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Results for "

Cytochalasin L

" in MedChemExpress (MCE) Product Catalog:

By Targets:	Antibiotic (2) Apoptosis (1) Arp2/3 Complex (8) Autophagy (1) Bacterial (1) Bcl-2 Family (1) Caspase (1) Endogenous Metabolite (2) Exosomes (1) Fungal (2) HIV Protease (1) Microtubule/Tubulin (1) Parasite (2) Reactive Oxygen Species (ROS) (1) YAP (1)
By Research Areas:	Cancer (11) Infection (8) Inflammation/Immunology (1)

Inhibitors & Agonists

Peptides

Natural
Products

Cat. No.	Product Name	Target	Research Areas	Chemical Structure

HY-16928

Cytochalasin B 40+ Cited Publications Phomin	Arp2/3 Complex	Cancer
Cytochalasin B is a cell-permeable mycotoxin binding to the barbed end of actin filaments, disrupting the formation of actin polymers, with K_d value of 1.4-2.2 nM for F-actin. Cytochalasin B blocks cell migration.

HY-N6682

Cytochalasin D Maximum Cited Publications 91 Publications Verification Zygosporin A; NSC 209835	Exosomes Arp2/3 Complex Antibiotic YAP	Infection Cancer
Cytochalasin D (Zygosporin A) is a potent actin polymerization inhibitor, could be derived from fungus. Cytochalasin D has cell-permeable activity. Cytochalasin D inhibits the G-actin–cofilin interaction by binding to G-actin. Cytochalasin D also inhibits the binding of cofilin to F-actin and decreases the rate of both actin polymerization and depolymerization in living cells. Cytochalasin D can reduce exosome release, in turn reducing the amount of survivin present in the tumour environment. Cytochalasin D induces phosphorylation and cytoplasmic retention of Yap .

HY-P2031

Phallacidin	Arp2/3 Complex	Others
Phallacidin is a natural bicyclic heptapeptide derived from the poisonous mushroom Amanita phalloides. Phallacidin binds to filamentous actin specifically with high affinity, with a K_d of 20 nM. After binding to F-actin, Phallacidin strongly inhibits its depolymerization, stabilizes microfilament structures, and prevents their disruption by drugs such as cytochalasins. When conjugated with a fluorophore, Phallacidin serves as a specific fluorescent probe for F-actin, which is used to clearly visualize the distribution of actin in the cytoskeleton (e.g., stress fibers, cortical peripheral bands) under fluorescence microscopy .

HY-N6773

Cytochalasin A	HIV Protease Fungal	Infection
Cytochalasin A is a cell-permeable fungal toxin that is an oxidized derivative of cytochalasin B. Cytochalasin A is an inhibitor of HIV-1 protease (IC₅₀=3 μM) and inhibits actin polymerization and interferes with microtubule assembly by reacting with sulfhydryl groups. Antibiotic and fungicidal activitives .

HY-N6774

Cytochalasin C 1 Publications Verification	Others	Infection
Cytochalasin C is a cell-permeable fungal toxin and induces the formation of nuclear rodlets. Cytochalasin C is 10 times less toxic in mice than is cytochalasin D .

HY-N6772

Cytochalasin E	Autophagy	Cancer
Cytochalasin E, an epoxide containing Aspergillus-derived fungal metabolite, inhibits angiogenesis and tumor growth. Cytochalasin E is a potent actin depolymerization agent, and it binds and caps the barbed end of actin filaments to prevent actin elongation .

HY-N8349

19,20-Epoxycytochalasin D	Parasite Endogenous Metabolite	Infection Cancer
19,20-Epoxycytochalasin D, a cytochalasin, is a fungal metabolite from Nemania sp. 19,20-Epoxycytochalasin D shows potent in vitro antiplasmodial activity and phytotoxicity .

HY-129325

Cytochalasin H	Antibiotic Bacterial Apoptosis Bcl-2 Family Caspase	Infection Cancer
Cytochalasin H is a nature product that could be isolated from fungus Phomopsis sp. Cytochalasin H inhibits cell growth and induces apoptosis. Cytochalasin H has anti-angiogenic activity. Cytochalasin H is an antibiotic and has antibacterial activity .

