studys of diabetic complications, neurological diseases, cancers, and colitis .
1
Benfotiamine
Benfotiamine
0 Images
1 Cited Publications
Cat. No.: HY-17374
CAS No.: 22457-89-2
Synonyms: S-Benzoylthiamine O-monophosphate
Target:  

SARS-CoV HIV

Research Areas:  

Infection Metabolic Disease Inflammation/Immunology

Benfotiamine (S-Benzoylthiamine O-monophosphate) is a vitamin B1 derivative that exhihibits potent antioxidative and anti-inflammatory activity. Benfotiamine can be used for the research of various secondary diabetic complications. Benfotiamine also can be used in infectious diseases such as HIV and COVID-19 .
1
Zopolrestat
Zopolrestat
0 Images
1 Cited Publications
Cat. No.: HY-19687
CAS No.: 110703-94-1
Synonyms: CP73850
Target:  

Aldose Reductase

Research Areas:  

Metabolic Disease

Zopolrestat (CP73850) is a potent, orally active aldose reductase (AR) inhibitor with an IC50 of 3.1 nM. Zopolrestat is used for the research of diabetic complications .
1
Capillarisin
Capillarisin
0 Images
1 Cited Publications
Cat. No.: HY-121192
CAS No.: 56365-38-9
Purity:  99.27%
Category:  

Flavonoids Flavones Phenols Polyphenols Plants Compositae Artemisia capillaris Thunb.

Target:  

Reactive Oxygen Species (ROS)

Capillarisin, as a constituent from Artemisiae Capillaris herba, is found to exert anti-inflammatory and antioxidant properties. Capillarisin can be used for the research of asthma-mediated complications and can be a potential neuroprotectant against bupivacaine-induced neurotoxicity .
1
Molsidomine
Molsidomine
0 Images
1 Cited Publications
Cat. No.: HY-B1069
CAS No.: 25717-80-0
Synonyms: SIN-10; Morsydomine
Target:  

Drug Metabolite

Research Areas:  

Cardiovascular Disease Neurological Disease Metabolic Disease

Molsidomine, a nitric oxide (NO) donor, is an orally active vasodilator agent. Molsidomine is a prodrug that can be rapidly metabolized in the liver to its active metabolite, Linsidomine (HY-101200). Molsidomine can be used for the study of angina pectoris, mental disorders and diabetic complications .
1
Allyl methyl sulfide
Allyl methyl sulfide
0 Images
1 Cited Publications
Cat. No.: HY-128447
CAS No.: 10152-76-8
Purity:  ≥98.0%
Category:  

Infection Natural Products Liliaceae Plants Endogenous metabolite Disease Research Fields  A．Sativam L. var．Viviparum Regel

Target:  

Endogenous Metabolite SOD NF-κB GLUT

Allyl methyl sulfide is an orally active organic sulfide. Allyl methyl sulfide is one of the main active ingredients in garlic volatile metabolites. Allyl methyl sulfide can be extracted from garlic. Allyl methyl sulfide enhances SOD activity, inhibits NF-κB signaling pathway, and upregulates pancreatic GLUT2 expression. Allyl methyl sulfide has significant antioxidant, anti-inflammatory and hypoglycemic activities. Allyl methyl sulfide can be used in the research of diabetes and its complications .
1
Soyasaponin Ba
Soyasaponin Ba
0 Images
1 Cited Publications
Cat. No.: HY-N0309
CAS No.: 114590-20-4
Category:  

Triterpenes Leguminosae Glycine max (L.) merr Terpenoids Metabolic Disease Plants Disease Research Fields

Target:  

Aldose Reductase Akt GSK-3 β-catenin Reactive Oxygen Species (ROS) Mitochondrial Metabolism Apoptosis c-Myc

Soyasaponin Ba is a soyasaponin that can be isolated from Phaseolus vulgaris, acts as an aldose reductase inhibitor (ARI). Soyasaponin Ba activates Akt/GSK3β/β-catenin signaling pathway, reduces lipid accumulation, lowers ROS generation, improves mitochondrial membrane potential, ATP levels, and morphology, and inhibits apoptosis. Soyasaponin Ba can be used for the research of lipid accumulation and secondary diabetic complications .
Gemigliptin tartrate
Gemigliptin tartrate
0 Images
Cat. No.: HY-14892A
CAS No.: 1374639-74-3
Purity:  98.17%
Synonyms: LC15-0444 tartrate
Target:  

Dipeptidyl Peptidase

Research Areas:  

Metabolic Disease

Gemigliptin tartrate (LC15-0444 tartrate) is a highly selective, reversible and competitive dipeptidyl peptidase-4 (DPP-4) inhibitor, with an IC50 of 10.3 nM for human recombinant DPP-4. Gemigliptin tartrate exhibits potent anti-glycation properties. Gemigliptin tartrate can be used for the research of advanced glycation end products (AGE)-related diabetic complications .
Fosribnicotinamide-d4
Fosribnicotinamide-d4
0 Images
Cat. No.: HY-F0004S
Synonyms: β-Nicotinamide mononucleotide-d4; β-NM-d4; NMN-d4
Fosribnicotinamide-d4 (β-Nicotinamide mononucleotide-d4) is the deuterium labeled Fosribnicotinamide. Fosribnicotinamide is a product of the nicotinamide phosphoribosyltransferase (NAMPT) reaction and a key NAD+ intermediate. The pharmacological activities of Fosribnicotinamide include its role in cellular biochemical functions, cardioprotection, diabetes, Alzheimer's disease, and complications associated with obesity .
Upacicalcet sodium
Upacicalcet sodium
0 Images
Cat. No.: HY-109106A
CAS No.: 2052969-18-1
Purity:  99.91%
Synonyms: SK-1403; AJT240; PLS240
Target:  

CaSR

Research Areas:  

Endocrinology

Upacicalcet sodium is a non-peptide calcimimetic that acts as a CaSR agonist (EC50 = 10.8 nM). Upacicalcet sodium reduces serum intact parathyroid hormone (iPTH) and serum Ca 2+ levels, reducing hypocalcemia and gastrointestinal complications. Upacicalcet sodium sodium improves vascular calcification and bone disorders in the Adenine (HY-B0152)-induced secondary hyperparathyroidism (SHPT) rat model. Upacicalcet sodium sodium inhibits cortical pore formation and reduces bone fibrosis in rats with chronic kidney disease (CKD). Upacicalcet sodium is useful for studying SHPT .
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