1-Oleoyl-2-palmitoylglycerol
1-Oleoyl-2-palmitoylglycerol is a diacylglycerol in which an oleic acid and a palmitic acid are attached to sn-1 and sn-2 position. 1-Oleoyl-2-palmitoylglycerol enhances the inhibition of superoxide anion production induced by fMLF/cytochalasin B (CB) in human neutrophils. 1-Oleoyl-2-palmitoylglycerol can be used in research about lipid metabolism, membrane fluidity, or the distribution and function of lipids in cells.
For research use only. We do not sell to patients.
- CAS No.: 3331-34-8
- Formula: C37H70O5
- Molecular Weight:594.95
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Storage:
Please store the product under the recommended conditions in the Certificate of Analysis.
To place orders, for customer services and technical support, please contact: MedChemExpress USA
Tel: 609-228-6898 E-mail: [email protected] [email protected]
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Biological Activity
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Chemical Information
- Purity & Documentation
- References
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Help & FAQs
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Biological Activity
Description
Cellular Effect
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Cell Line
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Type | Value | Description | References |
|---|---|---|---|---|
| A549 | IC50 |
>10 μM
Compound: 8
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Cytotoxicity against human A549 cells assessed as reduction in cell viability after 72 hrs by MTT assay
Cytotoxicity against human A549 cells assessed as reduction in cell viability after 72 hrs by MTT assay
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[PMID: 28445049] |
| HepG2 | IC50 |
>10 μM
Compound: 8
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Cytotoxicity against human HepG2 cells assessed as reduction in cell viability after 72 hrs by MTT assay
Cytotoxicity against human HepG2 cells assessed as reduction in cell viability after 72 hrs by MTT assay
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[PMID: 28445049] |
| MDA-MB-231 | IC50 |
>10 μM
Compound: 8
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Cytotoxicity against human MDA-MB-231 cells assessed as reduction in cell viability after 72 hrs by MTT assay
Cytotoxicity against human MDA-MB-231 cells assessed as reduction in cell viability after 72 hrs by MTT assay
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[PMID: 28445049] |
| Neutrophil | IC50 |
>10 μM
Compound: 8
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Anti-inflammatory activity in human neutrophils assessed as inhibition of fMLF/CB-induced elastase release by measuring degranulation of azurophilic granules using MeOSuc-Ala-Ala-ProVal-p-nitroanilide as substrate preincubated for 5 mins followed by CB/fM
Anti-inflammatory activity in human neutrophils assessed as inhibition of fMLF/CB-induced elastase release by measuring degranulation of azurophilic granules using MeOSuc-Ala-Ala-ProVal-p-nitroanilide as substrate preincubated for 5 mins followed by CB/fM
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[PMID: 28445049] |
Chemical Information
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CAS No. 3331-34-8
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Molecular Weight 594.95
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Formula C37H70O5
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SMILES
CCCCCCCCCCCCCCCC(OC(CO)COC(CCCCCCC/C=C\CCCCCCCC)=O)=O
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Shipping
Room temperature in continental US; may vary elsewhere.
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Storage
Please store the product under the recommended conditions in the Certificate of Analysis.
Purity & Documentation
References
[1]. Dickens BF, et al., Quantification of phospholipid molecular species by coupled gas chromatography-mass spectrometry of deuterated samples. Anal Biochem. 1982 Nov 15;127(1):37-48. [Content Brief]
[2]. Wagh VD, et al., Inflammation Modulatory Phorbol Esters from the Seeds of Aquilaria malaccensis. J Nat Prod. 2017 May 26;80(5):1421-1427. [Content Brief]
Calculators
Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
1-Oleoyl-2-palmitoylglycerol Related Classifications
HY-W699318 Related Classifications
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