HY-N14569

Cytochalasin L	Arp2/3 Complex	Cancer
Cytochalasin L has many biological activities, such as inhibiting cytoKinesis reversibly, inhibiting megasophil endocytosis and exocytosis .

HY-N10291

10-Phenyl-[12]-cytochalasins Z16	Others	Others
10-Phenyl-[12]-cytochalasins Z16 (Compounds 5) is a cytochalasin that inhibits wheat root elongation with an IC₅₀ of 17.35 μM .

HY-N12195

Cytochalasin R	Fungal	Infection
Cytochalasin R (compound 17) is a cytochalasin analogue that can be isolated from the endophytic fungus Phomopsis sp. xz-18. Cytochalasin R shows potential antifungal activity .

HY-126556

Cytochalasin J	Microtubule/Tubulin	Cancer
Cytochalasin J is a cytochalasin detivative. Cytochalasin J affects mitotic spindel microtubule organization and kinetochore structure, and exhibits cytotoxicity in human leukemia K562 cell with IC₅₀ of 1.5 μM .

HY-N10290

Cytochalasin K	Others	Others
Cytochalasin K (Compounds 7) is a cytochalasin that inhibits wheat root elongation with an IC₅₀ of 22.58 μM .

HY-N14567

Cytochalasin F	Arp2/3 Complex	Cancer
Cytochalasin F has many biological activities, such as inhibiting cytoKinesis reversibly, inhibiting megasophil endocytosis and exocytosis .

HY-N14568

Cytochalasin G	Arp2/3 Complex	Cancer
Cytochalasin G has many biological activities, such as inhibiting cytoKinesis reversibly, inhibiting megasophil endocytosis and exocytosis .

HY-N14696

Cytochalasin M	Arp2/3 Complex	Cancer
Cytochalasin M has many biological activities, such as inhibiting cytoKinesis reversibly, inhibiting megasophil endocytosis and exocytosis .

HY-N8385

19,20-Epoxycytochalasin C	Parasite Endogenous Metabolite	Infection Cancer
19,20-Epoxycytochalasin C, a cytochalasin, is a fungal metabolite from Nemania sp. 19,20-Epoxycytochalasin C shows potent in vitro antiplasmodial activity and phytotoxicity .

HY-W699318

1-Oleoyl-2-palmitoylglycerol	Reactive Oxygen Species (ROS)	Others
1-Oleoyl-2-palmitoylglycerol is a diacylglycerol in which an oleic acid and a palmitic acid are attached to sn-1 and sn-2 position. 1-Oleoyl-2-palmitoylglycerol enhances the inhibition of superoxide anion production induced by fMLF/cytochalasin B (CB) in human neutrophils. 1-Oleoyl-2-palmitoylglycerol can be used in research about lipid metabolism, membrane fluidity, or the distribution and function of lipids in cells .

HY-182491

Cytochalasin Z2	Others	Others
Cytochalasin Z2 is a 24-oxa-[14]cytochalasan. Cytochalasin Z2 is isolated from wheat cultures of Pyrenophora semeniperda. Cytochalasin Z2 shows no activity in root elongation assays of wheat and tomato seedlings .

HY-N12193

Cytochalasin N	Others	Others
Cytochalasin N is a cytorelaxin derived from endophytic fungus Phomopsis sp.CIB-109 .

HY-N12194

Cytochalasin O	Others	Infection
Cytochalasin O (compound 13) is a secondary metabolite of the phytopathogenic fungus P. sp. CIB-109 .

HY-182487

Deoxaphomin	Arp2/3 Complex	Inflammation/Immunology
Deoxaphomin is a cytochalasin. Deoxaphomin inhibits Actin filament elongation and reduces the viscosity of polymerized actin filaments. Deoxaphomin induces rounding of fibroblasts, contraction of actin cables, formation of actin-containing hairy structures, and formation of actin-containing cytoplasmic rodlets in fibroblasts. Deoxaphomin inhibits membrane ruffling in fibroblasts and capping in lymphocytes .

Cat. No.	Product Name	Target	Research Area

HY-P2031

Phallacidin	Arp2/3 Complex	Others
Phallacidin is a natural bicyclic heptapeptide derived from the poisonous mushroom Amanita phalloides. Phallacidin binds to filamentous actin specifically with high affinity, with a K_d of 20 nM. After binding to F-actin, Phallacidin strongly inhibits its depolymerization, stabilizes microfilament structures, and prevents their disruption by drugs such as cytochalasins. When conjugated with a fluorophore, Phallacidin serves as a specific fluorescent probe for F-actin, which is used to clearly visualize the distribution of actin in the cytoskeleton (e.g., stress fibers, cortical peripheral bands) under fluorescence microscopy .

Cytochalasin B 40+ Cited Publications Phomin	Natural Products Microorganisms Classification of Application Fields Disease Research Fields Source Classification Cancer	Arp2/3 Complex
Cytochalasin B is a cell-permeable mycotoxin binding to the barbed end of actin filaments, disrupting the formation of actin polymers, with K_d value of 1.4-2.2 nM for F-actin. Cytochalasin B blocks cell migration.

Cytochalasin D Maximum Cited Publications 91 Publications Verification Zygosporin A; NSC 209835	Infection Structural Classification Natural Products Microorganisms Classification of Application Fields Disease Research Fields Source Classification	Exosomes Arp2/3 Complex Antibiotic YAP
Cytochalasin D (Zygosporin A) is a potent actin polymerization inhibitor, could be derived from fungus. Cytochalasin D has cell-permeable activity. Cytochalasin D inhibits the G-actin–cofilin interaction by binding to G-actin. Cytochalasin D also inhibits the binding of cofilin to F-actin and decreases the rate of both actin polymerization and depolymerization in living cells. Cytochalasin D can reduce exosome release, in turn reducing the amount of survivin present in the tumour environment. Cytochalasin D induces phosphorylation and cytoplasmic retention of Yap .

Phallacidin	Structural Classification Microorganisms Classification of Application Fields Ketones, Aldehydes, Acids Other Diseases Disease Research Fields Source Classification	Arp2/3 Complex
Phallacidin is a natural bicyclic heptapeptide derived from the poisonous mushroom Amanita phalloides. Phallacidin binds to filamentous actin specifically with high affinity, with a K_d of 20 nM. After binding to F-actin, Phallacidin strongly inhibits its depolymerization, stabilizes microfilament structures, and prevents their disruption by drugs such as cytochalasins. When conjugated with a fluorophore, Phallacidin serves as a specific fluorescent probe for F-actin, which is used to clearly visualize the distribution of actin in the cytoskeleton (e.g., stress fibers, cortical peripheral bands) under fluorescence microscopy .

Cytochalasin A	Infection Alkaloids Microorganisms Pyrrole Alkaloids Classification of Application Fields Disease Research Fields Source Classification	HIV Protease Fungal
Cytochalasin A is a cell-permeable fungal toxin that is an oxidized derivative of cytochalasin B. Cytochalasin A is an inhibitor of HIV-1 protease (IC₅₀=3 μM) and inhibits actin polymerization and interferes with microtubule assembly by reacting with sulfhydryl groups. Antibiotic and fungicidal activitives .

Cytochalasin C 1 Publications Verification	Infection Alkaloids Microorganisms Pyrrole Alkaloids Classification of Application Fields Disease Research Fields Source Classification	Others
Cytochalasin C is a cell-permeable fungal toxin and induces the formation of nuclear rodlets. Cytochalasin C is 10 times less toxic in mice than is cytochalasin D .

Cytochalasin E	Alkaloids Microorganisms Pyrrole Alkaloids Classification of Application Fields Disease Research Fields Source Classification Cancer	Autophagy
Cytochalasin E, an epoxide containing Aspergillus-derived fungal metabolite, inhibits angiogenesis and tumor growth. Cytochalasin E is a potent actin depolymerization agent, and it binds and caps the barbed end of actin filaments to prevent actin elongation .

19,20-Epoxycytochalasin D	Infection Microorganisms Classification of Application Fields Ketones, Aldehydes, Acids Disease Research Fields Source Classification	Parasite Endogenous Metabolite
19,20-Epoxycytochalasin D, a cytochalasin, is a fungal metabolite from Nemania sp. 19,20-Epoxycytochalasin D shows potent in vitro antiplasmodial activity and phytotoxicity .

Cytochalasin H	Antibiotics Gramineae Plants Paspalum scrobiculatum L. Source Classification	Antibiotic Bacterial Apoptosis Bcl-2 Family Caspase
Cytochalasin H is a nature product that could be isolated from fungus Phomopsis sp. Cytochalasin H inhibits cell growth and induces apoptosis. Cytochalasin H has anti-angiogenic activity. Cytochalasin H is an antibiotic and has antibacterial activity .

Cytochalasin L	Natural Products Microorganisms Source Classification	Arp2/3 Complex
Cytochalasin L has many biological activities, such as inhibiting cytoKinesis reversibly, inhibiting megasophil endocytosis and exocytosis .

10-Phenyl-[12]-cytochalasins Z16	Alkaloids Human Gut Microbiota Metabolites Microorganisms Classification of Application Fields Other Diseases Endogenous metabolite Disease Research Fields Source Classification	Others
10-Phenyl-[12]-cytochalasins Z16 (Compounds 5) is a cytochalasin that inhibits wheat root elongation with an IC₅₀ of 17.35 μM .

Cytochalasin R	Structural Classification Alkaloids Microorganisms Pyrrole Alkaloids Source Classification	Fungal
Cytochalasin R (compound 17) is a cytochalasin analogue that can be isolated from the endophytic fungus Phomopsis sp. xz-18. Cytochalasin R shows potential antifungal activity .

Cytochalasin J	Natural Products Microorganisms Source Classification	Microtubule/Tubulin
Cytochalasin J is a cytochalasin detivative. Cytochalasin J affects mitotic spindel microtubule organization and kinetochore structure, and exhibits cytotoxicity in human leukemia K562 cell with IC₅₀ of 1.5 μM .

Cytochalasin K	Alkaloids Human Gut Microbiota Metabolites Microorganisms Classification of Application Fields Other Diseases Endogenous metabolite Disease Research Fields Source Classification	Others
Cytochalasin K (Compounds 7) is a cytochalasin that inhibits wheat root elongation with an IC₅₀ of 22.58 μM .

Cytochalasin F	Natural Products Microorganisms Source Classification	Arp2/3 Complex
Cytochalasin F has many biological activities, such as inhibiting cytoKinesis reversibly, inhibiting megasophil endocytosis and exocytosis .

Cytochalasin G	Natural Products Microorganisms Source Classification	Arp2/3 Complex
Cytochalasin G has many biological activities, such as inhibiting cytoKinesis reversibly, inhibiting megasophil endocytosis and exocytosis .

Cytochalasin M	Natural Products Microorganisms Source Classification	Arp2/3 Complex
Cytochalasin M has many biological activities, such as inhibiting cytoKinesis reversibly, inhibiting megasophil endocytosis and exocytosis .

19,20-Epoxycytochalasin C	Infection Microorganisms Classification of Application Fields Ketones, Aldehydes, Acids Disease Research Fields Source Classification	Parasite Endogenous Metabolite
19,20-Epoxycytochalasin C, a cytochalasin, is a fungal metabolite from Nemania sp. 19,20-Epoxycytochalasin C shows potent in vitro antiplasmodial activity and phytotoxicity .

Cytochalasin Z2	Structural Classification Alkaloids Microorganisms Indole Alkaloids Source Classification	Others
Cytochalasin Z2 is a 24-oxa-[14]cytochalasan. Cytochalasin Z2 is isolated from wheat cultures of Pyrenophora semeniperda. Cytochalasin Z2 shows no activity in root elongation assays of wheat and tomato seedlings .

Cytochalasin N	Natural Products Microorganisms Source Classification	Others
Cytochalasin N is a cytorelaxin derived from endophytic fungus Phomopsis sp.CIB-109 .

Cytochalasin O	Natural Products Microorganisms Source Classification	Others
Cytochalasin O (compound 13) is a secondary metabolite of the phytopathogenic fungus P. sp. CIB-109 .

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Cytochalasin L

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